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    FSIP1 fibrous sheath interacting protein 1 [ Homo sapiens (human) ]

    Gene ID: 161835, updated on 27-Nov-2024

    Summary

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    Official Symbol
    FSIP1provided by HGNC
    Official Full Name
    fibrous sheath interacting protein 1provided by HGNC
    Primary source
    HGNC:HGNC:21674
    See related
    Ensembl:ENSG00000150667 MIM:615795; AllianceGenome:HGNC:21674
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSD10
    Expression
    Biased expression in appendix (RPKM 7.4), bone marrow (RPKM 3.4) and 11 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FSIP1 in Genome Data Viewer
    Location:
    15q14
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (39597440..39782841, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (37402151..37588039, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (39892232..40075042, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:39872371-39873108 Neighboring gene uncharacterized LOC124903470 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:39885600-39886799 Neighboring gene THBS1 intronic transcript 1 Neighboring gene thrombospondin 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:39909535-39910734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9216 Neighboring gene uncharacterized LOC105370785 Neighboring gene NANOG hESC enhancer GRCh37_chr15:39958804-39959320 Neighboring gene Sharpr-MPRA regulatory region 4200 Neighboring gene uncharacterized LOC105370941 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9217 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6312 Neighboring gene G protein-coupled receptor 176 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:40176182-40176852 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:40176853-40177522 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:40177802-40178334 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:40178335-40178866 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:40179399-40179929 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:40186807-40187332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40200676-40201176 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:40209802-40209908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40211506-40212311

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. FSIP1 enhances the therapeutic sensitivity to CDK4/6 inhibitors in triple-negative breast cancer patients by activating the Nanog pathway. Chen G, et al. Sci China Life Sci, 2023 Dec. PMID 37460715
    2. Elevated expression of cancer/testis antigen FSIP1 in ER-positive breast tumors. Chapman KB, et al. Biomark Med, 2013 Aug. PMID 23905897
    3. Expression and clinicopathological significance of FSIP1 in breast cancer. Zhang H, et al. Oncotarget, 2015 Apr 30. PMID 25826084, Free PMC Article
    4. Elevated fibrous sheath interacting protein 1 levels are associated with poor prognosis in non-small cell lung cancer patients. Mao Y, et al. Oncotarget, 2017 Feb 14. PMID 28086239, Free PMC Article
    5. Positive association between aspirin-intolerant asthma and genetic polymorphisms of FSIP1: a case-case study. Kim JY, et al. BMC Pulm Med, 2010 Jun 1. PMID 20513247, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FSIP1 enhances the therapeutic sensitivity to CDK4/6 inhibitors in triple-negative breast cancer patients by activating the Nanog pathway.
      Title: FSIP1 enhances the therapeutic sensitivity to CDK4/6 inhibitors in triple-negative breast cancer patients by activating the Nanog pathway.
    2. FSIP1 Is Associated with Poor Prognosis and Can Be Used to Construct a Prognostic Model in Gastric Cancer.
      Title: FSIP1 Is Associated with Poor Prognosis and Can Be Used to Construct a Prognostic Model in Gastric Cancer.
    3. Loss-of-function variants in FSIP1 identified by targeted sequencing are associated with one particular subtype of mucosal melanoma.
      Title: Loss-of-function variants in FSIP1 identified by targeted sequencing are associated with one particular subtype of mucosal melanoma.
    4. FSIP1 bound to the multidrug resistance protein 1 (MRP1) and stabilized it, and knocking out FSIP1 decreased MRP1 expression and increased cellular docetaxel accumulation. In sum, FSIP1 promotes breast carcinogenesis and mediates docetaxel resistance.
      Title: Over-expression of FSIP1 promotes breast cancer progression and confers resistance to docetaxel via MRP1 stabilization.
    5. FSIP1 overexpression correlated with decreased overall survival in hormone receptor-positive breast cancer patients.
      Title: FSIP1 is correlated with estrogen receptor status and poor prognosis.
    6. High FSIP1 expression is associated with drug resistance in triple-negative breast cancer.
      Title: FSIP1 regulates autophagy in breast cancer.
    7. FSIP1 binds HER2 directly, which regulates breast cancer growth and invasiveness
      Title: FSIP1 binds HER2 directly to regulate breast cancer growth and invasiveness.
    8. Results suggest that evaluating fibrous sheath interacting protein 1 (FSIP1) status in addition to TNM stage during routine pathological examinations could improve prognostic predictions in non-small cell lung cancer (NSCLC) patients.
      Title: Elevated fibrous sheath interacting protein 1 levels are associated with poor prognosis in non-small cell lung cancer patients.
    9. FSIP1 may play an important role in the tumorigenesis and invasion of breast cancer and is a potential biomarker for breast cancer diagnosis or prognosis.
      Title: Expression and clinicopathological significance of FSIP1 in breast cancer.
    10. prevalence and uniformity of FSIP1 expression in breast tumors
      Title: Elevated expression of cancer/testis antigen FSIP1 in ER-positive breast tumors.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    integrase gag-pol Analysis of HIV-1 proviral integration sites in antiretroviral treatment patients indicates that FSIP1 gene favors HIV-1 integration for expansion and persistence of infected cells, suggesting HIV-1 IN interacts with FSIP1 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ35989

    General protein information

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    Preferred Names
    fibrous sheath-interacting protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324338.2 → NP_001311267.1  fibrous sheath-interacting protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC023908, AC037198
      Consensus CDS
      CCDS10050.1
      UniProtKB/Swiss-Prot
      Q6X2C8, Q86Y89, Q8NA03
      Conserved Domains (1) summary
      pfam15554
      Location:2 → 394
      FSIP1; FSIP1 family

    2. NM_152597.5 → NP_689810.3  fibrous sheath-interacting protein 1

      See identical proteins and their annotated locations for NP_689810.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AC023908, AC037198, AK093308, BX642685
      Consensus CDS
      CCDS10050.1
      UniProtKB/Swiss-Prot
      Q6X2C8, Q86Y89, Q8NA03
      Related
      ENSP00000280236.3, ENST00000350221.4
      Conserved Domains (1) summary
      pfam15554
      Location:2 → 394
      FSIP1; FSIP1 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      39597440..39782841 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011521305.4 → XP_011519607.1  fibrous sheath-interacting protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011519607.1

      UniProtKB/Swiss-Prot
      Q6X2C8, Q86Y89, Q8NA03
      Conserved Domains (1) summary
      pfam15554
      Location:2 → 394
      FSIP1; FSIP1 family

    2. XM_011521306.3 → XP_011519608.1  fibrous sheath-interacting protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011519608.1

      UniProtKB/Swiss-Prot
      Q6X2C8, Q86Y89, Q8NA03
      Conserved Domains (1) summary
      pfam15554
      Location:2 → 394
      FSIP1; FSIP1 family

    3. XM_011521311.4 → XP_011519613.1  fibrous sheath-interacting protein 1 isoform X4

      Conserved Domains (1) summary
      pfam15554
      Location:1 → 184
      FSIP1; FSIP1 family

    4. XM_017021972.3 → XP_016877461.1  fibrous sheath-interacting protein 1 isoform X4

      Conserved Domains (1) summary
      pfam15554
      Location:1 → 184
      FSIP1; FSIP1 family

    5. XM_011521309.4 → XP_011519611.1  fibrous sheath-interacting protein 1 isoform X3

      Conserved Domains (1) summary
      NF033479
      Location:5 → 296
      Efa1_rel_toxin; LifA/Efa1-related large cytotoxin

    6. XM_047432212.1 → XP_047288168.1  fibrous sheath-interacting protein 1 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      37402151..37588039 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377408.1 → XP_054233383.1  fibrous sheath-interacting protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q6X2C8, Q86Y89, Q8NA03

    2. XM_054377409.1 → XP_054233384.1  fibrous sheath-interacting protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q6X2C8, Q86Y89, Q8NA03

    3. XM_054377412.1 → XP_054233387.1  fibrous sheath-interacting protein 1 isoform X4

    4. XM_054377413.1 → XP_054233388.1  fibrous sheath-interacting protein 1 isoform X4

    5. XM_054377411.1 → XP_054233386.1  fibrous sheath-interacting protein 1 isoform X3

    6. XM_054377410.1 → XP_054233385.1  fibrous sheath-interacting protein 1 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NA03.1 GenPept UniProtKB/Swiss-Prot:Q8NA03

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