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    Sh2d5 SH2 domain containing 5 [ Mus musculus (house mouse) ]

    Gene ID: 230863, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sh2d5provided by MGI
    Official Full Name
    SH2 domain containing 5provided by MGI
    Primary source
    MGI:MGI:2446215
    See related
    Ensembl:ENSMUSG00000045349 AllianceGenome:MGI:2446215
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Located in postsynaptic density. Orthologous to human SH2D5 (SH2 domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 20.0), frontal lobe adult (RPKM 15.1) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Sh2d5 in Genome Data Viewer
    Location:
    4 D3; 4 70.07 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (137977722..137988279)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (138250411..138260968)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4 gamma, 3 Neighboring gene microRNA 6399 Neighboring gene heterochromatin protein 1, binding protein 3 Neighboring gene predicted gene, 54278 Neighboring gene STARR-positive B cell enhancer ABC_E8002 Neighboring gene kinesin family member 17 Neighboring gene STARR-positive B cell enhancer ABC_E4692 Neighboring gene dolichyl-di-phosphooligosaccharide-protein glycotransferase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    General gene information

    Potential readthrough

    Included gene: Kif17

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    SH2 domain-containing protein 5
    Names
    vascular SH2 domain-containing protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099631.2NP_001093101.1  SH2 domain-containing protein 5

      See identical proteins and their annotated locations for NP_001093101.1

      Status: VALIDATED

      Source sequence(s)
      AL807249
      Consensus CDS
      CCDS51335.1
      UniProtKB/Swiss-Prot
      Q8JZW5
      UniProtKB/TrEMBL
      A2AM67
      Related
      ENSMUSP00000101450.2, ENSMUST00000105824.8
      Conserved Domains (2) summary
      cd00173
      Location:302378
      SH2; Src homology 2 (SH2) domain
      cd13157
      Location:23150
      PTB_tensin-related; Tensin-related Phosphotyrosine-binding (PTB) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      137977722..137988279
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)