Mark2 MAP/microtubule affinity regulating kinase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mark2provided by MGI
Official Full Name: MAP/microtubule affinity regulating kinase 2provided by MGI
Primary source: MGI:MGI:99638
See related: Ensembl:ENSMUSG00000024969 AllianceGenome:MGI:99638
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Emk; EMK-1; Par-1; Par-1b
Summary: Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and protein kinase activity. Predicted to be involved in several processes, including generation of neurons; protein phosphorylation; and regulation of neuron projection development. Located in basal cortex and nucleus. Is active in glutamatergic synapse and postsynapse. Is expressed in brain; early conceptus; and oocyte. Orthologous to human MARK2 (microtubule affinity regulating kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in duodenum adult (RPKM 24.0), colon adult (RPKM 22.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 5.32 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (7252761..7319222, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (7275396..7341860, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MARK2 phosphorylates KIF13A at a 14-3-3 binding site to polarize vesicular transport of transferrin receptor within dendrites.
Title: MARK2 phosphorylates KIF13A at a 14-3-3 binding site to polarize vesicular transport of transferrin receptor within dendrites.
LKB1-MARK2 signalling mediates lipopolysaccharide-induced production of cytokines in mouse macrophages.
Title: LKB1-MARK2 signalling mediates lipopolysaccharide-induced production of cytokines in mouse macrophages.
This studies show that loss of Par1b/MARK2 switches microglia from a surveillant to a primed state during development, resulting in an increased neuroinflammatory response to insults
Title: Loss of Par1b/MARK2 primes microglia during brain development and enhances their sensitivity to injury.
These results indicate that the basal localization of Par-1b in the outer epithelial cells is required for myoepithelial cell compression, and Par-1b is required for myoepithelial differentiation, regardless of its localization.
Title: Par-1b is required for morphogenesis and differentiation of myoepithelial cells during salivary gland development.
data suggest ectopic PAR1 expression is not tolerated in mouse platelets and indicate a different approach is required to develop a small animal model for the purpose of any future preclinical testing of PAR antagonists as anti-platelet drugs
Title: Humanizing the Protease-Activated Receptor (PAR) Expression Profile in Mouse Platelets by Knocking PAR1 into the Par3 Locus Reveals PAR1 Expression Is Not Tolerated in Mouse Platelets.
a model whereby MARK2 negatively regulates insulin sensitivity in peripheral tissue through inhibition of KSR1
Title: Regulation of glucose homeostasis by KSR1 and MARK2.
ROCK1/PAR-1b-dependent regulation of basement membrane placement is required for the coordination of tissue polarity and the elaboration of tissue structure in the developing submandibular salivary gland.
Title: ROCK1-directed basement membrane positioning coordinates epithelial tissue polarity.
PAR1b plays a novel role in the maintenance of mature dendritic spine morphology by regulating microtubule growth and the accumulation of p140Cap in dendritic spines.
Title: Maintenance of dendritic spine morphology by partitioning-defective 1b through regulation of microtubule growth.
Coreduction of MARK2 and DCX resulted in a partial restoration of the normal neuronal migration phenotype in vivo. The kinetic behavior of the centrosomes reflected the different molecular mechanisms activated when either protein was reduced.
Title: Antagonistic effects of doublecortin and MARK2/Par-1 in the developing cerebral cortex.
Akt enhances the activity of PAR1 to promote tau hyperphosphorylation at S262/S356, a tau species that is not recognized by the CHIP/Hsp90 complex
Title: Akt and CHIP coregulate tau degradation through coordinated interactions.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW122124 (e-PCR)
- UniSTS:186143

AU024026 (e-PCR)
- UniSTS:181185

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables molecular function activator activity	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
enables tau protein binding	ISO Inferred from Sequence Orthology more info
enables tau-protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tau-protein kinase activity	ISO Inferred from Sequence Orthology more info
enables tau-protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in axon development	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in establishment of cell polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment of cell polarity	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment or maintenance of cell polarity regulating cell shape	ISO Inferred from Sequence Orthology more info
involved_in establishment or maintenance of epithelial cell apical/basal polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment or maintenance of epithelial cell apical/basal polarity	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron migration	ISO Inferred from Sequence Orthology more info
involved_in neuron migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of axonogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynapse organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actin filament	ISO Inferred from Sequence Orthology more info
located_in actin filament	ISS Inferred from Sequence or Structural Similarity more info
located_in basal cortex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule bundle	ISO Inferred from Sequence Orthology more info
located_in microtubule bundle	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein kinase MARK2

Names: ELKL motif kinase 1; PAR1 homolog b

NP_001073857.1

EC 2.7.11.1

EC 2.7.11.26

NP_001073858.1

EC 2.7.11.1

EC 2.7.11.26

NP_001073859.1

EC 2.7.11.1

EC 2.7.11.26

NP_001397177.1

EC 2.7.11.1

EC 2.7.11.26

NP_001397178.1

EC 2.7.11.1

EC 2.7.11.26

NP_001397179.1

EC 2.7.11.1

EC 2.7.11.26

NP_031954.2

EC 2.7.11.1

EC 2.7.11.26

XP_006526704.1

EC 2.7.11.1

EC 2.7.11.26

XP_006526705.1

EC 2.7.11.1

EC 2.7.11.26

XP_006526706.1

EC 2.7.11.1

EC 2.7.11.26

XP_006526707.1

EC 2.7.11.1

EC 2.7.11.26

XP_006526708.1

EC 2.7.11.1

EC 2.7.11.26

XP_006526709.1

EC 2.7.11.1

EC 2.7.11.26

XP_006526710.1

EC 2.7.11.1

EC 2.7.11.26

XP_006526711.1

EC 2.7.11.1

EC 2.7.11.26

XP_006526713.1

EC 2.7.11.1

EC 2.7.11.26

XP_006526715.1

EC 2.7.11.1

EC 2.7.11.26

XP_006526717.1

EC 2.7.11.1

EC 2.7.11.26

XP_006526719.1

EC 2.7.11.1

EC 2.7.11.26

XP_017173548.1

EC 2.7.11.1

EC 2.7.11.26

XP_030106603.1

EC 2.7.11.1

EC 2.7.11.26

XP_030106604.1

EC 2.7.11.1

EC 2.7.11.26

XP_036017316.1

EC 2.7.11.1

EC 2.7.11.26

XP_036017318.1

EC 2.7.11.1

EC 2.7.11.26

XP_036017319.1

EC 2.7.11.1

EC 2.7.11.26

XP_036017320.1

EC 2.7.11.1

EC 2.7.11.26

XP_036017321.1

EC 2.7.11.1

EC 2.7.11.26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080388.3 → NP_001073857.1 serine/threonine-protein kinase MARK2 isoform 2

See identical proteins and their annotated locations for NP_001073857.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

AC129188, AC140307

Consensus CDS

CCDS50378.1

UniProtKB/TrEMBL

A0A0R4J227, E9Q9N6

Related

ENSMUSP00000127827.2, ENSMUST00000164205.8

Conserved Domains (4) summary

cd12201
Location:623 → 721

MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2

smart00220
Location:53 → 304

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14406
Location:322 → 363

UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins

cd14072
Location:52 → 304

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
NM_001080389.3 → NP_001073858.1 serine/threonine-protein kinase MARK2 isoform 3

See identical proteins and their annotated locations for NP_001073858.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks one exon and contains an alternate exon in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.

Source sequence(s)

AC129188, AC140307

Consensus CDS

CCDS37903.1

UniProtKB/TrEMBL

A0A0R4J0B1, E9Q9N6

Related

ENSMUSP00000032557.9, ENSMUST00000032557.15

Conserved Domains (4) summary

cd12201
Location:632 → 730

MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2

smart00220
Location:53 → 304

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14406
Location:322 → 363

UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins

cd14072
Location:52 → 304

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
NM_001080390.3 → NP_001073859.1 serine/threonine-protein kinase MARK2 isoform 4

See identical proteins and their annotated locations for NP_001073859.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks part of the 5' coding region, uses an alternate 5'-terminal exon, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC140307

Consensus CDS

CCDS37905.1

UniProtKB/TrEMBL

Q3T9A3, Q3U3A1

Related

ENSMUSP00000025921.9, ENSMUST00000025921.15

Conserved Domains (3) summary

cd12201
Location:644 → 742

MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2

cd14406
Location:289 → 330

UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins

cd14072
Location:19 → 271

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
NM_001410248.1 → NP_001397177.1 serine/threonine-protein kinase MARK2 isoform 5

Status: VALIDATED

Source sequence(s)

AC129188, AC140307

UniProtKB/TrEMBL

E9Q9N6
NM_001410249.1 → NP_001397178.1 serine/threonine-protein kinase MARK2 isoform 6

Status: VALIDATED

Source sequence(s)

AC129188, AC140307

UniProtKB/Swiss-Prot

Q05512, Q3T9L3, Q6PDR4, Q8BR95

Related

ENSMUSP00000129506.2, ENSMUST00000171721.8
NM_001410250.1 → NP_001397179.1 serine/threonine-protein kinase MARK2 isoform 7

Status: VALIDATED

Source sequence(s)

AC129188, AC140307

UniProtKB/TrEMBL

E9Q9N6
NM_007928.4 → NP_031954.2 serine/threonine-protein kinase MARK2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC129188, AC140307

Consensus CDS

CCDS37904.1

UniProtKB/Swiss-Prot

Q05512, Q3T9L3, Q6PDR4, Q8BR95

UniProtKB/TrEMBL

E9PWB5, E9QMP6

Related

ENSMUSP00000131684.2, ENSMUST00000165965.8

Conserved Domains (4) summary

cd12201
Location:677 → 775

MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2

smart00220
Location:53 → 304

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14406
Location:322 → 363

UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins

cd14072
Location:52 → 304

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

7252761..7319222 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526645.3 → XP_006526708.1 serine/threonine-protein kinase MARK2 isoform X4

See identical proteins and their annotated locations for XP_006526708.1

UniProtKB/TrEMBL

Q3U3A1

Conserved Domains (3) summary

cd12201
Location:709 → 807

MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2

cd14406
Location:289 → 330

UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins

cd14072
Location:19 → 271

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_036161427.1 → XP_036017320.1 serine/threonine-protein kinase MARK2 isoform X19

UniProtKB/TrEMBL

E9Q9N6

Conserved Domains (3) summary

cd12201
Location:590 → 688

MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2

cd14406
Location:289 → 330

UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins

cd14072
Location:19 → 271

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_006526643.3 → XP_006526706.1 serine/threonine-protein kinase MARK2 isoform X3

UniProtKB/Swiss-Prot

Q05512, Q3T9L3, Q6PDR4, Q8BR95

Conserved Domains (3) summary

cd12201
Location:742 → 840

MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2

cd14406
Location:322 → 363

UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins

cd14072
Location:52 → 304

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_036161428.1 → XP_036017321.1 serine/threonine-protein kinase MARK2 isoform X19

UniProtKB/TrEMBL

E9Q9N6

Conserved Domains (3) summary

cd12201
Location:590 → 688

MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2

cd14406
Location:289 → 330

UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins

cd14072
Location:19 → 271

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_036161423.1 → XP_036017316.1 serine/threonine-protein kinase MARK2 isoform X7

UniProtKB/TrEMBL

E9Q9N6

Conserved Domains (3) summary

cd12201
Location:689 → 787

MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2

cd14406
Location:332 → 373

UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins

cd14072
Location:62 → 314

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_006526647.3 → XP_006526710.1 serine/threonine-protein kinase MARK2 isoform X5

UniProtKB/TrEMBL

E9Q9N6

Conserved Domains (3) summary

cd12201
Location:698 → 796

MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2

cd14406
Location:332 → 373

UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins

cd14072
Location:62 → 314

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_006526641.4 → XP_006526704.1 serine/threonine-protein kinase MARK2 isoform X1

UniProtKB/TrEMBL

F6ZS70

Conserved Domains (3) summary

cd12201
Location:752 → 850

MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2

cd14406
Location:332 → 373

UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins

cd14072
Location:62 → 314

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_006526652.4 → XP_006526715.1 serine/threonine-protein kinase MARK2 isoform X14

UniProtKB/TrEMBL

E9Q9N6

Conserved Domains (3) summary

cd12201
Location:642 → 740

MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2

cd14406
Location:332 → 373

UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins

cd14072
Location:62 → 314

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_006526650.4 → XP_006526713.1 serine/threonine-protein kinase MARK2 isoform X10

UniProtKB/TrEMBL

F6ZS70

Conserved Domains (3) summary

cd12201
Location:681 → 779

MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2

cd14406
Location:332 → 373

UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins

cd14072
Location:62 → 314

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_006526648.4 → XP_006526711.1 serine/threonine-protein kinase MARK2 isoform X6

UniProtKB/TrEMBL

F6ZS70

Conserved Domains (3) summary

cd12201
Location:696 → 794

MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2

cd14406
Location:332 → 373

UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins

cd14072
Location:62 → 314

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_006526644.5 → XP_006526707.1 serine/threonine-protein kinase MARK2 isoform X4

See identical proteins and their annotated locations for XP_006526707.1

UniProtKB/TrEMBL

Q3U3A1

Conserved Domains (3) summary

cd12201
Location:709 → 807

MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2

cd14406
Location:289 → 330

UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins

cd14072
Location:19 → 271

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_006526646.5 → XP_006526709.1 serine/threonine-protein kinase MARK2 isoform X4

See identical proteins and their annotated locations for XP_006526709.1

UniProtKB/TrEMBL

Q3U3A1

Conserved Domains (3) summary

cd12201
Location:709 → 807

MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2

cd14406
Location:289 → 330

UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins

cd14072
Location:19 → 271

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_017318059.3 → XP_017173548.1 serine/threonine-protein kinase MARK2 isoform X19

UniProtKB/TrEMBL

E9Q9N6

Conserved Domains (3) summary

cd12201
Location:590 → 688

MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2

cd14406
Location:289 → 330

UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins

cd14072
Location:19 → 271

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_036161425.1 → XP_036017318.1 serine/threonine-protein kinase MARK2 isoform X13

UniProtKB/TrEMBL

Q3T9A3, Q3U3A1

Conserved Domains (3) summary

cd12201
Location:644 → 742

MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2

cd14406
Location:289 → 330

UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins

cd14072
Location:19 → 271

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_036161426.1 → XP_036017319.1 serine/threonine-protein kinase MARK2 isoform X16

UniProtKB/TrEMBL

E9Q9N6

Conserved Domains (3) summary

cd12201
Location:575 → 673

MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2

cd14406
Location:289 → 330

UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins

cd14072
Location:19 → 271

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_006526642.5 → XP_006526705.1 serine/threonine-protein kinase MARK2 isoform X2

UniProtKB/TrEMBL

F6ZS70

Conserved Domains (3) summary

cd12201
Location:743 → 841

MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2

cd14406
Location:332 → 373

UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins

cd14072
Location:62 → 314

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_030250743.2 → XP_030106603.1 serine/threonine-protein kinase MARK2 isoform X12

UniProtKB/Swiss-Prot

Q05512, Q3T9L3, Q6PDR4, Q8BR95

Conserved Domains (3) summary

cd12201
Location:662 → 760

MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2

cd14406
Location:322 → 363

UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins

cd14072
Location:52 → 304

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_030250744.2 → XP_030106604.1 serine/threonine-protein kinase MARK2 isoform X17

UniProtKB/TrEMBL

E9PYX3, E9Q9N6

Related

ENSMUSP00000126468.2, ENSMUST00000165286.8

Conserved Domains (3) summary

cd12201
Location:617 → 715

MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2

cd14406
Location:322 → 363

UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins

cd14072
Location:52 → 304

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_006526654.5 → XP_006526717.1 serine/threonine-protein kinase MARK2 isoform X15

UniProtKB/TrEMBL

E9Q9N6

Conserved Domains (3) summary

cd12201
Location:627 → 725

MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2

cd14406
Location:332 → 373

UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins

cd14072
Location:62 → 314

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_006526656.4 → XP_006526719.1 serine/threonine-protein kinase MARK2 isoform X18

UniProtKB/TrEMBL

F6ZS70

Conserved Domains (2) summary

cd14406
Location:332 → 373

UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins

cd14072
Location:62 → 314

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases