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    Nsrp1 nuclear speckle regulatory protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 237859, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Nsrp1provided by MGI
    Official Full Name
    nuclear speckle regulatory protein 1provided by MGI
    Primary source
    MGI:MGI:2144305
    See related
    Ensembl:ENSMUSG00000037958 AllianceGenome:MGI:2144305
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ccdc55; NSpr70; NSrp70; 8030451K07
    Summary
    Predicted to enable mRNA binding activity. Acts upstream of or within in utero embryonic development. Predicted to be located in nuclear speck. Predicted to be part of ribonucleoprotein complex. Is expressed in several structures, including compacted morula; immune system; and oocyte. Orthologous to human NSRP1 (nuclear speckle splicing regulatory protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 7.3), placenta adult (RPKM 3.5) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nsrp1 in Genome Data Viewer
    Location:
    11 B5; 11 46.21 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (76935118..76969263, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (77044292..77078437, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr11:76759053-76759354 Neighboring gene STARR-seq mESC enhancer starr_30047 Neighboring gene bleomycin hydrolase Neighboring gene solute carrier family 6 member 4 gene promoter Neighboring gene solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Neighboring gene predicted gene 12343 Neighboring gene STARR-seq mESC enhancer starr_30048 Neighboring gene STARR-seq mESC enhancer starr_30049 Neighboring gene predicted gene, 22772 Neighboring gene STARR-seq mESC enhancer starr_30050 Neighboring gene STARR-positive B cell enhancer ABC_E592 Neighboring gene microRNA 423 Neighboring gene EF-hand calcium binding domain 5 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit G1 pseudogene Neighboring gene upstream transcription factor 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NSrp70 is a lymphocyte-essential splicing factor that controls thymocyte development. Kim CH, et al. Nucleic Acids Res, 2021 Jun 4. PMID 34037780, Free PMC Article
    2. NSrp70 is a novel nuclear speckle-related protein that modulates alternative pre-mRNA splicing in vivo. Kim YD, et al. Nucleic Acids Res, 2011 May. PMID 21296756, Free PMC Article
    3. Three-dimensional molecular architecture of mouse organogenesis. Qu F, et al. Nat Commun, 2023 Jul 31. PMID 37524711, Free PMC Article
    4. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
    5. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NSrp70 is a lymphocyte-essential splicing factor that controls thymocyte development.
      Title: NSrp70 is a lymphocyte-essential splicing factor that controls thymocyte development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107323

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in developmental process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in developmental process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nuclear speckle splicing regulatory protein 1
    Names
    coiled-coil domain containing 55
    coiled-coil domain-containing protein 55
    nuclear speckle-related protein 70

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012309.2 → NP_001012309.1  nuclear speckle splicing regulatory protein 1

      Status: VALIDATED

      Source sequence(s)
      AK078762, AK161058, AL603842, BF462050
      Consensus CDS
      CCDS25075.1
      UniProtKB/Swiss-Prot
      Q5NCR9
      Related
      ENSMUSP00000099552.2, ENSMUST00000102494.8
      Conserved Domains (1) summary
      pfam09745
      Location:57 → 176
      DUF2040; Coiled-coil domain-containing protein 55 (DUF2040)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      76935118..76969263 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5NCR9.1 GenPept UniProtKB/Swiss-Prot:Q5NCR9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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