Mpp2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mpp2provided by MGI
Official Full Name: membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)provided by MGI
Primary source: MGI:MGI:1858257
See related: Ensembl:ENSMUSG00000017314 AllianceGenome:MGI:1858257
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dlg2; Dlgh2; Pals4; D11Bwg0652e
Summary: Enables transmembrane transporter binding activity. A structural constituent of postsynaptic density. Involved in excitatory postsynaptic potential and long-term synaptic potentiation. Located in dendrite membrane; dendritic shaft; and dendritic spine. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut gland; respiratory system; and retina. Orthologous to human MPP2 (MAGUK p55 scaffold protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in frontal lobe adult (RPKM 33.8), cortex adult (RPKM 27.2) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 65.48 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (101947841..101979464, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (102057015..102088638, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MPP2 interacts with SK2 to rescue the excitability of glutamatergic neurons in the BLA and facilitate the extinction of conditioned fear in mice.
Title: MPP2 interacts with SK2 to rescue the excitability of glutamatergic neurons in the BLA and facilitate the extinction of conditioned fear in mice.
Involvement of membrane palmitoylated protein 2 (MPP2) in the synaptic molecular complex at the mouse cerebellar glomerulus.
Title: Involvement of membrane palmitoylated protein 2 (MPP2) in the synaptic molecular complex at the mouse cerebellar glomerulus.
Thus, MPP2 is a novel synaptic scaffold that is required for proper synaptic localization and function of SK2-containing channels.
Title: Membrane palmitoylated protein 2 is a synaptic scaffold protein required for synaptic SK2-containing channel function.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MDB0652 (e-PCR)
- UniSTS:125030

D11Bwg0652e (e-PCR), detects polymorphism
- UniSTS:141722

MARC_16305-16306:1028219005:5 (e-PCR)
- UniSTS:267995

BE119088 (e-PCR)
- UniSTS:249084

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of postsynaptic density	IEP Inferred from Expression Pattern more info	PubMed
enables structural constituent of postsynaptic density	IMP Inferred from Mutant Phenotype more info	PubMed
enables structural constituent of postsynaptic density	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of postsynaptic density structure	IEA Inferred from Electronic Annotation more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite membrane	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic shaft	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: MAGUK p55 subfamily member 2

Names: discs large homolog 2; p55 subfamily member of MAGUK family

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356324.2 → NP_001343253.1 MAGUK p55 subfamily member 2 isoform 1

Status: VALIDATED

Source sequence(s)

AL591145

Consensus CDS

CCDS88261.1

Related

ENSMUSP00000097967.5, ENSMUST00000100398.5

Conserved Domains (5) summary

smart00569
Location:30 → 83

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12037
Location:246 → 304

SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)

smart00072
Location:376 → 557

GuKc; Guanylate kinase homologues

cd00992
Location:155 → 233

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02828
Location:85 → 136

L27; L27 domain
NM_001414216.1 → NP_001401145.1 MAGUK p55 subfamily member 2 isoform 2

Status: VALIDATED

Source sequence(s)

AL591145

UniProtKB/Swiss-Prot

B1AQF8, Q3T9W1, Q3TT52, Q3URK8, Q9WV34
NM_001414217.1 → NP_001401146.1 MAGUK p55 subfamily member 2 isoform 2

Status: VALIDATED

Source sequence(s)

AL591145

UniProtKB/Swiss-Prot

B1AQF8, Q3T9W1, Q3TT52, Q3URK8, Q9WV34
NM_001414218.1 → NP_001401147.1 MAGUK p55 subfamily member 2 isoform 2

Status: VALIDATED

Source sequence(s)

AL591145

UniProtKB/Swiss-Prot

B1AQF8, Q3T9W1, Q3TT52, Q3URK8, Q9WV34
NM_001414219.1 → NP_001401148.1 MAGUK p55 subfamily member 2 isoform 2

Status: VALIDATED

Source sequence(s)

AL591145

UniProtKB/Swiss-Prot

B1AQF8, Q3T9W1, Q3TT52, Q3URK8, Q9WV34
NM_001414220.1 → NP_001401149.1 MAGUK p55 subfamily member 2 isoform 3

Status: VALIDATED

Source sequence(s)

AL591145
NM_001414221.1 → NP_001401150.1 MAGUK p55 subfamily member 2 isoform 4

Status: VALIDATED

Source sequence(s)

AL591145
NM_016695.5 → NP_057904.1 MAGUK p55 subfamily member 2 isoform 2

See identical proteins and their annotated locations for NP_057904.1

Status: VALIDATED

Source sequence(s)

AL591145

Consensus CDS

CCDS25485.1

UniProtKB/Swiss-Prot

B1AQF8, Q3T9W1, Q3TT52, Q3URK8, Q9WV34

Related

ENSMUSP00000017458.4, ENSMUST00000017458.11

Conserved Domains (5) summary

smart00569
Location:13 → 66

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12037
Location:229 → 287

SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)

smart00072
Location:359 → 540

GuKc; Guanylate kinase homologues

cd00992
Location:138 → 216

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02828
Location:68 → 119

L27; L27 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

101947841..101979464 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030246119.2 → XP_030101979.1 MAGUK p55 subfamily member 2 isoform X4

Conserved Domains (3) summary

cd12037
Location:90 → 148

SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)

smart00072
Location:220 → 401

GuKc; Guanylate kinase homologues

cd00992
Location:1 → 77

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_036156826.1 → XP_036012719.1 MAGUK p55 subfamily member 2 isoform X4

Conserved Domains (3) summary

cd12037
Location:90 → 148

SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)

smart00072
Location:220 → 401

GuKc; Guanylate kinase homologues

cd00992
Location:1 → 77

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_030246120.2 → XP_030101980.1 MAGUK p55 subfamily member 2 isoform X4

Conserved Domains (3) summary

cd12037
Location:90 → 148

SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)

smart00072
Location:220 → 401

GuKc; Guanylate kinase homologues

cd00992
Location:1 → 77

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_036156825.1 → XP_036012718.1 MAGUK p55 subfamily member 2 isoform X3

Conserved Domains (5) summary

smart00569
Location:13 → 66

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12037
Location:229 → 287

SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)

smart00072
Location:359 → 496

GuKc; Guanylate kinase homologues

cd00992
Location:138 → 216

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02828
Location:68 → 119

L27; L27 domain
XM_036156827.1 → XP_036012720.1 MAGUK p55 subfamily member 2 isoform X5

Conserved Domains (3) summary

cd12037
Location:90 → 148

SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)

smart00072
Location:220 → 357

GuKc; Guanylate kinase homologues

cd00992
Location:1 → 77

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...