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    Bcl2l12 BCL2 like 12 [ Mus musculus (house mouse) ]

    Gene ID: 75736, updated on 9-Dec-2024

    Summary

    Official Symbol
    Bcl2l12provided by MGI
    Official Full Name
    BCL2 like 12provided by MGI
    Primary source
    MGI:MGI:1922986
    See related
    Ensembl:ENSMUSG00000003190 AllianceGenome:MGI:1922986
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bcl-L12; Bcl2-L12; 2810475P17Rik; 5430429M05Rik
    Summary
    Enables p53 binding activity. Acts upstream of or within negative regulation of cellular senescence and negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Predicted to be located in nucleus. Is expressed in several structures, including adrenal gland; genitourinary system; gut; quadriceps femoris muscle; and respiratory system. Orthologous to human BCL2L12 (BCL2 like 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 30.0), limb E14.5 (RPKM 23.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Bcl2l12 in Genome Data Viewer
    Location:
    7 B3; 7 29.07 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44640646..44647011, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44991222..44997638, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene carnitine palmitoyltransferase 1c Neighboring gene STARR-seq mESC enhancer starr_18822 Neighboring gene protein arginine N-methyltransferase 1 Neighboring gene predicted gene 15545 Neighboring gene interferon regulatory factor 3 Neighboring gene SR-related CTD-associated factor 1 Neighboring gene microRNA 7054

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General protein information

    Preferred Names
    bcl-2-like protein 12
    Names
    BCL2-like 12 (proline rich)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403495.1NP_001390424.1  bcl-2-like protein 12 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC155806
    2. NM_001403496.1NP_001390425.1  bcl-2-like protein 12 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC155806
    3. NM_001403497.1NP_001390426.1  bcl-2-like protein 12 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC155806
      UniProtKB/TrEMBL
      Q9D3J3
    4. NM_029410.4NP_083686.1  bcl-2-like protein 12 isoform b

      See identical proteins and their annotated locations for NP_083686.1

      Status: VALIDATED

      Source sequence(s)
      AC155806
      Consensus CDS
      CCDS21223.1
      UniProtKB/TrEMBL
      Q9D3J3
      Related
      ENSMUSP00000003290.5, ENSMUST00000003290.12

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      44640646..44647011 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006541267.5XP_006541330.1  bcl-2-like protein 12 isoform X3

      UniProtKB/TrEMBL
      A0A140LIT0
      Conserved Domains (1) summary
      PHA03132
      Location:4158
      PHA03132; thymidine kinase; Provisional
    2. XM_036153537.1XP_036009430.1  bcl-2-like protein 12 isoform X2

      UniProtKB/TrEMBL
      A0A140LIT0
      Related
      ENSMUSP00000146945.2, ENSMUST00000207443.2
      Conserved Domains (1) summary
      PHA03132
      Location:4167
      PHA03132; thymidine kinase; Provisional

    RNA

    1. XR_003946575.2 RNA Sequence

      Related
      ENSMUST00000208128.2