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    Tbrg4 transforming growth factor beta regulated gene 4 [ Mus musculus (house mouse) ]

    Gene ID: 21379, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tbrg4provided by MGI
    Official Full Name
    transforming growth factor beta regulated gene 4provided by MGI
    Primary source
    MGI:MGI:1100868
    See related
    Ensembl:ENSMUSG00000000384 AllianceGenome:MGI:1100868
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cpr2; Tb-12; 2310042P22Rik
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in mitochondrial mRNA processing and regulation of mitochondrial mRNA stability. Located in mitochondrion. Is expressed in axial musculature; germ cell of testis; ovary; and seminiferous cord. Orthologous to human TBRG4 (transforming growth factor beta regulator 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 29.8), large intestine adult (RPKM 26.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tbrg4 in Genome Data Viewer
    Location:
    11 A1; 11 4.6 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (6565598..6576089, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (6615598..6626084, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene cerebral cavernous malformation 2 Neighboring gene STARR-positive B cell enhancer mm9_chr11:6481502-6481803 Neighboring gene NAC alpha domain containing Neighboring gene predicted gene, 24313 Neighboring gene small nucleolar RNA, H/ACA box 5C Neighboring gene whey acidic protein Neighboring gene predicted gene 11978 Neighboring gene receptor (calcitonin) activity modifying protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Single-cell transcriptomics reveal temporal dynamics of critical regulators of germ cell fate during mouse sex determination. Mayère C, et al. FASEB J, 2021 Apr. PMID 33749946
    2. Epigenetic modifications and chromatin loop organization explain the different expression profiles of the Tbrg4, WAP and Ramp3 genes. Montazer-Torbati MB, et al. Exp Cell Res, 2008 Mar 10. PMID 18255060
    3. Modulation of gene expression in the preimplantation mouse embryo by TGF-alpha and TGF-beta. Babalola GO, et al. Mol Reprod Dev, 1995 Jun. PMID 7654366
    4. Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration. Simarro M, et al. Biochem Biophys Res Commun, 2010 Oct 22. PMID 20869947, Free PMC Article
    5. Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Chu CC, et al. Mol Immunol, 1998 Jun. PMID 9798653

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. tight regulation of WAP gene expression parallels variations in the chromatin structure and DNA methylation profile throughout the Ramp3-WAP-Tbrg4 locus.
      Title: Epigenetic modifications and chromatin loop organization explain the different expression profiles of the Tbrg4, WAP and Ramp3 genes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • mKIAA0948

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial mRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial mRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of mitochondrial mRNA stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitochondrial mRNA stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitochondrial mRNA stability ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    FAST kinase domain-containing protein 4
    Names
    cell cycle progression 2 protein
    protein TBRG4
    transforming growth factor beta regulator 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130457.2 → NP_001123929.1  FAST kinase domain-containing protein 4 isoform 1

      See identical proteins and their annotated locations for NP_001123929.1

      Status: VALIDATED

      Source sequence(s)
      BC031910, BY784127
      Consensus CDS
      CCDS24423.1
      UniProtKB/Swiss-Prot
      O89082, Q3TKZ4, Q6ZQ19, Q8C6D1, Q91YM4
      Related
      ENSMUSP00000140835.2, ENSMUST00000189268.7
      Conserved Domains (3) summary
      smart00952
      Location:562 → 619
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:368 → 437
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:453 → 534
      FAST_2; FAST kinase-like protein, subdomain 2

    2. NM_001362713.1 → NP_001349642.1  FAST kinase domain-containing protein 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL603787
      Consensus CDS
      CCDS24423.1
      UniProtKB/Swiss-Prot
      O89082, Q3TKZ4, Q6ZQ19, Q8C6D1, Q91YM4
      Conserved Domains (3) summary
      smart00952
      Location:562 → 619
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:368 → 437
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:453 → 534
      FAST_2; FAST kinase-like protein, subdomain 2

    3. NM_001362714.1 → NP_001349643.1  FAST kinase domain-containing protein 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL603787
      Consensus CDS
      CCDS24423.1
      UniProtKB/Swiss-Prot
      O89082, Q3TKZ4, Q6ZQ19, Q8C6D1, Q91YM4
      Conserved Domains (3) summary
      smart00952
      Location:562 → 619
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:368 → 437
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:453 → 534
      FAST_2; FAST kinase-like protein, subdomain 2

    4. NM_001362715.1 → NP_001349644.1  FAST kinase domain-containing protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL603787
      Conserved Domains (3) summary
      smart00952
      Location:275 → 332
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:81 → 150
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:166 → 247
      FAST_2; FAST kinase-like protein, subdomain 2

    5. NM_001362716.1 → NP_001349645.1  FAST kinase domain-containing protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL603787
      Conserved Domains (3) summary
      smart00952
      Location:275 → 332
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:81 → 150
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:166 → 247
      FAST_2; FAST kinase-like protein, subdomain 2

    6. NM_134011.3 → NP_598772.1  FAST kinase domain-containing protein 4 isoform 1

      See identical proteins and their annotated locations for NP_598772.1

      Status: VALIDATED

      Source sequence(s)
      AK144813, BB727683, BC031910, BY784127
      Consensus CDS
      CCDS24423.1
      UniProtKB/Swiss-Prot
      O89082, Q3TKZ4, Q6ZQ19, Q8C6D1, Q91YM4
      Related
      ENSMUSP00000000394.8, ENSMUST00000000394.14
      Conserved Domains (3) summary
      smart00952
      Location:562 → 619
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:368 → 437
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:453 → 534
      FAST_2; FAST kinase-like protein, subdomain 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      6565598..6576089 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514607.5 → XP_006514670.1  FAST kinase domain-containing protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006514670.1

      UniProtKB/Swiss-Prot
      O89082, Q3TKZ4, Q6ZQ19, Q8C6D1, Q91YM4
      Conserved Domains (3) summary
      smart00952
      Location:562 → 619
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:368 → 437
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:453 → 534
      FAST_2; FAST kinase-like protein, subdomain 2

    2. XM_011243672.3 → XP_011241974.1  FAST kinase domain-containing protein 4 isoform X2

      Conserved Domains (3) summary
      smart00952
      Location:275 → 332
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:81 → 150
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:166 → 247
      FAST_2; FAST kinase-like protein, subdomain 2

    RNA

    1. XR_001779944.2 RNA Sequence

      Related
      ENSMUST00000150697.8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91YM4.1 GenPept UniProtKB/Swiss-Prot:Q91YM4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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