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    Dennd2a DENN domain containing 2A [ Mus musculus (house mouse) ]

    Gene ID: 209773, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dennd2aprovided by MGI
    Official Full Name
    DENN domain containing 2Aprovided by MGI
    Primary source
    MGI:MGI:2444961
    See related
    Ensembl:ENSMUSG00000038456 AllianceGenome:MGI:2444961
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1277; C130031G22; B930096L08Rik
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in retrograde transport, endosome to Golgi. Predicted to be located in cytosol. Predicted to be active in actin cytoskeleton. Is expressed in cerebral cortex ventricular layer and head. Orthologous to human DENND2A (DENN domain containing 2A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 15.8), limb E14.5 (RPKM 12.4) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dennd2a in Genome Data Viewer
    Location:
    6 B1; 6 18.26 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (39439308..39535067, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (39462374..39558145, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene makorin, ring finger protein, 1 Neighboring gene STARR-seq mESC enhancer starr_15650 Neighboring gene predicted gene 10244 Neighboring gene predicted gene, 25402 Neighboring gene STARR-seq mESC enhancer starr_15653 Neighboring gene STARR-seq mESC enhancer starr_15655 Neighboring gene predicted gene, 52860 Neighboring gene STARR-seq mESC enhancer starr_15661 Neighboring gene RIKEN cDNA 8030453O22 gene Neighboring gene VISTA enhancer mm1321 Neighboring gene aarF domain containing kinase 2 Neighboring gene NADH:ubiquinone oxidoreductase subunit B2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry. Del Mar Masdeu M, et al. Oncotarget, 2017 Nov 24. PMID 29254152, Free PMC Article
    2. Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization. Powles N, et al. Dev Biol, 2004 Apr 1. PMID 15031102
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    4. KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility. Gu J, et al. Cell Death Differ, 2023 Jul. PMID 37142655, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in actin cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DENN domain-containing protein 2A
    Names
    DENN/MADD domain containing 2A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418005.1 → NP_001404934.1  DENN domain-containing protein 2A isoform a

      Status: VALIDATED

      Source sequence(s)
      AC122345, AC153624
      UniProtKB/Swiss-Prot
      Q3TJU2, Q3TUG3, Q3UXA3, Q8C4S8

    2. NM_001418006.1 → NP_001404935.1  DENN domain-containing protein 2A isoform b

      Status: VALIDATED

      Source sequence(s)
      AC122345, AC153624

    3. NM_001418007.1 → NP_001404936.1  DENN domain-containing protein 2A isoform b

      Status: VALIDATED

      Source sequence(s)
      AC122345, AC153624

    4. NM_001418008.1 → NP_001404937.1  DENN domain-containing protein 2A isoform c

      Status: VALIDATED

      Source sequence(s)
      AC122345, AC153624

    5. NM_172477.5 → NP_766065.1  DENN domain-containing protein 2A isoform a

      See identical proteins and their annotated locations for NP_766065.1

      Status: VALIDATED

      Source sequence(s)
      AC122345, AC153624
      Consensus CDS
      CCDS20023.1
      UniProtKB/Swiss-Prot
      Q3TJU2, Q3TUG3, Q3UXA3, Q8C4S8
      UniProtKB/TrEMBL
      B7ZP28
      Related
      ENSMUSP00000045367.4, ENSMUST00000036877.10
      Conserved Domains (3) summary
      smart00801
      Location:895 → 953
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:554 → 646
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:653 → 809
      DENN; DENN (AEX-3) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      39439308..39535067 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321485.3 → XP_017176974.1  DENN domain-containing protein 2A isoform X4

      UniProtKB/TrEMBL
      B7ZP28
      Conserved Domains (3) summary
      smart00801
      Location:957 → 1015
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:616 → 708
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:715 → 871
      DENN; DENN (AEX-3) domain

    2. XM_011241272.4 → XP_011239574.2  DENN domain-containing protein 2A isoform X2

      UniProtKB/TrEMBL
      B7ZP28
      Conserved Domains (3) summary
      smart00801
      Location:990 → 1048
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:649 → 741
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:748 → 904
      DENN; DENN (AEX-3) domain

    3. XM_011241273.4 → XP_011239575.2  DENN domain-containing protein 2A isoform X5

      UniProtKB/TrEMBL
      B7ZP28
      Conserved Domains (3) summary
      smart00801
      Location:924 → 982
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:583 → 675
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:682 → 838
      DENN; DENN (AEX-3) domain

    4. XM_017321484.3 → XP_017176973.1  DENN domain-containing protein 2A isoform X1

      UniProtKB/TrEMBL
      B7ZP28
      Conserved Domains (3) summary
      smart00801
      Location:991 → 1049
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:650 → 742
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:749 → 905
      DENN; DENN (AEX-3) domain

    5. XM_006505836.5 → XP_006505899.1  DENN domain-containing protein 2A isoform X3

      UniProtKB/TrEMBL
      B7ZP28
      Conserved Domains (3) summary
      smart00801
      Location:963 → 1021
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:622 → 714
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:721 → 877
      DENN; DENN (AEX-3) domain

    6. XM_030255296.2 → XP_030111156.1  DENN domain-containing protein 2A isoform X6

      UniProtKB/Swiss-Prot
      Q3TJU2, Q3TUG3, Q3UXA3, Q8C4S8
      UniProtKB/TrEMBL
      B7ZP28
      Conserved Domains (3) summary
      smart00801
      Location:895 → 953
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:554 → 646
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:653 → 809
      DENN; DENN (AEX-3) domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C4S8.1 GenPept UniProtKB/Swiss-Prot:Q8C4S8

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