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    Tgfbr3l transforming growth factor, beta receptor III-like [ Mus musculus (house mouse) ]

    Gene ID: 100044509, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tgfbr3lprovided by MGI
    Official Full Name
    transforming growth factor, beta receptor III-likeprovided by MGI
    Primary source
    MGI:MGI:3833469
    See related
    Ensembl:ENSMUSG00000089736 AllianceGenome:MGI:3833469
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm14378; TGFR-3L
    Summary
    Predicted to enable glycosaminoglycan binding activity; transforming growth factor beta receptor activity; and type II transforming growth factor beta receptor binding activity. Predicted to contribute to transforming growth factor beta binding activity. Predicted to be involved in several processes, including epithelial to mesenchymal transition; regulation of transforming growth factor beta receptor signaling pathway; and transforming growth factor beta receptor signaling pathway. Predicted to be located in plasma membrane. Is expressed in pituitary gland. Orthologous to human TGFBR3L (transforming growth factor beta receptor 3 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in ovary adult (RPKM 77.5), adrenal adult (RPKM 71.4) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tgfbr3l in Genome Data Viewer
    Location:
    8 A1.1; 8 1.99 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (4297994..4301528)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (4248214..4251423)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 8 family, member E Neighboring gene mitogen-activated protein kinase kinase 7 Neighboring gene small nuclear RNA activating complex, polypeptide 2 Neighboring gene cortexin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TGFBR3L is an inhibin B co-receptor that regulates female fertility. Brûlé E, et al. Sci Adv, 2021 Dec 17. PMID 34910520, Free PMC Article
    2. Steroidogenic Factor 1 Regulates Transcription of the Inhibin B Coreceptor in Pituitary Gonadotrope Cells. Lin YF, et al. Endocrinology, 2022 Oct 11. PMID 35957608, Free PMC Article
    3. Targeted Disruption of Mouse Dip2B Leads to Abnormal Lung Development and Prenatal Lethality. Sah RK, et al. Int J Mol Sci, 2020 Nov 3. PMID 33153107, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Steroidogenic Factor 1 Regulates Transcription of the Inhibin B Coreceptor in Pituitary Gonadotrope Cells.
      Title: Steroidogenic Factor 1 Regulates Transcription of the Inhibin B Coreceptor in Pituitary Gonadotrope Cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glycosaminoglycan binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to transforming growth factor beta binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transforming growth factor beta receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables type II transforming growth factor beta receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in epithelial to mesenchymal transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transforming growth factor-beta receptor type 3-like protein
    Names
    TGF-beta receptor type-3-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195258.1 → NP_001182187.1  transforming growth factor-beta receptor type 3-like protein precursor

      Status: PROVISIONAL

      Source sequence(s)
      AC123029
      Consensus CDS
      CCDS57603.1
      UniProtKB/Swiss-Prot
      D3YZZ2
      Related
      ENSMUSP00000106621.2, ENSMUST00000110993.2
      Conserved Domains (1) summary
      pfam00100
      Location:52 → 148
      Zona_pellucida; Zona pellucida-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      4297994..4301528
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153694.1 → XP_036009587.1  transforming growth factor-beta receptor type 3-like protein isoform X1

      Conserved Domains (2) summary
      PHA03247
      Location:18 → 277
      PHA03247; large tegument protein UL36; Provisional
      cl27758
      Location:88 → 199
      Zona_pellucida; Zona pellucida-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3YZZ2.1 GenPept UniProtKB/Swiss-Prot:D3YZZ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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