A1cf APOBEC1 complementation factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: A1cfprovided by MGI
Official Full Name: APOBEC1 complementation factorprovided by MGI
Primary source: MGI:MGI:1917115
See related: Ensembl:ENSMUSG00000052595 AllianceGenome:MGI:1917115
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ASP; Acf; MCM; mer; ACF64; ACF65; MerCreMer; 1810073H04Rik; 9130016M20Rik; alpha-MHC-MerCreMer; alphaMHC-Cre-Mer-Cre; Tg(Myh6-cre/Esr1*)1Jmk
Summary: Predicted to enable enzyme-substrate adaptor activity; mRNA binding activity; and single-stranded RNA binding activity. Involved in cytidine to uridine editing. Acts upstream of or within embryo implantation; mRNA localization resulting in post-transcriptional regulation of gene expression; and mRNA modification. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; gonad; liver; and sensory organ. Human ortholog(s) of this gene implicated in gout. Orthologous to human A1CF (APOBEC1 complementation factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver adult (RPKM 13.0), liver E18 (RPKM 9.1) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19; 19 C1

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (31846156..31929765)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (31868756..31952365)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Apobec1 complementation factor overexpression promotes hepatic steatosis, fibrosis, and hepatocellular cancer.
Title: Apobec1 complementation factor overexpression promotes hepatic steatosis, fibrosis, and hepatocellular cancer.
The RNA-Binding Protein A1CF Regulates Hepatic Fructose and Glycerol Metabolism via Alternative RNA Splicing.
Title: The RNA-Binding Protein A1CF Regulates Hepatic Fructose and Glycerol Metabolism via Alternative RNA Splicing.
A1CF and RBM47 each function independently, yet interact in a tissue-specific manner, to regulate the activity and site selection of APOBEC1 dependent C-to-U RNA editing.
Title: Apobec1 complementation factor (A1CF) and RBM47 interact in tissue-specific regulation of C to U RNA editing in mouse intestine and liver.
Here, we show that partial loss of either APOBEC1 complementation factor (A1CF), the RNA-binding cofactor of APOBEC1 in RNA editing, or Argonaute 2 (AGO2), a key factor in the biogenesis of certain noncoding RNAs, modulates risk for TGCTs and testicular abnormalities in both parent-of-origin and conventional genetic manners.
Title: Parent-of-origin effects of A1CF and AGO2 on testicular germ-cell tumors, testicular abnormalities, and fertilization bias.
The observations demonstrate that A1CF does not act as the APOBEC1 complementation factor in vivo under normal physiological conditions and suggest new roles for A1CF, specifically within the male adult kidney.
Title: APOBEC1 complementation factor (A1CF) is dispensable for C-to-U RNA editing in vivo.
Data show that the importance of ACF for modulating ApoB was supported by the finding that RNAi knockdown of ACF reduced ApoB secretion.
Title: Metabolic regulation of APOBEC-1 complementation factor trafficking in mouse models of obesity and its positive correlation with the expression of ApoB protein in hepatocytes.
ACF regulates liver regeneration following partial hepatectomy at least in part by controlling the stability of IL-6 mRNA
Title: Apobec-1 complementation factor modulates liver regeneration by post-transcriptional regulation of interleukin-6 mRNA stability.
ACF plays a crucial role, which is independent of apobec-1 expression, in cell survival, particularly during early embryonic development
Title: Targeted deletion of the murine apobec-1 complementation factor (acf) gene results in embryonic lethality.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation
Transgenic (1) 1 citation

General gene information

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Markers

1810073H04Rik (e-PCR), detects polymorphism
- UniSTS:478976

D0M19Mit135 (e-PCR)
- UniSTS:128350

D19Mit135 (e-PCR), detects polymorphism
- UniSTS:128350

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	TAS Traceable Author Statement more info	PubMed
NOT enables double-stranded RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme-substrate adaptor activity	IEA Inferred from Electronic Annotation more info
enables enzyme-substrate adaptor activity	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables single-stranded RNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in chromosomal 5-methylcytosine DNA demethylation pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in cytidine to uridine editing	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cytidine to uridine editing	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cytidine to uridine editing	ISO Inferred from Sequence Orthology more info
involved_in cytidine to uridine editing	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within embryo implantation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mRNA localization resulting in post-transcriptional regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within mRNA modification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mRNA modification	ISO Inferred from Sequence Orthology more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of apolipoprotein B mRNA editing enzyme complex	ISO Inferred from Sequence Orthology more info
part_of apolipoprotein B mRNA editing enzyme complex	ISS Inferred from Sequence or Structural Similarity more info
part_of apolipoprotein B mRNA editing enzyme complex	TAS Traceable Author Statement more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in heterochromatin	ISO Inferred from Sequence Orthology more info
part_of mRNA editing complex	ISO Inferred from Sequence Orthology more info
part_of mRNA editing complex	NAS Non-traceable Author Statement more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: APOBEC1 complementation factor

Names: APOBEC-1 stimulating protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081074.2 → NP_001074543.1 APOBEC1 complementation factor isoform 1

See identical proteins and their annotated locations for NP_001074543.1

Status: VALIDATED

Source sequence(s)

AC117816, AC125019

Consensus CDS

CCDS37959.1

UniProtKB/Swiss-Prot

E9QJS8, Q5FW55, Q5YD47, Q5YD48

Related

ENSMUSP00000075235.6, ENSMUST00000075838.8

Conserved Domains (1) summary

TIGR01648
Location:2 → 595

hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
NM_001365078.1 → NP_001352007.1 APOBEC1 complementation factor isoform 2

Status: VALIDATED

Source sequence(s)

AC117816, AC125019

Consensus CDS

CCDS89374.1

Related

ENSMUSP00000153542.2, ENSMUST00000224304.2

Conserved Domains (1) summary

TIGR01648
Location:2 → 587

hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

31846156..31929765

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017318290.2 → XP_017173779.1 APOBEC1 complementation factor isoform X1

Conserved Domains (1) summary

TIGR01648
Location:1 → 511

hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family