Lrrc75b leucine rich repeat containing 75B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lrrc75bprovided by MGI
Official Full Name: leucine rich repeat containing 75Bprovided by MGI
Primary source: MGI:MGI:2143657
See related: Ensembl:ENSMUSG00000046807 AllianceGenome:MGI:2143657
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fam211b
Summary: Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human LRRC75B (leucine rich repeat containing 75B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E18 (RPKM 8.1), whole brain E14.5 (RPKM 7.6) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 38.55 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (75385953..75396532, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (75550119..75560680, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that leucine rich repeat containing 75B (Lrrc75b) is a suppressor of C2C12 myoblast myogenic differentiation.
Title: Lrrc75b is a novel negative regulator of C2C12 myogenic differentiation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: leucine-rich repeat-containing protein 75B

Names: family with sequence similarity 211, member B; leucine-rich repeat-containing protein C22orf36 homolog; leucine-rich repeat-containing protein FAM211B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198860.2 → NP_942560.1 leucine-rich repeat-containing protein 75B

See identical proteins and their annotated locations for NP_942560.1

Status: VALIDATED

Source sequence(s)

AK132309, BC056492

Consensus CDS

CCDS35937.1

UniProtKB/Swiss-Prot

Q3V1Q4, Q7TPD7

Related

ENSMUSP00000053085.10, ENSMUST00000051129.10

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

75385953..75396532 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155705.1 → XP_036011598.1 leucine-rich repeat-containing protein 75B isoform X1

Conserved Domains (1) summary

cl39015
Location:15 → 92

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...