Pggt1b protein geranylgeranyltransferase type I, beta subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pggt1bprovided by MGI
Official Full Name: protein geranylgeranyltransferase type I, beta subunitprovided by MGI
Primary source: MGI:MGI:1917514
See related: Ensembl:ENSMUSG00000024477 AllianceGenome:MGI:1917514
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BGG1; GGT1; 2610100E13; 2010207C17Rik
Summary: Predicted to enable heterocyclic compound binding activity; protein geranylgeranyltransferase activity; and zinc ion binding activity. Predicted to contribute to CAAX-protein geranylgeranyltransferase activity; peptide binding activity; and small molecule binding activity. Predicted to be involved in several processes, including positive regulation of cell cycle; positive regulation of cell population proliferation; and protein geranylgeranylation. Part of CAAX-protein geranylgeranyltransferase complex. Orthologous to human PGGT1B (protein geranylgeranyltransferase type I subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 4.5), bladder adult (RPKM 4.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 C; 18 24.45 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (46368411..46414173, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (46235344..46281089, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of PGGT1B from T cells in mice impairs RHOA function, increasing CD4+ T-cell expression of integrin alpha4beta7 and localization to colon, resulting in increased expression of inflammatory cytokines and colitis.
Title: Inhibiting PGGT1B Disrupts Function of RHOA, Resulting in T-cell Expression of Integrin α4β7 and Development of Colitis in Mice.
The results showed that the magnitude of long-term potentiation (LTP) was markedly suppressed in hippocampal slices from GGT-haplodeficient mice. Consistent with the synaptic dysfunction, there was a significant decrease in cortical spine density and cognitive function in GGT-haplodeficient mice.
Title: Systemic or Forebrain Neuron-Specific Deficiency of Geranylgeranyltransferase-1 Impairs Synaptic Plasticity and Reduces Dendritic Spine Density.
This study demonstrated that Inhibiting geranylgeranyltransferase I activity decreases spine density in central nervous system.
Title: Inhibiting geranylgeranyltransferase I activity decreases spine density in central nervous system.
A decrease in membrane-associated Rho proteins in aged brain is associated with down-regulation of GGTase-Ibeta.
Title: Impaired geranylgeranyltransferase-I regulation reduces membrane-associated Rho protein levels in aged mouse brain.
Targeting GGTase-I activates RHOA and leads to increased macrophage reverse cholesterol transport and reduced atherosclerosis development despite a significant increase in inflammation.
Title: Targeting GGTase-I activates RHOA, increases macrophage reverse cholesterol transport, and reduces atherosclerosis in mice.
deficiencies in either FTase or GGTase-I lead to severe hepatocellular disease. Our studies lay to rest the earlier notion that FTase is dispensable in adult tissues
Title: Severe hepatocellular disease in mice lacking one or both CaaX prenyltransferases.
Data show that mice lacking GGTase-I in macrophages develop severe joint inflammation resembling erosive rheumatoid arthritis.
Title: Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice.
Both Fntb and Pggt1b are required for the homeostasis of skin keratinocytes.
Title: Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI451237 (e-PCR)
- UniSTS:180027

AI551093 (e-PCR)
- UniSTS:166096

NoName (e-PCR)
- UniSTS:237794

NoName (e-PCR)
- UniSTS:237795

NoName (e-PCR)
- UniSTS:237798

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to CAAX-protein geranylgeranyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to CAAX-protein geranylgeranyltransferase activity	ISO Inferred from Sequence Orthology more info
enables CAAX-protein geranylgeranyltransferase activity	ISO Inferred from Sequence Orthology more info
enables CAAX-protein geranylgeranyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables heterocyclic compound binding	ISO Inferred from Sequence Orthology more info
contributes_to peptide binding	ISO Inferred from Sequence Orthology more info
enables protein geranylgeranyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein geranylgeranyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
contributes_to small molecule binding	ISO Inferred from Sequence Orthology more info
contributes_to zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in positive regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in protein geranylgeranylation	ISO Inferred from Sequence Orthology more info
involved_in protein geranylgeranylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to cytokine	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of CAAX-protein geranylgeranyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CAAX-protein geranylgeranyltransferase complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of CAAX-protein geranylgeranyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of CAAX-protein geranylgeranyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: geranylgeranyl transferase type-1 subunit beta

Names: GGTase-I-beta; geranylgeranyl transferase type I subunit beta; type I protein geranyl-geranyltransferase subunit beta

NP_001404709.1

EC 2.5.1.59

NP_001404710.1

EC 2.5.1.59

NP_001404711.1

EC 2.5.1.59

NP_001404716.1

EC 2.5.1.59

NP_001404733.1

EC 2.5.1.59

NP_766215.1

EC 2.5.1.59

XP_036017005.1

EC 2.5.1.59

XP_036017006.1

EC 2.5.1.59

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417780.1 → NP_001404709.1 geranylgeranyl transferase type-1 subunit beta isoform 2

Status: VALIDATED

Source sequence(s)

AC124717
NM_001417781.1 → NP_001404710.1 geranylgeranyl transferase type-1 subunit beta isoform 3

Status: VALIDATED

Source sequence(s)

AC124717
NM_001417782.1 → NP_001404711.1 geranylgeranyl transferase type-1 subunit beta isoform 4

Status: VALIDATED

Source sequence(s)

AC124717
NM_001417787.1 → NP_001404716.1 geranylgeranyl transferase type-1 subunit beta isoform 5

Status: VALIDATED

Source sequence(s)

AC124717
NM_001417804.1 → NP_001404733.1 geranylgeranyl transferase type-1 subunit beta isoform 6

Status: VALIDATED

Source sequence(s)

AC124717
NM_172627.4 → NP_766215.1 geranylgeranyl transferase type-1 subunit beta isoform 1

See identical proteins and their annotated locations for NP_766215.1

Status: VALIDATED

Source sequence(s)

AC124717

Consensus CDS

CCDS29230.1

UniProtKB/Swiss-Prot

Q8BUY9

Related

ENSMUSP00000158214.2, ENSMUST00000236216.2

Conserved Domains (2) summary

COG5029
Location:21 → 360

CAL1; Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism]

cd02895
Location:22 → 332

GGTase-I; Geranylgeranyltransferase types I (GGTase-I)-like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-I s are a subgroup of the protein prenyltransferase family of lipid-modifying enzymes ...

RNA

NR_184581.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC124717
NR_184582.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC124717
NR_184583.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC124717
NR_184584.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC124717
NR_184585.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC124717

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

46368411..46414173 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161113.1 → XP_036017006.1 geranylgeranyl transferase type-1 subunit beta isoform X3

Conserved Domains (1) summary

cl08267
Location:1 → 194

ISOPREN_C2_like; This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate ...
XM_036161112.1 → XP_036017005.1 geranylgeranyl transferase type-1 subunit beta isoform X1

Conserved Domains (1) summary

cd02895
Location:22 → 317

GGTase-I; Geranylgeranyltransferase types I (GGTase-I)-like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-I s are a subgroup of the protein prenyltransferase family of lipid-modifying enzymes ...