PYY peptide YY [Homo sapiens (human)] - Gene

Summary

Official Symbol: PYYprovided by HGNC
Official Full Name: peptide YYprovided by HGNC
Primary source: HGNC:HGNC:9748
See related: Ensembl:ENSG00000131096 MIM:600781; AllianceGenome:HGNC:9748
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PYY1; PYY-I
Summary: This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded preproprotein is proteolytically processed to generate two alternative peptide products that differ in length by three amino acids. These peptides, secreted by endocrine cells in the gut, exhibit different binding affinities for each of the neuropeptide Y receptors. Binding of the encoded peptides to these receptors mediates regulation of pancreatic secretion, gut mobility and energy homeostasis. Rare variations in this gene could increase susceptibility to obesity and elevated serum levels of the encoded peptides may be associated with anorexia nervosa. [provided by RefSeq, Feb 2016]
Expression: Biased expression in colon (RPKM 24.9) and small intestine (RPKM 4.4) See more
Orthologs: mouse all
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Genomic context

Location:: 17q21.31

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (43952733..44004445, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (44805282..44856956, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (42030101..42081813, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RET Signaling Persists in the Adult Intestine and Stimulates Motility by Limiting PYY Release From Enteroendocrine Cells.
Title: RET Signaling Persists in the Adult Intestine and Stimulates Motility by Limiting PYY Release From Enteroendocrine Cells.
Peptide YY inhibits transcription and replication of hepatitis B virus by suppressing promoter/enhancer activity.
Title: Peptide YY inhibits transcription and replication of hepatitis B virus by suppressing promoter/enhancer activity.
Structural basis for Y2 receptor-mediated neuropeptide Y and peptide YY signaling.
Title: Structural basis for Y2 receptor-mediated neuropeptide Y and peptide YY signaling.
Emerging evidence of the relationship between fat-free mass and ghrelin, glucagon-like peptide-1, and peptide-YY.
Title: Emerging evidence of the relationship between fat-free mass and ghrelin, glucagon-like peptide-1, and peptide-YY.
Crystal structures of human neuropeptide Y (NPY) and peptide YY (PYY).
Title: Crystal structures of human neuropeptide Y (NPY) and peptide YY (PYY).
Single nucleotide polymorphism in CD36: Correlation to peptide YY levels in obese and non-obese adults.
Title: Single nucleotide polymorphism in CD36: Correlation to peptide YY levels in obese and non-obese adults.
Real-time RT-PCR revealed that Intermittent Hypoxia significantly increased the mRNA levels of peptide YY (PYY), glucagon-like peptide-1 (GLP-1), and neurotensin (NTS) in Caco-2 cells.
Title: Intermittent Hypoxia Up-Regulates Gene Expressions of Peptide YY (PYY), Glucagon-like Peptide-1 (GLP-1), and Neurotensin (NTS) in Enteroendocrine Cells.
the current review aims to compile, evaluate and summarise current knowledge on PYY, with particular emphasis on obesity and diabetes treatment, and the importance of specific Y receptor interactions for this.
Title: Emerging therapeutic potential for peptide YY for obesity-diabetes.
Data show that peptide YY (PYY) mRNA levels were ~ 40,000-fold higher in mouse than human islets, suggesting a more important role of locally secreted Pyy in mouse islets.
Title: Defining G protein-coupled receptor peptide ligand expressomes and signalomes in human and mouse islets.
Data suggest that dose/intensity-response relationships exist between exercise intensity and total plasma PYY levels, though the effects on total plasma GLP1 levels and hunger perceptions seem unclear. (PYY = peptide YY ; GLP1 = glucagon-like peptide 1)
Title: Total PYY and GLP-1 responses to submaximal continuous and supramaximal sprint interval cycling in men.

Submit: New GeneRIF Correction See all GeneRIFs (103)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic association with overall survival of taxane-treated lung cancer patients - A genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH80747 (e-PCR)
- UniSTS:90165

PYY_s24 (e-PCR)
- UniSTS:512661

D17S1206 (e-PCR)
- UniSTS:37845

NoName (e-PCR)
- UniSTS:480767

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables hormone activity	TAS Traceable Author Statement more info	PubMed
enables neuropeptide Y receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in feeding behavior	IBA Inferred from Biological aspect of Ancestor more info
involved_in intestinal epithelial cell differentiation	TAS Traceable Author Statement more info	PubMed
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: peptide YY

Names: peptide tyrosine tyrosine; prepro-PYY

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_023338.2 RefSeqGene

Range

55505..56712

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001394028.1 → NP_001380957.1 peptide YY isoform 1 preproprotein

Status: REVIEWED

Source sequence(s)

AC007993

Consensus CDS

CCDS32662.1

UniProtKB/Swiss-Prot

P10082, Q5U5Q6, Q6FGH8

Related

ENSP00000509262.1, ENST00000692052.1

Conserved Domains (1) summary

smart00309
Location:29 → 64

PAH; Pancreatic hormones / neuropeptide F / peptide YY family
NM_001394029.1 → NP_001380958.1 peptide YY isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AC007993

Consensus CDS

CCDS92333.1

Related

ENSP00000467310.1, ENST00000592796.2

Conserved Domains (1) summary

smart00309
Location:29 → 64

PAH; Pancreatic hormones / neuropeptide F / peptide YY family
NM_004160.6 → NP_004151.4 peptide YY isoform 1 preproprotein

Status: REVIEWED

Source sequence(s)

AC007993, AC023855

Consensus CDS

CCDS32662.1

UniProtKB/Swiss-Prot

P10082, Q5U5Q6, Q6FGH8

Related

ENSP00000353198.1, ENST00000360085.6

Conserved Domains (1) summary

smart00309
Location:29 → 64

PAH; Pancreatic hormones / neuropeptide F / peptide YY family