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    Skint2 selection and upkeep of intraepithelial T cells 2 [ Mus musculus (house mouse) ]

    Gene ID: 329919, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Skint2provided by MGI
    Official Full Name
    selection and upkeep of intraepithelial T cells 2provided by MGI
    Primary source
    MGI:MGI:3649629
    See related
    Ensembl:ENSMUSG00000034359 AllianceGenome:MGI:3649629
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B7S3; Skint-2; A430070M19
    Summary
    Predicted to enable signaling receptor binding activity. Predicted to be involved in T cell receptor signaling pathway and regulation of cytokine production. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including genitourinary system; gut; integumental system; liver; and thymus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Skint2 in Genome Data Viewer
    Location:
    4 D1; 4 51.53 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (112470917..112509447)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (112613598..112652248)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene deoxynucleotidyltransferase terminal-interacting protein 1 pseudogene Neighboring gene predicted gene 12814 Neighboring gene predicted gene, 24099 Neighboring gene predicted gene 12817 Neighboring gene STARR-seq mESC enhancer starr_11100 Neighboring gene selection and upkeep of intraepithelial T cells 10 Neighboring gene TRAF3 interacting protein 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of B7S3 as a novel negative regulator of T cells. Yang Y, et al. J Immunol, 2007 Mar 15. PMID 17339463
    2. Skint-1 is a highly specific, unique selecting component for epidermal T cells. Barbee SD, et al. Proc Natl Acad Sci U S A, 2011 Feb 22. PMID 21300860, Free PMC Article
    3. Butyrophilin-like proteins display combinatorial diversity in selecting and maintaining signature intraepithelial γδ T cell compartments. Jandke A, et al. Nat Commun, 2020 Jul 28. PMID 32724083, Free PMC Article
    4. Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal gammadelta T cells. Boyden LM, et al. Nat Genet, 2008 May. PMID 18408721, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    selection and upkeep of intraepithelial T-cells protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285963.2 → NP_001272892.1  selection and upkeep of intraepithelial T-cells protein 2 isoform a precursor

      See identical proteins and their annotated locations for NP_001272892.1

      Status: VALIDATED

      Source sequence(s)
      AL645508
      Consensus CDS
      CCDS38840.2
      UniProtKB/Swiss-Prot
      A7TZE8, A7TZE9, A7XUX6, A7XUY1
      Related
      ENSMUSP00000139831.2, ENSMUST00000186969.2
      Conserved Domains (3) summary
      cd05713
      Location:39 → 138
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      smart00410
      Location:31 → 137
      IG_like; Immunoglobulin like
      cl11960
      Location:156 → 218
      Ig; Immunoglobulin domain

    2. NM_001285965.2 → NP_001272894.1  selection and upkeep of intraepithelial T-cells protein 2 isoform b precursor

      See identical proteins and their annotated locations for NP_001272894.1

      Status: VALIDATED

      Source sequence(s)
      AL645508
      UniProtKB/Swiss-Prot
      A7XUX6
      Conserved Domains (3) summary
      cd05713
      Location:39 → 138
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      smart00410
      Location:31 → 137
      IG_like; Immunoglobulin like
      cl11960
      Location:156 → 218
      Ig; Immunoglobulin domain

    3. NM_001425821.1 → NP_001412750.1  selection and upkeep of intraepithelial T-cells protein 2 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL645508
      UniProtKB/TrEMBL
      B2ZEZ5, E9Q127
      Related
      ENSMUSP00000102170.4, ENSMUST00000106560.10

    4. NM_001425822.1 → NP_001412751.1  selection and upkeep of intraepithelial T-cells protein 2 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AL645508
      UniProtKB/TrEMBL
      M9MMJ5, Q8CG82
      Related
      ENSMUSP00000061011.8, ENSMUST00000058791.14

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      112470917..112509447
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320265.1 → XP_017175754.1  selection and upkeep of intraepithelial T-cells protein 2 isoform X3

      Conserved Domains (4) summary
      cd05713
      Location:43 → 142
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      cd14964
      Location:245 → 265
      7tm_GPCRs; TM helix 4 [structural motif]
      cl11960
      Location:155 → 243
      Ig; Immunoglobulin domain
      cl28897
      Location:199 → 308
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177865.4: Suppressed sequence

      Description
      NM_177865.4: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A7XUX6.1 GenPept UniProtKB/Swiss-Prot:A7XUX6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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