SLC2A3 solute carrier family 2 member 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SLC2A3provided by HGNC
Official Full Name: solute carrier family 2 member 3provided by HGNC
Primary source: HGNC:HGNC:11007
See related: Ensembl:ENSG00000059804 MIM:138170; AllianceGenome:HGNC:11007
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GLUT3
Summary: Enables D-glucose binding activity; dehydroascorbic acid transmembrane transporter activity; and hexose transmembrane transporter activity. Involved in D-glucose import across plasma membrane; galactose transmembrane transport; and transport across blood-brain barrier. Located in aggresome and plasma membrane. Biomarker of Alzheimer's disease; acanthosis nigricans; diabetes mellitus; and type 2 diabetes mellitus. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in bone marrow (RPKM 183.0), placenta (RPKM 54.5) and 11 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12p13.31

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (7919230..7936187, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (7933413..7950362, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (8071826..8088783, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SLC2A3 promotes tumor progression through lactic acid-promoted TGF-beta signaling pathway in oral squamous cell carcinoma.
Title: SLC2A3 promotes tumor progression through lactic acid-promoted TGF-β signaling pathway in oral squamous cell carcinoma.
Glut-3 Gene Knockdown as a Potential Strategy to Overcome Glioblastoma Radioresistance.
Title: Glut-3 Gene Knockdown as a Potential Strategy to Overcome Glioblastoma Radioresistance.
GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing.
Title: GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing.
Concurrent presence of diabetes affects the GLUT3 programming of glucose metabolism in glioblastoma.
Title: Concurrent presence of diabetes affects the GLUT3 programming of glucose metabolism in glioblastoma.
The YTHDC1/GLUT3/RNF183 axis forms a positive feedback loop that modulates glucose metabolism and bladder cancer progression.
Title: The YTHDC1/GLUT3/RNF183 axis forms a positive feedback loop that modulates glucose metabolism and bladder cancer progression.
Evolutionary balance between foldability and functionality of a glucose transporter.
Title: Evolutionary balance between foldability and functionality of a glucose transporter.
SLC2A3 variants in familial and sporadic congenital heart diseases in a Chinese Yunnan population.
Title: SLC2A3 variants in familial and sporadic congenital heart diseases in a Chinese Yunnan population.
RIP140 inhibits glycolysis-dependent proliferation of breast cancer cells by regulating GLUT3 expression through transcriptional crosstalk between hypoxia induced factor and p53.
Title: RIP140 inhibits glycolysis-dependent proliferation of breast cancer cells by regulating GLUT3 expression through transcriptional crosstalk between hypoxia induced factor and p53.
The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming.
Title: The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming.
miR-3189-targeted GLUT3 repression by HDAC2 knockdown inhibits glioblastoma tumorigenesis through regulating glucose metabolism and proliferation.
Title: miR-3189-targeted GLUT3 repression by HDAC2 knockdown inhibits glioblastoma tumorigenesis through regulating glucose metabolism and proliferation.

Submit: New GeneRIF Correction See all GeneRIFs (110)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of solute carrier family 2 (facilitated glucose transporter), member 3 (SLC2A3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S2278 (e-PCR)
- UniSTS:473906

PMC156606P4 (e-PCR)
- UniSTS:271411

D8S2279 (e-PCR)
- UniSTS:473907

SHGC-30912 (e-PCR)
- UniSTS:11589

RH69095 (e-PCR)
- UniSTS:58705

RH68326 (e-PCR)
- UniSTS:2134

SHGC-31620 (e-PCR)
- UniSTS:26485

RH65076 (e-PCR)
- UniSTS:92820

RH80536 (e-PCR)
- UniSTS:83643

RH78158 (e-PCR)
- UniSTS:29404

RH48707 (e-PCR)
- UniSTS:64476

SLC2A3_843 (e-PCR)
- UniSTS:277746

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables D-glucose binding	IDA Inferred from Direct Assay more info	PubMed
enables D-glucose transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables D-glucose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables dehydroascorbic acid transmembrane transporter activity	EXP Inferred from Experiment more info	PubMed
NOT enables fructose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables galactose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in D-glucose import	IBA Inferred from Biological aspect of Ancestor more info
involved_in D-glucose import across plasma membrane	IGI Inferred from Genetic Interaction more info	PubMed
involved_in D-glucose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in L-ascorbic acid metabolic process	TAS Traceable Author Statement more info
involved_in carbohydrate metabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in dehydroascorbic acid transport	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in fructose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in galactose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in transport across blood-brain barrier	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in aggresome	IDA Inferred from Direct Assay more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	HDA more info	PubMed
located_in ficolin-1-rich granule membrane	TAS Traceable Author Statement more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in secretory granule membrane	TAS Traceable Author Statement more info
located_in specific granule membrane	TAS Traceable Author Statement more info
located_in tertiary granule membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: solute carrier family 2, facilitated glucose transporter member 3

Names: GLUT-3; glucose transporter type 3, brain; solute carrier family 2 (facilitated glucose transporter), member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006931.3 → NP_008862.1 solute carrier family 2, facilitated glucose transporter member 3

See identical proteins and their annotated locations for NP_008862.1

Status: VALIDATED

Source sequence(s)

AC007536

Consensus CDS

CCDS8586.1

UniProtKB/Swiss-Prot

B2R606, D3DUU6, P11169, Q6I9U2, Q9UG15

UniProtKB/TrEMBL

B7Z966

Related

ENSP00000075120.7, ENST00000075120.12

Conserved Domains (1) summary

cd17431
Location:12 → 456

MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily