Wdr43 WD repeat domain 43 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wdr43provided by MGI
Official Full Name: WD repeat domain 43provided by MGI
Primary source: MGI:MGI:1919765
See related: Ensembl:ENSMUSG00000041057 AllianceGenome:MGI:1919765
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Wrd43; mKIAA0007; 2610318G08Rik
Summary: Enables RNA polymerase II complex binding activity and transcription elongation factor activity. Involved in regulation of stem cell population maintenance and regulation of transcription elongation by RNA polymerase II. Located in chromatin; nucleolus; and nucleoplasm. Is expressed in several structures, including alimentary system; axial musculature; clavicle; oocyte; and submandibular gland primordium. Orthologous to human WDR43 (WD repeat domain 43). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in CNS E11.5 (RPKM 16.3), liver E14 (RPKM 11.3) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 E1.3; 17 41.87 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (71923175..71966026)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (71616178..71659031)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNA targets ribogenesis Factor WDR43 to chromatin for transcription and pluripotency control.
Title: RNA Targets Ribogenesis Factor WDR43 to Chromatin for Transcription and Pluripotency Control.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AV024208 (e-PCR)
- UniSTS:181057

NoName (e-PCR)
- UniSTS:237688

RH136331 (e-PCR)
- UniSTS:210321

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II complex binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription elongation factor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of rRNA processing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase I	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase I	ISO Inferred from Sequence Orthology more info
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in regulation of stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription elongation by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosomal small subunit biogenesis	ISO Inferred from Sequence Orthology more info
involved_in ribosomal small subunit biogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of small-subunit processome	ISO Inferred from Sequence Orthology more info
part_of small-subunit processome	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: WD repeat-containing protein 43

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175639.1 → NP_783570.1 WD repeat-containing protein 43

See identical proteins and their annotated locations for NP_783570.1

Status: VALIDATED

Source sequence(s)

AK129031, AK152321, BY736005

Consensus CDS

CCDS50180.1

UniProtKB/Swiss-Prot

Q3U895, Q6ZQL4

UniProtKB/TrEMBL

Q68FC6

Related

ENSMUSP00000048337.10, ENSMUST00000047086.10

Conserved Domains (4) summary

COG2319
Location:19 → 217

WD40; WD40 repeat [General function prediction only]

pfam04003
Location:472 → 568

Utp12; Dip2/Utp12 Family

sd00039
Location:19 → 57

7WD40; WD40 repeat [structural motif]

cl02567
Location:19 → 271

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...