Mttp microsomal triglyceride transfer protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mttpprovided by MGI
Official Full Name: microsomal triglyceride transfer proteinprovided by MGI
Primary source: MGI:MGI:106926
See related: Ensembl:ENSMUSG00000028158 AllianceGenome:MGI:106926
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MTP; 1810043K16Rik
Summary: Enables cholesterol transfer activity; phosphatidylethanolamine transfer activity; and triglyceride transfer activity. Involved in circadian rhythm. Acts upstream of or within several processes, including cholesterol homeostasis; lipoprotein transport; and low-density lipoprotein particle remodeling. Located in endoplasmic reticulum. Is expressed in several structures, including gut; liver; placenta; septum transversum hepatic component; and yolk sac. Human ortholog(s) of this gene implicated in several diseases, including abetalipoproteinemia; familial hypercholesterolemia; hyperinsulinism; metabolic dysfunction-associated steatotic liver disease; and obesity. Orthologous to human MTTP (microsomal triglyceride transfer protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in large intestine adult (RPKM 62.5), duodenum adult (RPKM 33.4) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 G3; 3 64.06 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (137795616..137849179, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (138089855..138143418, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Microsomal triglyceride transfer protein is necessary to maintain lipid homeostasis and retinal function.
Title: Microsomal triglyceride transfer protein is necessary to maintain lipid homeostasis and retinal function.
Conditional hepatocyte ablation of PDIA1 uncovers indispensable roles in both APOB and MTTP folding to support VLDL secretion.
Title: Conditional hepatocyte ablation of PDIA1 uncovers indispensable roles in both APOB and MTTP folding to support VLDL secretion.
Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion.
Title: Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion.
Microsomal triglyceride transfer protein regulates intracellular lipolysis in adipocytes independent of its lipid transfer activity.
Title: Microsomal triglyceride transfer protein regulates intracellular lipolysis in adipocytes independent of its lipid transfer activity.
PRAP1 is a novel lipid-binding protein that promotes lipid absorption by facilitating MTTP-mediated lipid transport.
Title: PRAP1 is a novel lipid-binding protein that promotes lipid absorption by facilitating MTTP-mediated lipid transport.
MTTP may play an important role for the heart function in conjunction to ischemic events.
Title: Cardiac expression of the microsomal triglyceride transport protein protects the heart function during ischemia.
The anti-sense strand of the mouse Mttp gene contains one noncoding RNA.
Title: Identification of antisense transcripts of the microsomal triglyceride transfer protein genes in humans and mice.
microsomal triglyceride transfer protein, a protein involved in the transfer of lipids onto CD1d, regulates liver natural killer T cell homeostasis in a manner dependent on hepatocyte CD1d.
Title: CD1d-Restricted pathways in hepatocytes control local natural killer T cell homeostasis and hepatic inflammation.
Microsomal triglyceride transfer protein protein plays a critical role in lipid droplet maturation, but does not regulate total body fat accumulation.
Title: Microsomal triglyceride transfer protein contributes to lipid droplet maturation in adipocytes.
data provide the first in vivo evidence of the transcriptional regulatory activity of beta-apocarotenoids and identify microsomal triglyceride transfer protein and its transcription factors as the targets of their action. This study demonstrates that beta-carotene induces a feed-forward mechanism in the placenta to enhance the assimilation of beta-carotene for proper embryogenesis.
Title: β-Apo-10'-carotenoids Modulate Placental Microsomal Triglyceride Transfer Protein Expression and Function to Optimize Transport of Intact β-Carotene to the Embryo.

Submit: New GeneRIF Correction See all GeneRIFs (49)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234833

Mttp (e-PCR), detects polymorphism
- UniSTS:526219

Mttp (e-PCR), detects polymorphism
- UniSTS:259503

L47970 (e-PCR)
- UniSTS:178939

AI605416 (e-PCR)
- UniSTS:178940

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables apolipoprotein binding	IEA Inferred from Electronic Annotation more info
enables apolipoprotein binding	ISO Inferred from Sequence Orthology more info
enables ceramide 1-phosphate transfer activity	ISS Inferred from Sequence or Structural Similarity more info
enables cholesterol transfer activity	IDA Inferred from Direct Assay more info	PubMed
enables cholesterol transfer activity	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables lipid transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables lipid transporter activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine transfer activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylcholine transfer activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylethanolamine transfer activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylethanolamine transfer activity	ISO Inferred from Sequence Orthology more info
enables phospholipid transfer activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipid transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables triglyceride transfer activity	IDA Inferred from Direct Assay more info	PubMed
enables triglyceride transfer activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ceramide 1-phosphate transport	IEA Inferred from Electronic Annotation more info
involved_in cholesterol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cholesterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intermembrane lipid transfer	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid transport	ISO Inferred from Sequence Orthology more info
involved_in lipoprotein metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipoprotein metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipoprotein metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipoprotein transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within low-density lipoprotein particle remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipid transport	ISO Inferred from Sequence Orthology more info
involved_in phospholipid transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in plasma lipoprotein particle assembly	ISO Inferred from Sequence Orthology more info
involved_in plasma lipoprotein particle assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein lipidation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein secretion	ISO Inferred from Sequence Orthology more info
involved_in protein secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in sterol transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within triglyceride metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in triglyceride transport	ISO Inferred from Sequence Orthology more info
involved_in triglyceride transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	IEA Inferred from Electronic Annotation more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in microvillus membrane	IEA Inferred from Electronic Annotation more info
located_in microvillus membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed
located_in vesicle	IEA Inferred from Electronic Annotation more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: microsomal triglyceride transfer protein large subunit

Names: microsomal triglyceride transfer protein B; microsomal triglyceride transfer protein, large subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163457.2 → NP_001156929.1 microsomal triglyceride transfer protein large subunit isoform 1 precursor

See identical proteins and their annotated locations for NP_001156929.1

Status: VALIDATED

Source sequence(s)

AC131122, AK136278, AK146553

Consensus CDS

CCDS51080.1

UniProtKB/Swiss-Prot

O08601

Related

ENSMUSP00000096179.3, ENSMUST00000098580.6

Conserved Domains (1) summary

cl26969
Location:43 → 594

Vitellogenin_N; Lipoprotein amino terminal region
NM_001355051.1 → NP_001341980.1 microsomal triglyceride transfer protein large subunit isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC131122

Consensus CDS

CCDS38650.1

UniProtKB/Swiss-Prot

B2CXA7, O08601, Q3UJA0, Q91X33

Conserved Domains (1) summary

cl26969
Location:28 → 579

Vitellogenin_N; Lipoprotein amino terminal region
NM_001355052.1 → NP_001341981.1 microsomal triglyceride transfer protein large subunit isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC131122

Consensus CDS

CCDS38650.1

UniProtKB/Swiss-Prot

B2CXA7, O08601, Q3UJA0, Q91X33

Conserved Domains (1) summary

cl26969
Location:28 → 579

Vitellogenin_N; Lipoprotein amino terminal region
NM_008642.3 → NP_032668.2 microsomal triglyceride transfer protein large subunit isoform 2 precursor

See identical proteins and their annotated locations for NP_032668.2

Status: VALIDATED

Source sequence(s)

AC131122, AK146553

Consensus CDS

CCDS38650.1

UniProtKB/Swiss-Prot

B2CXA7, O08601, Q3UJA0, Q91X33

Related

ENSMUSP00000029805.9, ENSMUST00000029805.13

Conserved Domains (1) summary

cl26969
Location:28 → 579

Vitellogenin_N; Lipoprotein amino terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

137795616..137849179 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006501102.4 → XP_006501165.1 microsomal triglyceride transfer protein large subunit isoform X1

See identical proteins and their annotated locations for XP_006501165.1

UniProtKB/Swiss-Prot

O08601

Conserved Domains (1) summary

cl26969
Location:43 → 594

Vitellogenin_N; Lipoprotein amino terminal region
XM_006501103.4 → XP_006501166.1 microsomal triglyceride transfer protein large subunit isoform X2

See identical proteins and their annotated locations for XP_006501166.1

UniProtKB/Swiss-Prot

B2CXA7, O08601, Q3UJA0, Q91X33

Conserved Domains (1) summary

cl26969
Location:28 → 579

Vitellogenin_N; Lipoprotein amino terminal region