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    Retsat retinol saturase (all trans retinol 13,14 reductase) [ Mus musculus (house mouse) ]

    Gene ID: 67442, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Retsatprovided by MGI
    Official Full Name
    retinol saturase (all trans retinol 13,14 reductase)provided by MGI
    Primary source
    MGI:MGI:1914692
    See related
    Ensembl:ENSMUSG00000056666 AllianceGenome:MGI:1914692
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MMT-7; Ppsig; 0610039N19Rik
    Summary
    Enables all-trans-retinol 13,14-reductase activity. Involved in retinol metabolic process. Located in endoplasmic reticulum membrane and nuclear outer membrane. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system gland; and nervous system. Orthologous to human RETSAT (retinol saturase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver adult (RPKM 119.1), kidney adult (RPKM 90.0) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Retsat in Genome Data Viewer
    Location:
    6 C1; 6 32.27 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (72575585..72584471)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (72598602..72607488)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6442 Neighboring gene capping actin protein, gelsolin like Neighboring gene ELMO/CED-12 domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E4833 Neighboring gene STARR-positive B cell enhancer ABC_E6443 Neighboring gene trans-golgi network protein Neighboring gene predicted gene 15401 Neighboring gene transcription factor 7 like 1 (T cell specific, HMG box)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regenerating Skeletal Muscle Compensates for the Impaired Macrophage Functions Leading to Normal Muscle Repair in Retinol Saturase Null Mice. Tarban N, et al. Cells, 2022 Apr 13. PMID 35456012, Free PMC Article
    2. RETSAT Mutation Selected for Hypoxia Adaptation Inhibits Tumor Growth. Jiang X, et al. Front Cell Dev Biol, 2021. PMID 34805153, Free PMC Article
    3. Retinol Saturase Knock-Out Mice are Characterized by Impaired Clearance of Apoptotic Cells and Develop Mild Autoimmunity. Sarang Z, et al. Biomolecules, 2019 Nov 13. PMID 31766264, Free PMC Article
    4. Retinol saturase modulates lipid metabolism and the production of reactive oxygen species. Pang XY, et al. Arch Biochem Biophys, 2017 Nov 1. PMID 28927883, Free PMC Article
    5. An RNAi-based genetic screen for oxidative stress resistance reveals retinol saturase as a mediator of stress resistance. Nagaoka-Yasuda R, et al. Free Radic Biol Med, 2007 Sep 1. PMID 17664141

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Intestinal retinol saturase is implicated in the development of obesity and epithelial homeostasis upon injury.
      Title: Intestinal retinol saturase is implicated in the development of obesity and epithelial homeostasis upon injury.
    2. Retsat modulates lipid metabolism and the production of reactive oxygen species.
      Title: Retinol saturase modulates lipid metabolism and the production of reactive oxygen species.
    3. Increased adiposity in the retinol saturase-knockout mouse.
      Title: Increased adiposity in the retinol saturase-knockout mouse.
    4. RetSat-deficiency is associated with alterations in lipid metabolism and the in vivo adipogenic program.
      Title: Increased adiposity in the retinol saturase-knockout mouse.
    5. Mouse RetSat catalyzes the stereospecific saturation of the C13-C14 double bond of all-trans-retinol to produce (13R)-all-trans-13,14-dihydroretinol.
      Title: Stereospecificity of retinol saturase: absolute configuration, synthesis, and biological evaluation of dihydroretinoids.
    6. RetSat plays an important role in the biology of adipocytes, where it favors normal differentiation, yet is reduced in the obese state.
      Title: Retinol saturase promotes adipogenesis and is downregulated in obesity.
    7. Here, we report the identification and characterization of Ppsig (for PPARalpha-regulated and starvation-induced gene) with unknown biological function from mouse liver
      Title: Identification and characterization of a novel mouse peroxisome proliferator-activated receptor alpha-regulated and starvation-induced gene, Ppsig.
    8. suggest a novel role for retinol saturase in regulating sensitivity to oxidative stress
      Title: An RNAi-based genetic screen for oxidative stress resistance reveals retinol saturase as a mediator of stress resistance.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (5)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC143538

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables all-trans-retinol 13,14-reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables all-trans-retinol 13,14-reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables all-trans-retinol 13,14-reductase activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in retinoid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in retinol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retinol metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    all-trans-retinol 13,14-reductase
    Names
    PPAR-alpha-regulated and starvation-induced gene protein
    all-trans-13,14-dihydroretinol saturase
    NP_080435.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026159.5 → NP_080435.3  all-trans-retinol 13,14-reductase precursor

      See identical proteins and their annotated locations for NP_080435.3

      Status: VALIDATED

      Source sequence(s)
      AC125039
      Consensus CDS
      CCDS20244.1
      UniProtKB/Swiss-Prot
      Q149J8, Q3UNN9, Q64FW2, Q78JX8, Q8VHE7, Q9CW85
      UniProtKB/TrEMBL
      A4FUU4
      Related
      ENSMUSP00000068568.7, ENSMUST00000070597.13
      Conserved Domains (2) summary
      COG1233
      Location:68 → 566
      COG1233; Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism]
      cl21454
      Location:68 → 568
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      72575585..72584471
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64FW2.3 GenPept UniProtKB/Swiss-Prot:Q64FW2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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