Cnga4 cyclic nucleotide gated channel alpha 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cnga4provided by MGI
Official Full Name: cyclic nucleotide gated channel alpha 4provided by MGI
Primary source: MGI:MGI:2664099
See related: Ensembl:ENSMUSG00000030897 AllianceGenome:MGI:2664099
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: OCNC2
Summary: Predicted to enable cGMP binding activity; intracellularly cAMP-activated cation channel activity; and intracellularly cGMP-activated cation channel activity. Acts upstream of or within sensory perception of smell. Located in non-motile cilium membrane. Orthologous to human CNGA4 (cyclic nucleotide gated channel subunit alpha 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in testis adult (RPKM 2.1), cortex adult (RPKM 0.4) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E3; 7 55.85 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (105049247..105057981)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (105400024..105408775)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cAMP binding	IEA Inferred from Electronic Annotation more info
enables cGMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables cGMP binding	ISO Inferred from Sequence Orthology more info
enables intracellularly cAMP-activated cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables intracellularly cAMP-activated cation channel activity	ISO Inferred from Sequence Orthology more info
enables intracellularly cGMP-activated cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables intracellularly cGMP-activated cation channel activity	ISO Inferred from Sequence Orthology more info
enables intracellularly cyclic nucleotide-activated monoatomic cation channel activity	IEA Inferred from Electronic Annotation more info
enables intracellularly cyclic nucleotide-activated monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables monoatomic ion channel activity	TAS Traceable Author Statement more info	PubMed
enables protein-containing complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in monoatomic cation transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within sensory perception of smell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of intracellular cyclic nucleotide activated cation channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of intracellular cyclic nucleotide activated cation channel complex	ISO Inferred from Sequence Orthology more info
located_in non-motile cilium membrane	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: cyclic nucleotide-gated channel alpha-4; cyclic nucleotide-gated cation channel alpha-4

Names: CNG channel alpha-4; CNG-4; CNG4; cyclic nucleotide gated cation channel; olfactory cyclic nucleotide-gated channel; olfactory cyclic nucleotide-gated channel subunit 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033317.3 → NP_001028489.1 cyclic nucleotide-gated channel alpha-4

See identical proteins and their annotated locations for NP_001028489.1

Status: PROVISIONAL

Source sequence(s)

AC125055

Consensus CDS

CCDS21650.1

UniProtKB/Swiss-Prot

Q08EL1, Q3UW12

Related

ENSMUSP00000033187.5, ENSMUST00000033187.6

Conserved Domains (3) summary

cd00038
Location:348 → 464

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam00520
Location:34 → 273

Ion_trans; Ion transport protein

pfam16526
Location:464 → 534

CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

105049247..105057981

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017322183.3 → XP_017177672.1 cyclic nucleotide-gated cation channel alpha-4 isoform X1

UniProtKB/Swiss-Prot

Q08EL1, Q3UW12

Conserved Domains (3) summary

cd00038
Location:348 → 464

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam00520
Location:34 → 273

Ion_trans; Ion transport protein

pfam16526
Location:464 → 534

CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
XM_030242497.2 → XP_030098357.1 cyclic nucleotide-gated cation channel alpha-4 isoform X2

Related

ENSMUSP00000147387.2, ENSMUST00000210344.2

Conserved Domains (3) summary

PLN03192
Location:2 → 361

PLN03192; Voltage-dependent potassium channel; Provisional

cd00038
Location:245 → 361

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam16526
Location:361 → 431

CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels