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    MORC4 MORC family CW-type zinc finger 4 [ Homo sapiens (human) ]

    Gene ID: 79710, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MORC4provided by HGNC
    Official Full Name
    MORC family CW-type zinc finger 4provided by HGNC
    Primary source
    HGNC:HGNC:23485
    See related
    Ensembl:ENSG00000133131 MIM:300970; AllianceGenome:HGNC:23485
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZCW4; ZCWCC2; dJ75H8.2
    Summary
    In human, the four current members of the microrchidia (morc) gene family share an N-terminal ATPase-like ATP-binding region and a CW four-cysteine zinc-finger motif. The protein encoded by this gene also has a nuclear matrix binding domain and a two-stranded coiled-coil motif near its C-terminus. This gene is widely expressed at low levels in normal tissues and has elevated expression in placenta and testis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jan 2010]
    Expression
    Broad expression in placenta (RPKM 38.5), adrenal (RPKM 15.2) and 18 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MORC4 in Genome Data Viewer
    Location:
    Xq22.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (106940738..107000212, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (105377254..105436736, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (106183968..106243442, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene TBC1 domain family member 8B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29830 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:106137885-106138409 Neighboring gene ripply transcriptional repressor 1 Neighboring gene claudin 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:106176295-106176796 Neighboring gene Sharpr-MPRA regulatory region 10711 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:106209370-106209870 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20925 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20926 Neighboring gene NANOG hESC enhancer GRCh37_chrX:106261730-106262231 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 40 Neighboring gene RNA binding motif protein 41 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29831 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29832

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. MORC4, a novel member of the MORC family, is highly expressed in a subset of diffuse large B-cell lymphomas. Liggins AP, et al. Br J Haematol, 2007 Aug. PMID 17608765
    2. Do pancreatic cancer and chronic pancreatitis share the same genetic risk factors? A PANcreatic Disease ReseArch (PANDoRA) consortium investigation. Campa D, et al. Int J Cancer, 2018 Jan 15. PMID 28913878
    3. Common Variants in CLDN2 and MORC4 Genes Confer Disease Susceptibility in Patients with Chronic Pancreatitis. Giri AK, et al. PLoS One, 2016. PMID 26820620, Free PMC Article
    4. MORC4 is a novel breast cancer oncogene regulated by miR-193b-3p. Yang Z, et al. J Cell Biochem, 2019 Mar. PMID 30320920
    5. Analysis of single nucleotide polymorphisms in the region of CLDN2-MORC4 in relation to inflammatory bowel disease. Söderman J, et al. World J Gastroenterol, 2013 Aug 14. PMID 23946598, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MORC4 plays a tumor-promoting role in colorectal cancer via regulating PCGF1/CDKN1A axis in vitro and in vivo.
      Title: MORC4 plays a tumor-promoting role in colorectal cancer via regulating PCGF1/CDKN1A axis in vitro and in vivo.
    2. These results identified MORC4 as differentially expressed in breast cancer cells and tissues and its downregulation by miR-193b-3p, as well as its roles in regulating the growth of breast cancer cells via regulation of apoptosis.
      Title: MORC4 is a novel breast cancer oncogene regulated by miR-193b-3p.
    3. SNP in the MORC4-rs 12837024 is associated with Chronic pancreatitis.
      Title: Do pancreatic cancer and chronic pancreatitis share the same genetic risk factors? A PANcreatic Disease ReseArch (PANDoRA) consortium investigation.
    4. Genetic variation in MORC4, CD14, and TLR4 may affect the outcome of allogeneic stem cell transplantation.
      Title: Single Nucleotide Polymorphisms in MORC4, CD14, and TLR4 Are Related to Outcome of Allogeneic Stem Cell Transplantation.
    5. Genetic variants in CLDN2 and MORC4 genes were associated with chronic pancreatitis in Indian patients.
      Title: Common Variants in CLDN2 and MORC4 Genes Confer Disease Susceptibility in Patients with Chronic Pancreatitis.
    6. Single nucleotide polymorphism is a risk factor developing chronic alcoholic pancreatitis.
      Title: Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study.
    7. Findings suggest that a variant of the CLDN2-MORC4 region predisposes to Crohn's disease in a Swedish population.
      Title: Analysis of single nucleotide polymorphisms in the region of CLDN2-MORC4 in relation to inflammatory bowel disease.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ11565

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    MORC family CW-type zinc finger protein 4
    Names
    zinc finger CW-type coiled-coil domain protein 2
    zinc finger CW-type domain protein 4
    zinc finger, CW type with coiled-coil domain 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016392.1 RefSeqGene

      Range
      5033..64507
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001085354.3 → NP_001078823.1  MORC family CW-type zinc finger protein 4 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction in the CDS compared to variant 1, that causes a frameshift. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AK300305, BQ101064, CA448781, CB989767, EF125209
      Consensus CDS
      CCDS48146.1
      UniProtKB/TrEMBL
      B4DTP6
      Related
      ENSP00000255495.7, ENST00000255495.7
      Conserved Domains (3) summary
      pfam06625
      Location:762 → 814
      DUF1151; Protein of unknown function (DUF1151)
      pfam07496
      Location:425 → 469
      zf-CW; CW-type Zinc Finger
      cl00075
      Location:50 → 170
      HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins

    2. NM_024657.5 → NP_078933.3  MORC family CW-type zinc finger protein 4 isoform a

      See identical proteins and their annotated locations for NP_078933.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK300305, BQ101064, CA448781, CB989767, EF125209
      Consensus CDS
      CCDS14525.2
      UniProtKB/Swiss-Prot
      A1YR23, A1YR24, H7BXF1, Q5JUK7, Q8TE76, Q96MZ2, Q9HAI7
      UniProtKB/TrEMBL
      B4DTP6
      Related
      ENSP00000347821.4, ENST00000355610.9
      Conserved Domains (3) summary
      pfam06625
      Location:762 → 814
      DUF1151; Protein of unknown function (DUF1151)
      pfam07496
      Location:425 → 469
      zf-CW; CW-type Zinc Finger
      cl00075
      Location:50 → 170
      HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      106940738..107000212 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      105377254..105436736 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TE76.2 GenPept UniProtKB/Swiss-Prot:Q8TE76

    Gene LinkOut

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