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    Clic3 chloride intracellular channel 3 [ Mus musculus (house mouse) ]

    Gene ID: 69454, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Clic3provided by MGI
    Official Full Name
    chloride intracellular channel 3provided by MGI
    Primary source
    MGI:MGI:1916704
    See related
    Ensembl:ENSMUSG00000015093 AllianceGenome:MGI:1916704
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2300003G24Rik
    Summary
    Predicted to enable chloride channel activity and protein-disulfide reductase (glutathione) activity. Predicted to be involved in chloride transport and positive regulation of sprouting angiogenesis. Predicted to be located in extracellular matrix and nuclear body. Predicted to be part of chloride channel complex. Predicted to be active in cytoplasm and membrane. Is expressed in metanephros visceral epithelium. Orthologous to human CLIC3 (chloride intracellular channel 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in lung adult (RPKM 601.4), stomach adult (RPKM 133.5) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Clic3 in Genome Data Viewer
    Location:
    2 A3; 2 17.27 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25346855..25348789)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25456843..25458777)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene fucosyltransferase 7 Neighboring gene ATP-binding cassette, sub-family A member 2 Neighboring gene microRNA 3087 Neighboring gene STARR-positive B cell enhancer ABC_E2604 Neighboring gene non-homologous end joining factor Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:25321339-25321522 Neighboring gene prostaglandin D2 synthase (brain) Neighboring gene predicted gene, 35287

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CRIg signals induce anti-intracellular bacterial phagosome activity in a chloride intracellular channel 3-dependent manner. Kim KH, et al. Eur J Immunol, 2013 Mar. PMID 23280470
    2. Molecular detection of maturation stages in the developing kidney. Naganuma H, et al. Dev Biol, 2021 Feb. PMID 33197428
    3. Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Lefebvre J, et al. Kidney Int, 2015 Aug. PMID 25993318
    4. Accelerating functional gene discovery in osteoarthritis. Butterfield NC, et al. Nat Commun, 2021 Jan 20. PMID 33473114, Free PMC Article
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CRIg signals induce anti-intracellular bacterial phagosome activity in a chloride intracellular channel 3-dependent manner.
      Title: CRIg signals induce anti-intracellular bacterial phagosome activity in a chloride intracellular channel 3-dependent manner.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chloride channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chloride channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-disulfide reductase (glutathione) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-disulfide reductase (glutathione) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chloride transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chloride transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of chloride channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    chloride intracellular channel protein 3
    Names
    glutaredoxin-like oxidoreductase CLIC3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027085.3 → NP_081361.1  chloride intracellular channel protein 3

      See identical proteins and their annotated locations for NP_081361.1

      Status: PROVISIONAL

      Source sequence(s)
      AL732557
      Consensus CDS
      CCDS15774.1
      UniProtKB/Swiss-Prot
      Q9D7P7
      UniProtKB/TrEMBL
      A2AJ28
      Related
      ENSMUSP00000109904.3, ENSMUST00000114265.9
      Conserved Domains (3) summary
      TIGR00862
      Location:6 → 230
      O-ClC; intracellular chloride channel protein
      cd10299
      Location:99 → 231
      GST_C_CLIC3; C-terminal, alpha helical domain of Chloride Intracellular Channel 3
      cd03061
      Location:3 → 92
      GST_N_CLIC; GST_N family, Chloride Intracellular Channel (CLIC) subfamily; composed of CLIC1-5, p64, parchorin and similar proteins. They are auto-inserting, self-assembling intracellular anion channels involved in a wide variety of functions including regulated ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      25346855..25348789
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252050.2 → XP_030107910.1  chloride intracellular channel protein 3 isoform X1

      UniProtKB/TrEMBL
      A2AJ28
      Conserved Domains (1) summary
      TIGR00862
      Location:43 → 261
      O-ClC; intracellular chloride channel protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D7P7.2 GenPept UniProtKB/Swiss-Prot:Q9D7P7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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