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    Usp43 ubiquitin specific peptidase 43 [ Mus musculus (house mouse) ]

    Gene ID: 216835, updated on 27-Nov-2024

    Summary

    Official Symbol
    Usp43provided by MGI
    Official Full Name
    ubiquitin specific peptidase 43provided by MGI
    Primary source
    MGI:MGI:2444541
    See related
    Ensembl:ENSMUSG00000020905 AllianceGenome:MGI:2444541
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in protein deubiquitination and proteolysis. Orthologous to human USP43 (ubiquitin specific peptidase 43). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in colon adult (RPKM 9.8), large intestine adult (RPKM 7.0) and 17 other tissues See more
    Orthologs
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    Genomic context

    See Usp43 in Genome Data Viewer
    Location:
    11 B3; 11 41.13 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (67745349..67812979, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (67854523..67922153, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene dehydrogenase/reductase 7C Neighboring gene predicted gene, 40032 Neighboring gene cilia and flagella associated protein 52 Neighboring gene syntaxin 8 Neighboring gene ribosomal protein L31 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

    General gene information

    Clone Names

    • 9130017K11Rik, C630032K07Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 43
    Names
    deubiquitinating enzyme 43
    ubiquitin thioesterase 43
    ubiquitin thiolesterase 43
    ubiquitin-specific-processing protease 43
    NP_001277978.1
    NP_776115.2
    XP_011247217.1
    XP_017169942.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291049.1NP_001277978.1  ubiquitin carboxyl-terminal hydrolase 43 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AK042217, AK083271, AL732570
      Consensus CDS
      CCDS70212.1
      UniProtKB/TrEMBL
      A6PWR8
      Related
      ENSMUSP00000104317.2, ENSMUST00000108677.2
      Conserved Domains (2) summary
      cd02674
      Location:536703
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:102284
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    2. NM_173754.4NP_776115.2  ubiquitin carboxyl-terminal hydrolase 43 isoform 1

      See identical proteins and their annotated locations for NP_776115.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK042217, AK083271, AL732570
      Consensus CDS
      CCDS24861.2
      UniProtKB/Swiss-Prot
      Q8BUM9, Q8VDP5
      Related
      ENSMUSP00000021288.4, ENSMUST00000021288.10
      Conserved Domains (2) summary
      cd02674
      Location:536708
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:102284
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      67745349..67812979 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248915.4XP_011247217.1  ubiquitin carboxyl-terminal hydrolase 43 isoform X1

      Conserved Domains (1) summary
      cd02674
      Location:225397
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    2. XM_017314453.2XP_017169942.1  ubiquitin carboxyl-terminal hydrolase 43 isoform X2

      Conserved Domains (1) summary
      cd02674
      Location:93265
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...