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    CCDC150 coiled-coil domain containing 150 [ Homo sapiens (human) ]

    Gene ID: 284992, updated on 3-Dec-2024

    Summary

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    Official Symbol
    CCDC150provided by HGNC
    Official Full Name
    coiled-coil domain containing 150provided by HGNC
    Primary source
    HGNC:HGNC:26834
    See related
    Ensembl:ENSG00000144395 AllianceGenome:HGNC:26834
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Biased expression in testis (RPKM 4.2), bone marrow (RPKM 0.6) and 6 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CCDC150 in Genome Data Viewer
    Location:
    2q33.1
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (196639715..196732806)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (197123662..197216860)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (197504439..197597525)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 Neighboring gene uncharacterized LOC105373821 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16909 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12204 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12205 Neighboring gene uncharacterized LOC105373823 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16910 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16911 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:197504225-197504762 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:197504763-197505300 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:197517516-197518164 Neighboring gene small Cajal body-specific RNA 16 Neighboring gene uncharacterized LOC100130452 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16912 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16914 Neighboring gene general transcription factor IIIC subunit 3 Neighboring gene chromosome 2 open reading frame 66

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Comprehensive Proteomic Analysis of PGC7-Interacting Proteins. Liu H, et al. J Proteome Res, 2017 Sep 1. PMID 28712289
    2. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Boldt K, et al. Nat Commun, 2016 May 13. PMID 27173435, Free PMC Article
    3. In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker. Gao H, et al. Anal Chem, 2022 May 31. PMID 35575683
    4. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. Capalbo L, et al. Nat Commun, 2019 Oct 4. PMID 31586073, Free PMC Article
    5. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10202, FLJ38811, FLJ39660, MGC72171, DKFZp434P055

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 150

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080539.2 → NP_001074008.1  coiled-coil domain-containing protein 150 isoform 1

      See identical proteins and their annotated locations for NP_001074008.1

      Status: VALIDATED

      Source sequence(s)
      AC068544
      Consensus CDS
      CCDS46478.1
      UniProtKB/Swiss-Prot
      Q6P5U6, Q6P663, Q8N8V5, Q8NCX0
      Related
      ENSP00000373827.4, ENST00000389175.9
      Conserved Domains (2) summary
      COG1196
      Location:192 → 929
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl19219
      Location:412 → 507
      DUF342; Protein of unknown function (DUF342)

    2. NM_001353339.2 → NP_001340268.1  coiled-coil domain-containing protein 150 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC068544, AK096979, AK302685
      UniProtKB/TrEMBL
      B4DZ03
      Conserved Domains (1) summary
      cl25732
      Location:2 → 678
      SMC_N; RecF/RecN/SMC N terminal domain

    3. NM_001353340.2 → NP_001340269.2  coiled-coil domain-containing protein 150 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC068544
      UniProtKB/TrEMBL
      B8ZZI4
      Related
      ENSP00000387257.1, ENST00000409270.5

    4. NM_001412753.1 → NP_001399682.1  coiled-coil domain-containing protein 150 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC068544

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      196639715..196732806
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006712438.4 → XP_006712501.1  coiled-coil domain-containing protein 150 isoform X1

      Conserved Domains (2) summary
      TIGR02168
      Location:328 → 1010
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl19219
      Location:412 → 507
      DUF342; Protein of unknown function (DUF342)

    2. XM_017003863.2 → XP_016859352.1  coiled-coil domain-containing protein 150 isoform X3

    3. XM_047443975.1 → XP_047299931.1  coiled-coil domain-containing protein 150 isoform X4

    4. XM_017003861.2 → XP_016859350.1  coiled-coil domain-containing protein 150 isoform X2

    5. XM_047443976.1 → XP_047299932.1  coiled-coil domain-containing protein 150 isoform X5

    6. XM_047443977.1 → XP_047299933.1  coiled-coil domain-containing protein 150 isoform X6

    7. XM_017003864.2 → XP_016859353.1  coiled-coil domain-containing protein 150 isoform X7

      Conserved Domains (1) summary
      TIGR02168
      Location:136 → 775
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    8. XM_047443978.1 → XP_047299934.1  coiled-coil domain-containing protein 150 isoform X9

    9. XM_011510987.3 → XP_011509289.1  coiled-coil domain-containing protein 150 isoform X8

      See identical proteins and their annotated locations for XP_011509289.1

      UniProtKB/TrEMBL
      B4DZ03
      Conserved Domains (1) summary
      cl25732
      Location:2 → 678
      SMC_N; RecF/RecN/SMC N terminal domain

    10. XM_017003866.2 → XP_016859355.1  coiled-coil domain-containing protein 150 isoform X8

      UniProtKB/TrEMBL
      B4DZ03
      Conserved Domains (1) summary
      cl25732
      Location:2 → 678
      SMC_N; RecF/RecN/SMC N terminal domain

    11. XM_011510988.3 → XP_011509290.1  coiled-coil domain-containing protein 150 isoform X10

      Conserved Domains (2) summary
      pfam07851
      Location:352 → 434
      TMPIT; TMPIT-like protein
      cl09914
      Location:248 → 388
      PHA_synth_III_E; Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      197123662..197216860
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054341467.1 → XP_054197442.1  coiled-coil domain-containing protein 150 isoform X1

    2. XM_054341469.1 → XP_054197444.1  coiled-coil domain-containing protein 150 isoform X3

    3. XM_054341470.1 → XP_054197445.1  coiled-coil domain-containing protein 150 isoform X4

    4. XM_054341468.1 → XP_054197443.1  coiled-coil domain-containing protein 150 isoform X2

    5. XM_054341473.1 → XP_054197448.1  coiled-coil domain-containing protein 150 isoform X7

    6. XM_054341476.1 → XP_054197451.1  coiled-coil domain-containing protein 150 isoform X9

    7. XM_054341471.1 → XP_054197446.1  coiled-coil domain-containing protein 150 isoform X5

    8. XM_054341472.1 → XP_054197447.1  coiled-coil domain-containing protein 150 isoform X6

    9. XM_054341475.1 → XP_054197450.1  coiled-coil domain-containing protein 150 isoform X8

      UniProtKB/TrEMBL
      B4DZ03

    10. XM_054341474.1 → XP_054197449.1  coiled-coil domain-containing protein 150 isoform X8

      UniProtKB/TrEMBL
      B4DZ03

    11. XM_054341477.1 → XP_054197452.1  coiled-coil domain-containing protein 150 isoform X10

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_173466.1: Suppressed sequence

      Description
      NM_173466.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    2. NM_173646.1: Suppressed sequence

      Description
      NM_173646.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NCX0.2 GenPept UniProtKB/Swiss-Prot:Q8NCX0

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