IKBIP IKBKB interacting protein [Homo sapiens (human)] - Gene

Summary

Official Symbol: IKBIPprovided by HGNC
Official Full Name: IKBKB interacting proteinprovided by HGNC
Primary source: HGNC:HGNC:26430
See related: Ensembl:ENSG00000166130 MIM:609861; AllianceGenome:HGNC:26430
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IKIP
Summary: Predicted to be involved in response to X-ray. Located in endoplasmic reticulum and nucleolus. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in placenta (RPKM 6.8), urinary bladder (RPKM 5.4) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q23.1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (98613404..98644788, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (98586371..98617716, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (99007182..99038566, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IKBIP promotes tumor development via the akt signaling pathway in esophageal squamous cell carcinoma.
Title: IKBIP promotes tumor development via the akt signaling pathway in esophageal squamous cell carcinoma.
IKBIP is a Predictive Biomarker Related to Immunosuppressive Microenvironment in Digestive System Malignancies.
Title: IKBIP is a Predictive Biomarker Related to Immunosuppressive Microenvironment in Digestive System Malignancies.
IKBIP, a novel glioblastoma biomarker, maintains abnormal proliferation of tumor cells by inhibiting the ubiquitination and degradation of CDK4.
Title: IKBIP, a novel glioblastoma biomarker, maintains abnormal proliferation of tumor cells by inhibiting the ubiquitination and degradation of CDK4.
hsa_circ_0072389, hsa_circ_0072386, hsa_circ_0008621, hsa_circ_0072387, and hsa_circ_0072391 aggravate glioma via miR-338-5p/IKBIP.
Title: hsa_circ_0072389, hsa_circ_0072386, hsa_circ_0008621, hsa_circ_0072387, and hsa_circ_0072391 aggravate glioma via miR-338-5p/IKBIP.
study identifies a previously unrecognized role for IKIP in the negative regulation of NF-kappaB activation by inhibition of IKKalpha/beta phosphorylation through the disruption of IKK complex formation
Title: IKIP Negatively Regulates NF-κB Activation and Inflammation through Inhibition of IKKα/β Phosphorylation.
We conclude that IKIP is a novel p53 target gene with proapoptotic function.(IKIP1 protein, human)
Title: A highly conserved proapoptotic gene, IKIP, located next to the APAF1 gene locus, is regulated by p53.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp160, precursor	env	HIV-1 gp160 interacts with IKBIP; predicted interaction to be within the endoplasmic reticulum and involved in NFKB circuitry	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

D8S2278 (e-PCR)
- UniSTS:473906

D8S2279 (e-PCR)
- UniSTS:473907

L18426 (e-PCR)
- UniSTS:34648

D1S1423 (e-PCR)
- UniSTS:149619

RH48145 (e-PCR)
- UniSTS:51068

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in response to X-ray	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
located_in membrane	HDA more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: inhibitor of nuclear factor kappa-B kinase-interacting protein

Names: I kappa B kinase interacting protein; IKK interacting protein; i kappa-B kinase-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153687.4 → NP_710154.1 inhibitor of nuclear factor kappa-B kinase-interacting protein isoform 1

See identical proteins and their annotated locations for NP_710154.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC013283, AJ539425, BC058933, BM468651

Consensus CDS

CCDS9068.1

UniProtKB/Swiss-Prot

Q70UQ0

Related

ENSP00000299157.4, ENST00000299157.5

Conserved Domains (1) summary

cl25732
Location:83 → 348

SMC_N; RecF/RecN/SMC N terminal domain
NM_201612.4 → NP_963906.1 inhibitor of nuclear factor kappa-B kinase-interacting protein isoform 2

See identical proteins and their annotated locations for NP_963906.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate exon at its 3'-terminal exon, compared to variant 1, which results in a protein (isoform 2) with a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC013283, AJ539426

Consensus CDS

CCDS9067.1

UniProtKB/Swiss-Prot

Q6ZWH4, Q70UP9, Q70UQ0, Q86V91, Q96ND2

Related

ENSP00000343471.2, ENST00000342502.6

Conserved Domains (1) summary

cl23887
Location:59 → 222

DUF4349; Domain of unknown function (DUF4349)
NM_201613.4 → NP_963907.1 inhibitor of nuclear factor kappa-B kinase-interacting protein isoform 3

See identical proteins and their annotated locations for NP_963907.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate exon at its 3'-terminal exon and lacks an internal exon, compared to variant 1, which results in a protein (isoform 3; also known as 3.1) with a shorter and distinct C-terminus, compared to isoform 1. The 3'-terminal exon of variant 3 contains a longer ORF which can potentially encode a protein (called isoform 3.2) that matches the C-terminus of isoform 2; however, this protein is not predicted to be translated because the ORF is overlapped by the upstream ORF encoding isoform 3.

Source sequence(s)

AC013283, AJ539427

Consensus CDS

CCDS41822.1

UniProtKB/Swiss-Prot

Q70UQ0

Related

ENSP00000376762.3, ENST00000393042.3