Paqr7 progestin and adipoQ receptor family member VII [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Paqr7provided by MGI
Official Full Name: progestin and adipoQ receptor family member VIIprovided by MGI
Primary source: MGI:MGI:1919154
See related: Ensembl:ENSMUSG00000037348 AllianceGenome:MGI:1919154
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mPR; Mpra; PGLP; mPR alpha; 2310021M12Rik
Summary: Predicted to enable nuclear steroid receptor activity and steroid binding activity. Predicted to be involved in response to steroid hormone. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and integumental system. Orthologous to human PAQR7 (progestin and adipoQ receptor family member 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 26.7), lung adult (RPKM 26.0) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.3; 4 66.8 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (134224315..134237548)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (134496761..134510237)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Progestin and adipoQ receptor 7 (PAQR7) mediate the anti-apoptotic effect of P4 on human granulosa cells and its deficiency reduces ovarian function in female mice.
Title: Progestin and adipoQ receptor 7 (PAQR7) mediate the anti-apoptotic effect of P4 on human granulosa cells and its deficiency reduces ovarian function in female mice.
Paqr7 and Paqr8 are expressed in the midbrain ventral tegmental area of proestrous mice.
Title: Progesterone-facilitated lordosis of estradiol-primed mice is attenuated by knocking down expression of membrane progestin receptors in the midbrain.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2)

General gene information

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Markers

BB007237 (e-PCR)
- UniSTS:185604

AV001994 (e-PCR)
- UniSTS:165361

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables nuclear steroid receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables steroid binding	IBA Inferred from Biological aspect of Ancestor more info
enables steroid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in oogenesis	IEA Inferred from Electronic Annotation more info
involved_in response to steroid hormone	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: membrane progestin receptor alpha

Names: PPAR-gamma-induced liver protein; membrane progesterone P4 receptor alpha; membrane progesterone receptor alpha; progesterone and adipoQ receptor family member 7; progestin and adipoQ receptor family member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001285845.2 → NP_001272774.1 membrane progestin receptor alpha

See identical proteins and their annotated locations for NP_001272774.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. All variants (1 through 5) encode the same protein.

Source sequence(s)

AL669982

Consensus CDS

CCDS18773.1

UniProtKB/Swiss-Prot

Q3TDA0, Q80ZE4, Q8BNZ7, Q9D790

UniProtKB/TrEMBL

Q3TT73

Conserved Domains (1) summary

pfam03006
Location:65 → 289

HlyIII; Haemolysin-III related
NM_001285846.2 → NP_001272775.1 membrane progestin receptor alpha

See identical proteins and their annotated locations for NP_001272775.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants (1 through 5) encode the same protein.

Source sequence(s)

AL669982

Consensus CDS

CCDS18773.1

UniProtKB/Swiss-Prot

Q3TDA0, Q80ZE4, Q8BNZ7, Q9D790

UniProtKB/TrEMBL

Q3TT73

Conserved Domains (1) summary

pfam03006
Location:65 → 289

HlyIII; Haemolysin-III related
NM_001285847.2 → NP_001272776.1 membrane progestin receptor alpha

See identical proteins and their annotated locations for NP_001272776.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All variants (1 through 5) encode the same protein.

Source sequence(s)

AL669982

Consensus CDS

CCDS18773.1

UniProtKB/Swiss-Prot

Q3TDA0, Q80ZE4, Q8BNZ7, Q9D790

UniProtKB/TrEMBL

Q3TT73

Related

ENSMUSP00000125932.2, ENSMUST00000095074.4

Conserved Domains (1) summary

pfam03006
Location:65 → 289

HlyIII; Haemolysin-III related
NM_001285849.2 → NP_001272778.1 membrane progestin receptor alpha

See identical proteins and their annotated locations for NP_001272778.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All variants (1 through 5) encode the same protein.

Source sequence(s)

AL669982

Consensus CDS

CCDS18773.1

UniProtKB/Swiss-Prot

Q3TDA0, Q80ZE4, Q8BNZ7, Q9D790

UniProtKB/TrEMBL

Q3TT73

Conserved Domains (1) summary

pfam03006
Location:65 → 289

HlyIII; Haemolysin-III related
NM_027995.4 → NP_082271.1 membrane progestin receptor alpha

See identical proteins and their annotated locations for NP_082271.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All variants (1 through 5) encode the same protein.

Source sequence(s)

AL669982

Consensus CDS

CCDS18773.1

UniProtKB/Swiss-Prot

Q3TDA0, Q80ZE4, Q8BNZ7, Q9D790

UniProtKB/TrEMBL

Q3TT73

Related

ENSMUSP00000080240.4, ENSMUST00000081525.4

Conserved Domains (1) summary

pfam03006
Location:65 → 289

HlyIII; Haemolysin-III related

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

134224315..134237548

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036164451.1 → XP_036020344.1 membrane progestin receptor alpha isoform X1

UniProtKB/Swiss-Prot

Q3TDA0, Q80ZE4, Q8BNZ7, Q9D790

UniProtKB/TrEMBL

Q3TT73

Conserved Domains (1) summary

pfam03006
Location:65 → 289

HlyIII; Haemolysin-III related