Rassf5 Ras association (RalGDS/AF-6) domain family member 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rassf5provided by MGI
Official Full Name: Ras association (RalGDS/AF-6) domain family member 5provided by MGI
Primary source: MGI:MGI:1926375
See related: Ensembl:ENSMUSG00000026430 AllianceGenome:MGI:1926375
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rapl; Maxp1; Nore1; Nore1A; Nore1B; 1300019G20Rik
Summary: Predicted to enable identical protein binding activity. Acts upstream of or within negative regulation of lymphocyte proliferation; positive regulation of protein ubiquitination; and regulation of protein localization to nucleus. Located in nucleus. Is expressed in heart and thymus primordium. Used to study systemic lupus erythematosus. Orthologous to human RASSF5 (Ras association domain family member 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in thymus adult (RPKM 26.1), spleen adult (RPKM 15.1) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 56.91 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (131104147..131172915, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (131176410..131245178, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nore1 inhibits age-associated myeloid lineage skewing and clonal hematopoiesis but facilitates termination of emergency (stress) granulopoiesis.
Title: Nore1 inhibits age-associated myeloid lineage skewing and clonal hematopoiesis but facilitates termination of emergency (stress) granulopoiesis.
Histone demethylase Jmjd3 modulates osteoblast apoptosis induced by tumor necrosis factor-alpha through directly targeting RASSF5.
Title: Histone demethylase Jmjd3 modulates osteoblast apoptosis induced by tumor necrosis factor-alpha through directly targeting RASSF5.
Interplay of opposing fate choices stalls oncogenic growth in murine skin epithelium.
Title: Interplay of opposing fate choices stalls oncogenic growth in murine skin epithelium.
Rassf5 and Ndr1 or Ndr2 kinases regulate neuronal polarity through Par3 phosphorylation.
Title: Rassf5 and Ndr kinases regulate neuronal polarity through Par3 phosphorylation in a novel pathway.
These findings indicate that the control of HIPK1 stability by Mdm2-NORE1 has a major effect on cell behaviour, and epigenetic inactivation of NORE1 enables adenocarcinoma formation in vivo through HIPK1 stabilization.
Title: Mdm2 associates with Ras effector NORE1 to induce the degradation of oncoprotein HIPK1.
gene deficient mice experience age-related lupus-like glomerulonephritis and develope B cell lymphomas
Title: Deficiency of Rap1-binding protein RAPL causes lymphoproliferative disorders through mislocalization of p27kip1.
a direct role for RASSF5 in death receptor ligand-mediated apoptosis and provide further evidence for RASSF5 as a tumor suppressor.
Title: Tumor suppressor ras association domain family 5 (RASSF5/NORE1) mediates death receptor ligand-induced apoptosis.
a novel regulatory network composed of the tumor suppressor NORE1A, the mitotic kinase Aurora A, the small GTPase Ras, and the microtubule cytoskeleton.
Title: Growth and tumor suppressor NORE1A is a regulatory node between Ras signaling and microtubule nucleation.
findings define a T cell receptor "inside-out" pathway via N-SKAP1-C-RapL that regulates T cell adhesion, motility, and arrest times with dendritic cells in lymph nodes.
Title: T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes.
findings reveal the several critical steps of Rap1, which are RAPL-dependent and -independent, in lymphocyte trafficking
Title: Rap1 controls lymphocyte adhesion cascade and interstitial migration within lymph nodes in RAPL-dependent and -independent manners.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Mit193 (e-PCR), detects polymorphism
- UniSTS:128531

AU042887 (e-PCR)
- UniSTS:178462

Nore1-pending (e-PCR), detects polymorphism
- UniSTS:239150

Rassf5 (e-PCR), detects polymorphism
- UniSTS:499108

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of lymphocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of lymphocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein localization to nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ras association domain-containing protein 5

Names: Rap1-binding protein; new ras effector 1; novel ras effector 1; regulator for cell adhesion and polarization enriched in lymphoid tissues

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001311094.2 → NP_001298023.1 ras association domain-containing protein 5 isoform 2

See identical proteins and their annotated locations for NP_001298023.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate first exon in place of the first two exons of variant 1, resulting in a different 5' UTR and 5' coding region. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AC109262, AK131147, AK155869, DV657256

Consensus CDS

CCDS78675.1

UniProtKB/Swiss-Prot

Q5EBH1

Related

ENSMUSP00000067011.9, ENSMUST00000068564.15

Conserved Domains (2) summary

pfam16517
Location:218 → 257

Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain

cl00155
Location:119 → 212

UBQ; Ubiquitin-like proteins
NM_001313731.1 → NP_001300660.1 ras association domain-containing protein 5 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AK005059, AK029321, DV657256

Consensus CDS

CCDS83589.1

UniProtKB/TrEMBL

D3Z6G2

Related

ENSMUSP00000108061.2, ENSMUST00000112442.2

Conserved Domains (2) summary

cl00040
Location:118 → 166

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cl00155
Location:267 → 294

UBQ; Ubiquitin-like proteins
NM_018750.4 → NP_061220.2 ras association domain-containing protein 5 isoform 1

See identical proteins and their annotated locations for NP_061220.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).

Source sequence(s)

AK005059, AK029321, DV657256

Consensus CDS

CCDS15268.1

UniProtKB/Swiss-Prot

O70407, Q5EBH1, Q6KAR0, Q8C2E8

Related

ENSMUSP00000027688.9, ENSMUST00000027688.15

Conserved Domains (3) summary

pfam00130
Location:118 → 166

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam16517
Location:366 → 405

Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain

cl00155
Location:267 → 360

UBQ; Ubiquitin-like proteins