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    Ifi203 interferon activated gene 203 [ Mus musculus (house mouse) ]

    Gene ID: 15950, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ifi203provided by MGI
    Official Full Name
    interferon activated gene 203provided by MGI
    Primary source
    MGI:MGI:96428
    See related
    Ensembl:ENSMUSG00000039997 AllianceGenome:MGI:96428
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mndal; Ifi203a; Ifi203b
    Summary
    Predicted to enable double-stranded DNA binding activity and identical protein binding activity. Acts upstream of or within cellular response to interferon-beta. Predicted to be located in nucleolus. Predicted to be active in cytosol and nucleoplasm. Orthologous to human IFI16 (interferon gamma inducible protein 16). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in spleen adult (RPKM 5.0), mammary gland adult (RPKM 4.3) and 18 other tissues See more
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    Genomic context

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    See Ifi203 in Genome Data Viewer
    Location:
    1 H3; 1 80.76 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (173747966..173770432, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (173920400..173942866, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 21031 Neighboring gene interferon activated gene 211 Neighboring gene STARR-positive B cell enhancer ABC_E11108 Neighboring gene STARR-positive B cell enhancer ABC_E3335 Neighboring gene STARR-positive B cell enhancer ABC_E11109 Neighboring gene interferon activated gene 202B Neighboring gene interferon activated gene 204 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Interferons as gene activators: close linkage of two interferon-activatable murine genes. Engel DA, et al. Virology, 1988 Sep. PMID 2457983
    2. Multiple splicing results in at least two p203 proteins that are expressed in the liver and down-regulated during liver regeneration. Zhang Y, et al. Front Biosci, 2008 Jan 1. PMID 17981725
    3. Molecular cloning and expression of an interferon-inducible protein encoded by gene 203 from the gene 200 cluster. Gribaudo G, et al. Eur J Biochem, 1997 Oct 1. PMID 9363777
    4. In vitro and in vivo expression analysis of the interferon-inducible 203 gene. Gribaudo G, et al. J Interferon Cytokine Res, 1999 Feb. PMID 10090398
    5. Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis. Norheim F, et al. Mol Syst Biol, 2021 Jan. PMID 33417276, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis.
      Title: Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis.
    2. analysis of p203 proteins that are expressed in the liver and down-regulated during liver regeneration
      Title: Multiple splicing results in at least two p203 proteins that are expressed in the liver and down-regulated during liver regeneration.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in activation of innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in activation of innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in activation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to glucose starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to interferon-beta IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cellular response to interferon-beta IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of AIM2 inflammasome complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression, epigenetic ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    interferon-activable protein 203
    Names
    interferon-inducible protein p203

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302649.1 → NP_001289578.1  interferon-activable protein 203 isoform 1

      See identical proteins and their annotated locations for NP_001289578.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC170584, AK040214, AK137616, AK144663, BE691222
      Consensus CDS
      CCDS78754.1
      UniProtKB/TrEMBL
      A0A1Z3MHZ5, E9QAN9
      Related
      ENSMUSP00000122424.2, ENSMUST00000129829.8
      Conserved Domains (2) summary
      cd08305
      Location:10 → 83
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:665 → 831
      HIN; HIN-200/IF120x domain

    2. NM_001302650.1 → NP_001289579.1  interferon-activable protein 203 isoform 2

      See identical proteins and their annotated locations for NP_001289579.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an in-frame exon in the coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AK144663, BE691222
      Consensus CDS
      CCDS48453.1
      UniProtKB/Swiss-Prot
      O35368, Q3T9I1, Q3TEA2, Q3TP57, Q3UMV2, Q8BYE5, Q91VV8
      UniProtKB/TrEMBL
      A0A0R4J0H6
      Related
      ENSMUSP00000114221.2, ENSMUST00000156895.8
      Conserved Domains (2) summary
      cd08305
      Location:10 → 83
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:251 → 417
      HIN; HIN-200/IF120x domain

    3. NM_001302651.1 → NP_001289580.1  interferon-activable protein 203 isoform 3

      See identical proteins and their annotated locations for NP_001289580.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two in-frame exons in the coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AK040214, AK144663, BE691222
      Consensus CDS
      CCDS35793.1
      UniProtKB/Swiss-Prot
      O35368, Q3T9I1, Q3TEA2, Q3TP57, Q3UMV2, Q8BYE5, Q91VV8
      UniProtKB/TrEMBL
      E9PUG6
      Related
      ENSMUSP00000121480.2, ENSMUST00000123708.8
      Conserved Domains (2) summary
      cd08305
      Location:10 → 83
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:203 → 369
      HIN; HIN-200/IF120x domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      173747966..173770432 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250226.1 → XP_030106086.1  interferon-activable protein 203 isoform X5

      Conserved Domains (1) summary
      pfam02760
      Location:377 → 543
      HIN; HIN-200/IF120x domain

    2. XM_030250260.1 → XP_030106120.1  interferon-activable protein 203 isoform X7

      UniProtKB/Swiss-Prot
      O35368, Q3T9I1, Q3TEA2, Q3TP57, Q3UMV2, Q8BYE5, Q91VV8
      UniProtKB/TrEMBL
      E9PUG6
      Conserved Domains (2) summary
      cd08305
      Location:10 → 83
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:203 → 369
      HIN; HIN-200/IF120x domain

    3. XM_011238761.4 → XP_011237063.1  interferon-activable protein 203 isoform X1

      See identical proteins and their annotated locations for XP_011237063.1

      UniProtKB/TrEMBL
      A0A1Z3MHZ5
      Conserved Domains (2) summary
      cd08305
      Location:10 → 83
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:677 → 843
      HIN; HIN-200/IF120x domain

    4. XM_011238760.3 → XP_011237062.1  interferon-activable protein 203 isoform X1

      See identical proteins and their annotated locations for XP_011237062.1

      UniProtKB/TrEMBL
      A0A1Z3MHZ5
      Conserved Domains (2) summary
      cd08305
      Location:10 → 83
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:677 → 843
      HIN; HIN-200/IF120x domain

    5. XM_036162001.1 → XP_036017894.1  interferon-activable protein 203 isoform X6

      Conserved Domains (1) summary
      pfam02760
      Location:365 → 531
      HIN; HIN-200/IF120x domain

    6. XM_006496669.4 → XP_006496732.1  interferon-activable protein 203 isoform X3

      Conserved Domains (2) summary
      cd08305
      Location:10 → 83
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:629 → 795
      HIN; HIN-200/IF120x domain

    7. XM_011238762.3 → XP_011237064.1  interferon-activable protein 203 isoform X2

      See identical proteins and their annotated locations for XP_011237064.1

      UniProtKB/TrEMBL
      A0A1Z3MHZ5, E9QAN9
      Conserved Domains (2) summary
      cd08305
      Location:10 → 83
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:665 → 831
      HIN; HIN-200/IF120x domain

    8. XM_006496671.5 → XP_006496734.1  interferon-activable protein 203 isoform X4

      Conserved Domains (1) summary
      pfam02760
      Location:485 → 651
      HIN; HIN-200/IF120x domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001045481.1: Suppressed sequence

      Description
      NM_001045481.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.

    2. NM_008328.2: Suppressed sequence

      Description
      NM_008328.2: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35368.1 GenPept UniProtKB/Swiss-Prot:O35368

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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