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    Rnu12 RNA U12, small nuclear [ Mus musculus (house mouse) ]

    Gene ID: 104307, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rnu12provided by MGI
    Official Full Name
    RNA U12, small nuclearprovided by MGI
    Primary source
    MGI:MGI:1336893
    See related
    Ensembl:ENSMUSG00000065176 AllianceGenome:MGI:1336893
    Gene type
    snRNA
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Involved in negative regulation of neuron apoptotic process. Acts upstream of or within RNA splicing. Is expressed in several structures, including branchial arch; limb; limb primordium; neural retina; and somite. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See Rnu12 in Genome Data Viewer
    Location:
    15 E1; 15 39.4 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (83033846..83033995)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (83149645..83149794)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene serine hydrolase-like Neighboring gene ribosomal RNA processing 7 homolog A Neighboring gene polymerase (DNA-directed), delta interacting protein 3 Neighboring gene cytochrome b5 reductase 3 Neighboring gene STARR-positive B cell enhancer ABC_E4142 Neighboring gene STARR-seq mESC enhancer starr_39316 Neighboring gene STARR-seq mESC enhancer starr_39317 Neighboring gene STARR-seq mESC enhancer starr_39321 Neighboring gene alpha 1,4-galactosyltransferase Neighboring gene STARR-positive B cell enhancer ABC_E5503

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Minor splicing snRNAs are enriched in the developing mouse CNS and are crucial for survival of differentiating retinal neurons. Baumgartner M, et al. Dev Neurobiol, 2015 Sep. PMID 25492806
    2. U12 snRNA in vertebrates: evolutionary conservation of 5' sequences implicated in splicing of pre-mRNAs containing a minor class of introns. Tarn WY, et al. RNA, 1995 Aug. PMID 7489523, Free PMC Article
    3. The divergent U12-type spliceosome is required for pre-mRNA splicing and is essential for development in Drosophila. Otake LR, et al. Mol Cell, 2002 Feb. PMID 11864616
    4. Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns. Olthof AM, et al. Nucleic Acids Res, 2021 Apr 6. PMID 33660780, Free PMC Article
    5. Minor spliceosome components are predominantly localized in the nucleus. Pessa HK, et al. Proc Natl Acad Sci U S A, 2008 Jun 24. PMID 18559850, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_004432.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591952
      Related
      ENSMUST00000083242.3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      83033846..83033995
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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