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    Kcna7 potassium voltage-gated channel, shaker-related subfamily, member 7 [ Mus musculus (house mouse) ]

    Gene ID: 16495, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kcna7provided by MGI
    Official Full Name
    potassium voltage-gated channel, shaker-related subfamily, member 7provided by MGI
    Primary source
    MGI:MGI:96664
    See related
    Ensembl:ENSMUSG00000038201 AllianceGenome:MGI:96664
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kv1.7
    Summary
    Enables voltage-gated potassium channel activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Is expressed in heart and heart ventricle. Orthologous to human KCNA7 (potassium voltage-gated channel subfamily A member 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in mammary gland adult (RPKM 6.7), heart adult (RPKM 2.7) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kcna7 in Genome Data Viewer
    Location:
    7 B3; 7 29.3 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45055384..45060806)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45405960..45411382)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11352 Neighboring gene metastasis associated gene 2 Neighboring gene lin-7 homolog B, crumbs cell polarity complex component Neighboring gene small nuclear ribonucleoprotein 70 (U1) Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52651210-52651456 Neighboring gene neurotrophin 5 Neighboring gene stabilizer of axonemal microtubules 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular and Functional Differences between Heart mKv1.7 Channel Isoforms. Finol-Urdaneta RK, et al. J Gen Physiol, 2006 Jul. PMID 16801386, Free PMC Article
    2. Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI). Bardien-Kruger S, et al. Eur J Hum Genet, 2002 Jan. PMID 11896454
    3. Initial isolation and analysis of the human Kv1.7 (KCNA7) gene, a member of the voltage-gated potassium channel gene family. Kashuba VI, et al. Gene, 2001 May 2. PMID 11368907
    4. Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7. Kalman K, et al. J Biol Chem, 1998 Mar 6. PMID 9488722
    5. Voltage-gated potassium channel genes are clustered in paralogous regions of the mouse genome. Lock LF, et al. Genomics, 1994 Apr. PMID 8034307

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables delayed rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    potassium voltage-gated channel subfamily A member 7
    Names
    potassium voltage-gated channel, shaker-related subfamily, member 7; potassium voltage gated channel, shaker related subfamily, member 7
    voltage-gated potassium channel subunit Kv1.7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010596.2 → NP_034726.2  potassium voltage-gated channel subfamily A member 7

      See identical proteins and their annotated locations for NP_034726.2

      Status: VALIDATED

      Source sequence(s)
      AC151602
      Consensus CDS
      CCDS39951.1
      UniProtKB/Swiss-Prot
      O70259, Q17ST2
      Related
      ENSMUSP00000103403.2, ENSMUST00000107774.3
      Conserved Domains (4) summary
      smart00225
      Location:47 → 130
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:228 → 437
      Ion_trans; Ion transport protein
      pfam02214
      Location:47 → 137
      BTB_2; BTB/POZ domain
      pfam07885
      Location:352 → 431
      Ion_trans_2; Ion channel

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      45055384..45060806
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q17ST2.2 GenPept UniProtKB/Swiss-Prot:Q17ST2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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