F5 coagulation factor V [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: F5provided by MGI
Official Full Name: coagulation factor Vprovided by MGI
Primary source: MGI:MGI:88382
See related: Ensembl:ENSMUSG00000026579 AllianceGenome:MGI:88382
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cf5; Cf-5
Summary: This gene encodes a glycoprotein coagulation factor that plays a critical role in the process of blood coagulation and hemostasis. The encoded protein is activated by thrombin, to generate a heterodimer containing heavy and light chains held together by calcium ions. About half of the mice lacking the encoded protein die at an embryonic stage possible due to abnormal yolk-sac vasculature while the remaining animals succumbed to massive hemorrhage immediately after birth. A point mutation in this gene has been shown to cause disseminated intravascular thrombosis in the perinatal period, resulting in frequent deaths of newborn mice. [provided by RefSeq, Apr 2015]
Expression: Biased expression in liver adult (RPKM 34.5), liver E18 (RPKM 14.1) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H2.2; 1 71.46 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (163979396..164048539)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (164151835..164220277)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

selective expression of coagulation factor V (FV) by resident peritoneal macrophages in mice promotes bacterial clearance in the peritoneal cavity.
Title: Expression of factor V by resident macrophages boosts host defense in the peritoneal cavity.
Mice with the FVL mutation do not have increased spermatogenesis as compared to wildtype mice.
Title: Factor V Leiden is associated with increased sperm count.
Platelet-derived FV is a critical mediator of arterial thrombosis that involves platelet activation.
Title: Platelet-Derived Factor V Is a Critical Mediator of Arterial Thrombosis.
Platelet-derived FV contributes to the control of angiogenesis and is likely associated with thrombin generation in hind limb ischemia model.
Title: Platelet-derived factor V promotes angiogenesis in a mouse hind limb ischemia model.
These findings reveal a novel biological function and mechanism of the protein C pathway in which protein S and the aPC-cleaved form of fV are cofactors for anti-inflammatory cell signaling by aPC in the context of endotoxemia and infection
Title: Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice.
Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of alpha1-antitrypsin.
Title: Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of α1-antitrypsin.
The FVL mutation does not influence coagulation activation, lung inflammation or survival in lethal influenza A.
Title: Factor V Leiden mutation does not affect coagulopathy or outcome in lethal H1N1 influenza.
It suggested that there could be a combination of GLA deficiency and FVL or other thrombosis-related gene defect in patients with genetic severe early-onset thrombosis.
Title: [Synergistic effect of deficiency in thrombosis-related genes].
Data suggest that tissue factor and factor V induction by LPS may in part accelerate mesangioproliferative glomerulonephritis through activation of factor X and downstream proinflammatory and procoagulant mechanisms.
Title: Lipopolysaccharide-triggered acute aggravation of mesangioproliferative glomerulonephritis through activation of coagulation in a high IgA strain of ddY mice.
Homozygous Factor V could promote atherosclerosis and fibrin deposition in apolipoprotein E deficient mice.
Title: [Factor V Leiden mutation leads to enhanced atherosclerosis in apolipoprotein E deficient mice].

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI173222 (e-PCR)
- UniSTS:178493

F5 (e-PCR), detects polymorphism
- UniSTS:525908

PMC18721P2 (e-PCR)
- UniSTS:271722

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables copper ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in blood circulation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within blood circulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in blood coagulation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within blood coagulation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within blood coagulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to vitamin K	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in platelet alpha granule	IBA Inferred from Biological aspect of Ancestor more info
located_in platelet alpha granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: coagulation factor V

Names: activated protein C cofactor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007976.4 → NP_032002.1 coagulation factor V preproprotein

See identical proteins and their annotated locations for NP_032002.1

Status: REVIEWED

Source sequence(s)

AC105161, AC110499, AC157771

Consensus CDS

CCDS35754.1

UniProtKB/Swiss-Prot

O88783, Q3UTQ2, Q3UV80

Related

ENSMUSP00000083204.6, ENSMUST00000086040.6

Conserved Domains (5) summary

smart00231
Location:1865 → 2020

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00057
Location:2027 → 2179

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd14450
Location:347 → 526

CuRO_3_FV_like; The third cupredoxin domain of coagulation factor V and similar proteins

cd14454
Location:539 → 682

CuRO_4_FV_like; The fourth cupredoxin domain of coagulation factor V and similar proteins

cl19115
Location:1539 → 1714

Cupredoxin; Cupredoxin superfamily