Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyp2c65provided by MGI
Official Full Name: cytochrome P450, family 2, subfamily c, polypeptide 65provided by MGI
Primary source: MGI:MGI:1919553
See related: Ensembl:ENSMUSG00000067231 AllianceGenome:MGI:1919553
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2210009K14Rik
Summary: Predicted to enable caffeine oxidase activity; heme binding activity; and monooxygenase activity. Predicted to be involved in epoxygenase P450 pathway and xenobiotic metabolic process. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including end stage renal disease; glucose metabolism disease (multiple); head and neck squamous cell carcinoma; hypertension (multiple); and warfarin resistance. Orthologous to human CYP2C8 (cytochrome P450 family 2 subfamily C member 8) and CYP2C9 (cytochrome P450 family 2 subfamily C member 9). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in duodenum adult (RPKM 72.3), small intestine adult (RPKM 34.5) and 3 other tissues See more
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Genomic context

Location:: 19 C3; 19 33.7 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (39049450..39082392)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (39061006..39093948)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

NoName (e-PCR)
- UniSTS:493354

Cyp2c65 (e-PCR), detects polymorphism
- UniSTS:546722

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables arachidonate epoxygenase activity	ISO Inferred from Sequence Orthology more info
enables caffeine oxidase activity	ISO Inferred from Sequence Orthology more info
enables estrogen 16-alpha-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info
enables retinoic acid 4-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables steroid hydroxylase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in organic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytochrome P450, family 2, subfamily c, polypeptide 65

Names: cytochrome P450, 2c65

NP_082467.2

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.