TRIM37 tripartite motif containing 37 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRIM37provided by HGNC
Official Full Name: tripartite motif containing 37provided by HGNC
Primary source: HGNC:HGNC:7523
See related: Ensembl:ENSG00000108395 MIM:605073; AllianceGenome:HGNC:7523
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MUL; POB1; TEF3
Summary: This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. Mutations in this gene are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. TRIM37 localizes in peroxisomal membranes, and has been implicated in human peroxisomal biogenesis disorders. [provided by RefSeq, Jul 2020]
Expression: Broad expression in testis (RPKM 19.8), brain (RPKM 14.1) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q22

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (58967201..59106880, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (59835276..59974976, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (57060010..57184241, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRIM37 interacts with EZH2 to epigenetically suppress PTCH1 and regulate stemness in glioma stem cells through sonic hedgehog pathway.
Title: TRIM37 interacts with EZH2 to epigenetically suppress PTCH1 and regulate stemness in glioma stem cells through sonic hedgehog pathway.
TRIM37 promotes the aggressiveness of ovarian cancer cells and increases c-Myc expression by binding to HUWE1.
Title: TRIM37 promotes the aggressiveness of ovarian cancer cells and increases c-Myc expression by binding to HUWE1.
TRIM37 Augments AP-2gamma Transcriptional Activity and Cellular Localization via K63-linked Ubiquitination to Drive Breast Cancer Progression.
Title: TRIM37 Augments AP-2γ Transcriptional Activity and Cellular Localization via K63-linked Ubiquitination to Drive Breast Cancer Progression.
Liver pathology and biochemistry in patients with mutations in TRIM37 gene (Mulibrey nanism).
Title: Liver pathology and biochemistry in patients with mutations in TRIM37 gene (Mulibrey nanism).
TRIM37 Promotes Pancreatic Cancer Progression through Modulation of Cell Growth, Migration, Invasion, and Tumor Immune Microenvironment.
Title: TRIM37 Promotes Pancreatic Cancer Progression through Modulation of Cell Growth, Migration, Invasion, and Tumor Immune Microenvironment.
TRIM37 prevents formation of centriolar protein assemblies by regulating Centrobin.
Title: TRIM37 prevents formation of centriolar protein assemblies by regulating Centrobin.
Circular RNA circRNA_101996 promoted cervical cancer development by regulating miR-1236-3p/TRIM37 axis.
Title: Circular RNA circRNA_101996 promoted cervical cancer development by regulating miR-1236-3p/TRIM37 axis.
TRIM37 orchestrates renal cell carcinoma progression via histone H2A ubiquitination-dependent manner.
Title: TRIM37 orchestrates renal cell carcinoma progression via histone H2A ubiquitination-dependent manner.
ASB16-AS1 up-regulated and phosphorylated TRIM37 to activate NF-kappaB pathway and promote proliferation, stemness, and cisplatin resistance of gastric cancer.
Title: ASB16-AS1 up-regulated and phosphorylated TRIM37 to activate NF-κB pathway and promote proliferation, stemness, and cisplatin resistance of gastric cancer.
TRIM37 prevents formation of condensate-organized ectopic spindle poles to ensure mitotic fidelity.
Title: TRIM37 prevents formation of condensate-organized ectopic spindle poles to ensure mitotic fidelity.

Submit: New GeneRIF Correction See all GeneRIFs (38)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Mulibrey nanism syndrome MedGen: C0524582 OMIM: 253250 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Meta-analysis identifies four new loci associated with testicular germ cell tumor. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH11893 (e-PCR)
- UniSTS:75531

PMC310730P3 (e-PCR)
- UniSTS:272661

D17S1670 (e-PCR)
- UniSTS:16410

G20499 (e-PCR)
- UniSTS:2352

A005U07 (e-PCR)
- UniSTS:2353

A009B30 (e-PCR)
- UniSTS:6705

GDB:314385 (e-PCR)
- UniSTS:156475

GDB:314677 (e-PCR)
- UniSTS:45662

WI-18603 (e-PCR)
- UniSTS:34666

G42202 (e-PCR)
- UniSTS:93305

G42207 (e-PCR)
- UniSTS:93310

G42231 (e-PCR)
- UniSTS:93334

D17S1389E (e-PCR)
- UniSTS:150442

RH91179 (e-PCR)
- UniSTS:92332

D17S1449E (e-PCR)
- UniSTS:150489

G32388 (e-PCR)
- UniSTS:116976

D17S1680 (e-PCR)
- UniSTS:64754

WI-15527 (e-PCR)
- UniSTS:73204

A007E14 (e-PCR)
- UniSTS:57333

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables histone H2AK119 ubiquitin ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables tumor necrosis factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables tumor necrosis factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aggresome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in aggresome assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of NF-kappaB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of centriole replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression, epigenetic	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of NF-kappaB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autoubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein autoubiquitination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of protein import into peroxisome matrix	IDA Inferred from Direct Assay more info	PubMed
involved_in protein monoubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein monoubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein stabilization	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of ESC/E(Z) complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESC/E(Z) complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in aggresome	IBA Inferred from Biological aspect of Ancestor more info
located_in aggresome	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in peroxisomal membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in peroxisomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase TRIM37

Names: RING-B-box-coiled-coil protein; RING-type E3 ubiquitin transferase TRIM37; mulibrey nanism protein

NP_001005207.1

EC 2.3.2.27

NP_001307916.1

EC 2.3.2.27

NP_001307917.1

EC 2.3.2.27

NP_001307918.1

EC 2.3.2.27

NP_001307919.1

EC 2.3.2.27

NP_001340011.1

EC 2.3.2.27

NP_001340012.1

EC 2.3.2.27

NP_001340013.1

EC 2.3.2.27

NP_001340014.1

EC 2.3.2.27

NP_001340015.1

EC 2.3.2.27

NP_056109.1

EC 2.3.2.27

XP_005257442.1

EC 2.3.2.27

XP_011523133.1

EC 2.3.2.27

XP_011523134.1

EC 2.3.2.27

XP_011523135.1

EC 2.3.2.27

XP_011523136.1

EC 2.3.2.27

XP_011523138.1

EC 2.3.2.27

XP_016880151.1

EC 2.3.2.27

XP_016880152.1

EC 2.3.2.27

XP_016880154.1

EC 2.3.2.27

XP_016880156.1

EC 2.3.2.27

XP_016880158.1

EC 2.3.2.27

XP_016880159.1

EC 2.3.2.27

XP_016880162.1

EC 2.3.2.27

XP_047292062.1

EC 2.3.2.27

XP_047292063.1

EC 2.3.2.27

XP_047292064.1

EC 2.3.2.27

XP_047292065.1

EC 2.3.2.27

XP_047292066.1

EC 2.3.2.27

XP_047292067.1

EC 2.3.2.27

XP_047292068.1

EC 2.3.2.27

XP_047292069.1

EC 2.3.2.27

XP_047292070.1

EC 2.3.2.27

XP_047292071.1

EC 2.3.2.27

XP_047292072.1

EC 2.3.2.27

XP_047292073.1

EC 2.3.2.27

XP_047292074.1

EC 2.3.2.27

XP_047292075.1

EC 2.3.2.27

XP_047292076.1

EC 2.3.2.27

XP_047292077.1

EC 2.3.2.27

XP_047292078.1

EC 2.3.2.27

XP_047292079.1

EC 2.3.2.27

XP_047292080.1

EC 2.3.2.27

XP_047292081.1

EC 2.3.2.27

XP_047292082.1

EC 2.3.2.27

XP_054172173.1

EC 2.3.2.27

XP_054172174.1

EC 2.3.2.27

XP_054172175.1

EC 2.3.2.27

XP_054172176.1

EC 2.3.2.27

XP_054172177.1

EC 2.3.2.27

XP_054172178.1

EC 2.3.2.27

XP_054172179.1

EC 2.3.2.27

XP_054172180.1

EC 2.3.2.27

XP_054172181.1

EC 2.3.2.27

XP_054172182.1

EC 2.3.2.27

XP_054172183.1

EC 2.3.2.27

XP_054172184.1

EC 2.3.2.27

XP_054172185.1

EC 2.3.2.27

XP_054172186.1

EC 2.3.2.27

XP_054172187.1

EC 2.3.2.27

XP_054172188.1

EC 2.3.2.27

XP_054172189.1

EC 2.3.2.27

XP_054172190.1

EC 2.3.2.27

XP_054172191.1

EC 2.3.2.27

XP_054172192.1

EC 2.3.2.27

XP_054172193.1

EC 2.3.2.27

XP_054172194.1

EC 2.3.2.27

XP_054172195.1

EC 2.3.2.27

XP_054172196.1

EC 2.3.2.27

XP_054172197.1

EC 2.3.2.27

XP_054172198.1

EC 2.3.2.27

XP_054172199.1

EC 2.3.2.27

XP_054172200.1

EC 2.3.2.27

XP_054172201.1

EC 2.3.2.27

XP_054172202.1

EC 2.3.2.27

XP_054172203.1

EC 2.3.2.27

XP_054172204.1

EC 2.3.2.27

XP_054172205.1

EC 2.3.2.27

XP_054172206.1

EC 2.3.2.27

XP_054172207.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_009298.2 RefSeqGene

Range

5000..113678

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001005207.5 → NP_001005207.1 E3 ubiquitin-protein ligase TRIM37 isoform a

See identical proteins and their annotated locations for NP_001005207.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) and variant 1 encode the same isoform (a).

Source sequence(s)

AI307801, AK292459, BC036012, DC351295

Consensus CDS

CCDS45746.1

UniProtKB/Swiss-Prot

A8K0V9, A8K8U4, A8MZ79, B4DGZ3, F8WEE6, O94972, Q7Z3E6, Q8IYF7, Q8WYF7

Related

ENSP00000376785.3, ENST00000393066.7

Conserved Domains (4) summary

smart00502
Location:132 → 254

BBC; B-Box C-terminal domain

cd00162
Location:15 → 58

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd03773
Location:273 → 406

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

pfam00643
Location:90 → 132

zf-B_box; B-box zinc finger
NM_001320987.3 → NP_001307916.1 E3 ubiquitin-protein ligase TRIM37 isoform b

Status: REVIEWED

Source sequence(s)

AB020705, AC099850, AC100832, AI610736, AK294850, DC343932

Consensus CDS

CCDS82174.1

UniProtKB/Swiss-Prot

O94972

Related

ENSP00000376784.2, ENST00000393065.6

Conserved Domains (3) summary

smart00502
Location:98 → 220

BBC; B-Box C-terminal domain

cd03773
Location:239 → 372

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

pfam00643
Location:56 → 98

zf-B_box; B-box zinc finger
NM_001320988.3 → NP_001307917.1 E3 ubiquitin-protein ligase TRIM37 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (4) and variant 5 encode the same isoform (c).

Source sequence(s)

AC005207, AC036154, AC099850, AC100832

Conserved Domains (4) summary

smart00502
Location:132 → 254

BBC; B-Box C-terminal domain

cd00162
Location:15 → 58

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd03773
Location:273 → 406

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

pfam00643
Location:90 → 132

zf-B_box; B-box zinc finger
NM_001320989.3 → NP_001307918.1 E3 ubiquitin-protein ligase TRIM37 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (5) and variant 4 encode the same isoform (c).

Source sequence(s)

AC005207, AC036154, AC099850, AC100832

Conserved Domains (4) summary

smart00502
Location:132 → 254

BBC; B-Box C-terminal domain

cd00162
Location:15 → 58

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd03773
Location:273 → 406

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

pfam00643
Location:90 → 132

zf-B_box; B-box zinc finger
NM_001320990.3 → NP_001307919.1 E3 ubiquitin-protein ligase TRIM37 isoform d

Status: REVIEWED

Source sequence(s)

AC100832, BX537955, DC343932

UniProtKB/Swiss-Prot

O94972

Conserved Domains (2) summary

smart00502
Location:10 → 132

BBC; B-Box C-terminal domain

cd03773
Location:151 → 284

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
NM_001353082.2 → NP_001340011.1 E3 ubiquitin-protein ligase TRIM37 isoform e

Status: REVIEWED

Source sequence(s)

AC005207, AC036154, AC099850, AC100832

Conserved Domains (4) summary

smart00502
Location:98 → 220

BBC; B-Box C-terminal domain

smart00336
Location:57 → 98

BBOX; B-Box-type zinc finger

cd03773
Location:239 → 372

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

cl17238
Location:6 → 21

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
NM_001353083.2 → NP_001340012.1 E3 ubiquitin-protein ligase TRIM37 isoform f

Status: REVIEWED

Source sequence(s)

AC005207, AC036154, AC099850, AC100832

Conserved Domains (1) summary

cd03773
Location:28 → 161

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
NM_001353084.2 → NP_001340013.1 E3 ubiquitin-protein ligase TRIM37 isoform g

Status: REVIEWED

Source sequence(s)

AC005207, AC036154, AC099850, AC100832

Conserved Domains (4) summary

smart00502
Location:132 → 254

BBC; B-Box C-terminal domain

smart00336
Location:91 → 132

BBOX; B-Box-type zinc finger

cd03773
Location:273 → 406

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

cd16619
Location:13 → 55

mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
NM_001353085.2 → NP_001340014.1 E3 ubiquitin-protein ligase TRIM37 isoform h

Status: REVIEWED

Source sequence(s)

AC005207, AC036154, AC099850, AC100832

Conserved Domains (2) summary

cd03773
Location:119 → 252

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

cl25407
Location:1 → 100

ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
NM_001353086.2 → NP_001340015.1 E3 ubiquitin-protein ligase TRIM37 isoform i

Status: REVIEWED

Source sequence(s)

AC005207, AC036154, AC099850, AC100832

Conserved Domains (4) summary

smart00502
Location:132 → 254

BBC; B-Box C-terminal domain

smart00336
Location:91 → 132

BBOX; B-Box-type zinc finger

cd03773
Location:270 → 389

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

cd16619
Location:13 → 55

mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
NM_015294.6 → NP_056109.1 E3 ubiquitin-protein ligase TRIM37 isoform a

See identical proteins and their annotated locations for NP_056109.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) and variant 2 encode the same isoform (a).

Source sequence(s)

AB020705, AK289674, CN388771, DC351295

Consensus CDS

CCDS32694.1

UniProtKB/Swiss-Prot

A8K0V9, A8K8U4, A8MZ79, B4DGZ3, F8WEE6, O94972, Q7Z3E6, Q8IYF7, Q8WYF7

Related

ENSP00000262294.7, ENST00000262294.12

Conserved Domains (4) summary

smart00502
Location:132 → 254

BBC; B-Box C-terminal domain

cd00162
Location:15 → 58

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd03773
Location:273 → 406

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

pfam00643
Location:90 → 132

zf-B_box; B-box zinc finger

RNA

NR_148346.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC005207, AC036154, AC099850, AC100832

Related

ENST00000577554.5
NR_148347.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC005207, AC036154, AC099850, AC100832

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

58967201..59106880 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047436110.1 → XP_047292066.1 E3 ubiquitin-protein ligase TRIM37 isoform X13
XM_047436107.1 → XP_047292063.1 E3 ubiquitin-protein ligase TRIM37 isoform X9
XM_047436111.1 → XP_047292067.1 E3 ubiquitin-protein ligase TRIM37 isoform X15
XM_017024663.3 → XP_016880152.1 E3 ubiquitin-protein ligase TRIM37 isoform X4
XM_017024662.2 → XP_016880151.1 E3 ubiquitin-protein ligase TRIM37 isoform X2
XM_047436122.1 → XP_047292078.1 E3 ubiquitin-protein ligase TRIM37 isoform X29
XM_047436121.1 → XP_047292077.1 E3 ubiquitin-protein ligase TRIM37 isoform X28
XM_047436114.1 → XP_047292070.1 E3 ubiquitin-protein ligase TRIM37 isoform X19
XM_047436113.1 → XP_047292069.1 E3 ubiquitin-protein ligase TRIM37 isoform X18
XM_047436117.1 → XP_047292073.1 E3 ubiquitin-protein ligase TRIM37 isoform X23
XM_017024667.2 → XP_016880156.1 E3 ubiquitin-protein ligase TRIM37 isoform X16

Conserved Domains (4) summary

smart00502
Location:132 → 254

BBC; B-Box C-terminal domain

smart00336
Location:91 → 132

BBOX; B-Box-type zinc finger

cd03773
Location:270 → 389

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

cd16619
Location:13 → 55

mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
XM_047436108.1 → XP_047292064.1 E3 ubiquitin-protein ligase TRIM37 isoform X10
XM_047436123.1 → XP_047292079.1 E3 ubiquitin-protein ligase TRIM37 isoform X30
XM_047436116.1 → XP_047292072.1 E3 ubiquitin-protein ligase TRIM37 isoform X21
XM_047436115.1 → XP_047292071.1 E3 ubiquitin-protein ligase TRIM37 isoform X20
XM_005257385.2 → XP_005257442.1 E3 ubiquitin-protein ligase TRIM37 isoform X6

Conserved Domains (4) summary

smart00502
Location:132 → 254

BBC; B-Box C-terminal domain

smart00336
Location:91 → 132

BBOX; B-Box-type zinc finger

cd03773
Location:273 → 406

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

cd16619
Location:13 → 55

mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
XM_011524832.3 → XP_011523134.1 E3 ubiquitin-protein ligase TRIM37 isoform X3

Conserved Domains (4) summary

smart00502
Location:132 → 254

BBC; B-Box C-terminal domain

cd00162
Location:15 → 58

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd03773
Location:273 → 406

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

pfam00643
Location:90 → 132

zf-B_box; B-box zinc finger
XM_017024665.2 → XP_016880154.1 E3 ubiquitin-protein ligase TRIM37 isoform X11
XM_047436106.1 → XP_047292062.1 E3 ubiquitin-protein ligase TRIM37 isoform X7
XM_047436109.1 → XP_047292065.1 E3 ubiquitin-protein ligase TRIM37 isoform X12
XM_011524831.2 → XP_011523133.1 E3 ubiquitin-protein ligase TRIM37 isoform X1

Conserved Domains (4) summary

smart00502
Location:132 → 254

BBC; B-Box C-terminal domain

cd00162
Location:15 → 58

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd03773
Location:273 → 406

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

pfam00643
Location:90 → 132

zf-B_box; B-box zinc finger
XM_011524836.2 → XP_011523138.1 E3 ubiquitin-protein ligase TRIM37 isoform X14

Conserved Domains (4) summary

smart00502
Location:132 → 254

BBC; B-Box C-terminal domain

cd00162
Location:15 → 58

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd03773
Location:273 → 406

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

pfam00643
Location:90 → 132

zf-B_box; B-box zinc finger
XM_047436112.1 → XP_047292068.1 E3 ubiquitin-protein ligase TRIM37 isoform X17
XM_011524834.2 → XP_011523136.1 E3 ubiquitin-protein ligase TRIM37 isoform X8

Conserved Domains (3) summary

smart00502
Location:98 → 220

BBC; B-Box C-terminal domain

cd03773
Location:239 → 372

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

pfam00643
Location:56 → 98

zf-B_box; B-box zinc finger
XM_011524833.2 → XP_011523135.1 E3 ubiquitin-protein ligase TRIM37 isoform X5

Conserved Domains (4) summary

smart00502
Location:132 → 254

BBC; B-Box C-terminal domain

cd00162
Location:15 → 58

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd03773
Location:270 → 389

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

pfam00643
Location:90 → 132

zf-B_box; B-box zinc finger
XM_047436118.1 → XP_047292074.1 E3 ubiquitin-protein ligase TRIM37 isoform X24
XM_017024673.3 → XP_016880162.1 E3 ubiquitin-protein ligase TRIM37 isoform X34
XM_047436125.1 → XP_047292081.1 E3 ubiquitin-protein ligase TRIM37 isoform X32
XM_047436124.1 → XP_047292080.1 E3 ubiquitin-protein ligase TRIM37 isoform X31
XM_017024669.3 → XP_016880158.1 E3 ubiquitin-protein ligase TRIM37 isoform X22
XM_047436126.1 → XP_047292082.1 E3 ubiquitin-protein ligase TRIM37 isoform X33
XM_047436120.1 → XP_047292076.1 E3 ubiquitin-protein ligase TRIM37 isoform X26
XM_017024670.3 → XP_016880159.1 E3 ubiquitin-protein ligase TRIM37 isoform X27
XM_047436119.1 → XP_047292075.1 E3 ubiquitin-protein ligase TRIM37 isoform X25