Card14 caspase recruitment domain family, member 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Card14provided by MGI
Official Full Name: caspase recruitment domain family, member 14provided by MGI
Primary source: MGI:MGI:2386258
See related: Ensembl:ENSMUSG00000013483 AllianceGenome:MGI:2386258
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bimp2; CARMA2
Summary: Predicted to enable CARD domain binding activity. Predicted to be involved in several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of canonical NF-kappaB signal transduction; and tumor necrosis factor-mediated signaling pathway. Predicted to be located in aggresome and cytosol. Is expressed in gut; nose; and vibrissa. Used to study psoriasis 2. Human ortholog(s) of this gene implicated in pityriasis rubra pilaris and psoriasis 2. Orthologous to human CARD14 (caspase recruitment domain family member 14). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in colon adult (RPKM 7.9), large intestine adult (RPKM 5.4) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 83.36 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (119197923..119236205)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (119307093..119345379)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CARD14 signalosome formation is associated with its endosomal relocation and mTORC1-induced keratinocyte proliferation.
Title: CARD14 signalosome formation is associated with its endosomal relocation and mTORC1-induced keratinocyte proliferation.
CARD14(E138A) signalling in keratinocytes induces TNF-dependent skin and systemic inflammation.
Title: CARD14(E138A) signalling in keratinocytes induces TNF-dependent skin and systemic inflammation.
hyperactivation of CARD14 alone is sufficient to orchestrate the complex immunopathogenesis that drives T helper type 17-mediated psoriasis skin disease in vivo.
Title: CARD14 Gain-of-Function Mutation Alone Is Sufficient to Drive IL-23/IL-17-Mediated Psoriasiform Skin Inflammation In Vivo.
Caspase recruitment domain family member 14 (Card14)(E138A/+) and Card14(DeltaQ136/+) mice develop spontaneous psoriasis-like skin inflammation, resulted from constitutively activated CARMA2 via self-aggregation leading to the enhanced activation of the IL-23-IL-17A cytokine axis. Card14(-/-) mice display attenuated skin inflammation in the imiquimod-induced psoriasis model due to impaired IL-17A signaling in keratinoc...
Title: Gain-of-Function Mutation of Card14 Leads to Spontaneous Psoriasis-like Skin Inflammation through Enhanced Keratinocyte Response to IL-17A.
in experimental models of psoriasis induced by either imiquimod cream or recombinant IL-23 injection, the psoriasiform skin inflammation was abrogated in Card14(-/-) mice
Title: Essential Role of CARD14 in Murine Experimental Psoriasis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (9) 1 citation
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables CARD domain binding	IEA Inferred from Electronic Annotation more info
enables CARD domain binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in tumor necrosis factor-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in aggresome	IEA Inferred from Electronic Annotation more info
located_in aggresome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: caspase recruitment domain-containing protein 14

Names: bcl10-interacting MAGUK protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130886.4 → NP_570956.1 caspase recruitment domain-containing protein 14

See identical proteins and their annotated locations for NP_570956.1

Status: VALIDATED

Source sequence(s)

AL645911

Consensus CDS

CCDS25715.1

UniProtKB/Swiss-Prot

Q99KF0

Related

ENSMUSP00000101857.2, ENSMUST00000106250.8

Conserved Domains (8) summary

cd00992
Location:580 → 652

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00261
Location:120 → 364

Tropomyosin; Tropomyosin

pfam15898
Location:205 → 275

PRKG1_interact; cGMP-dependent protein kinase interacting domain

cd16269
Location:374 → 385

GBP_C; coiled coil [structural motif]

cl14633
Location:19 → 104

DD; Death Domain Superfamily of protein-protein interaction domains

cl17036
Location:677 → 738

SH3; Src Homology 3 domain superfamily

cl17190
Location:854 → 978

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

cl20817
Location:282 → 407

GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

119197923..119236205

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532369.4 → XP_006532432.1 caspase recruitment domain-containing protein 14 isoform X1

See identical proteins and their annotated locations for XP_006532432.1

Conserved Domains (5) summary

COG1196
Location:132 → 410

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00992
Location:587 → 659

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl14633
Location:19 → 104

DD; Death Domain Superfamily of protein-protein interaction domains

cl17036
Location:684 → 745

SH3; Src Homology 3 domain superfamily

cl17190
Location:884 → 1008

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_006532379.5 → XP_006532442.1 caspase recruitment domain-containing protein 14 isoform X6

Conserved Domains (4) summary

COG1196
Location:132 → 410

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00992
Location:587 → 659

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl14633
Location:19 → 104

DD; Death Domain Superfamily of protein-protein interaction domains

cl17036
Location:684 → 745

SH3; Src Homology 3 domain superfamily
XM_006532378.5 → XP_006532441.1 caspase recruitment domain-containing protein 14 isoform X5

Conserved Domains (4) summary

COG1196
Location:132 → 410

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00992
Location:587 → 659

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl14633
Location:19 → 104

DD; Death Domain Superfamily of protein-protein interaction domains

cl17036
Location:684 → 745

SH3; Src Homology 3 domain superfamily
XM_006532371.5 → XP_006532434.1 caspase recruitment domain-containing protein 14 isoform X1

See identical proteins and their annotated locations for XP_006532434.1

Conserved Domains (5) summary

COG1196
Location:132 → 410

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00992
Location:587 → 659

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl14633
Location:19 → 104

DD; Death Domain Superfamily of protein-protein interaction domains

cl17036
Location:684 → 745

SH3; Src Homology 3 domain superfamily

cl17190
Location:884 → 1008

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_006532366.4 → XP_006532429.1 caspase recruitment domain-containing protein 14 isoform X1

See identical proteins and their annotated locations for XP_006532429.1

Conserved Domains (5) summary

COG1196
Location:132 → 410

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00992
Location:587 → 659

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl14633
Location:19 → 104

DD; Death Domain Superfamily of protein-protein interaction domains

cl17036
Location:684 → 745

SH3; Src Homology 3 domain superfamily

cl17190
Location:884 → 1008

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_006532373.3 → XP_006532436.1 caspase recruitment domain-containing protein 14 isoform X2

Conserved Domains (5) summary

COG1196
Location:132 → 410

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00992
Location:580 → 652

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl14633
Location:19 → 104

DD; Death Domain Superfamily of protein-protein interaction domains

cl17036
Location:677 → 738

SH3; Src Homology 3 domain superfamily

cl17190
Location:877 → 1001

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_006532374.4 → XP_006532437.1 caspase recruitment domain-containing protein 14 isoform X3

Conserved Domains (5) summary

COG1196
Location:132 → 410

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00992
Location:579 → 651

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl14633
Location:19 → 104

DD; Death Domain Superfamily of protein-protein interaction domains

cl17036
Location:676 → 737

SH3; Src Homology 3 domain superfamily

cl17190
Location:876 → 1000

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_006532370.5 → XP_006532433.1 caspase recruitment domain-containing protein 14 isoform X1

See identical proteins and their annotated locations for XP_006532433.1

Conserved Domains (5) summary

COG1196
Location:132 → 410

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00992
Location:587 → 659

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl14633
Location:19 → 104

DD; Death Domain Superfamily of protein-protein interaction domains

cl17036
Location:684 → 745

SH3; Src Homology 3 domain superfamily

cl17190
Location:884 → 1008

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_006532372.5 → XP_006532435.1 caspase recruitment domain-containing protein 14 isoform X1

See identical proteins and their annotated locations for XP_006532435.1

Conserved Domains (5) summary

COG1196
Location:132 → 410

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00992
Location:587 → 659

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl14633
Location:19 → 104

DD; Death Domain Superfamily of protein-protein interaction domains

cl17036
Location:684 → 745

SH3; Src Homology 3 domain superfamily

cl17190
Location:884 → 1008

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_006532367.5 → XP_006532430.1 caspase recruitment domain-containing protein 14 isoform X1

See identical proteins and their annotated locations for XP_006532430.1

Conserved Domains (5) summary

COG1196
Location:132 → 410

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00992
Location:587 → 659

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl14633
Location:19 → 104

DD; Death Domain Superfamily of protein-protein interaction domains

cl17036
Location:684 → 745

SH3; Src Homology 3 domain superfamily

cl17190
Location:884 → 1008

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_006532375.3 → XP_006532438.1 caspase recruitment domain-containing protein 14 isoform X4

Conserved Domains (5) summary

COG1196
Location:132 → 410

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00992
Location:587 → 659

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl14633
Location:19 → 104

DD; Death Domain Superfamily of protein-protein interaction domains

cl17036
Location:684 → 745

SH3; Src Homology 3 domain superfamily

cl17190
Location:861 → 985

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_006532368.5 → XP_006532431.1 caspase recruitment domain-containing protein 14 isoform X1

See identical proteins and their annotated locations for XP_006532431.1

Conserved Domains (5) summary

COG1196
Location:132 → 410

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00992
Location:587 → 659

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl14633
Location:19 → 104

DD; Death Domain Superfamily of protein-protein interaction domains

cl17036
Location:684 → 745

SH3; Src Homology 3 domain superfamily

cl17190
Location:884 → 1008

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...