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    Sepsecs Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase [ Mus musculus (house mouse) ]

    Gene ID: 211006, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sepsecsprovided by MGI
    Official Full Name
    Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthaseprovided by MGI
    Primary source
    MGI:MGI:1098791
    See related
    Ensembl:ENSMUSG00000029173 AllianceGenome:MGI:1098791
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SLA; SecS; D5Ertd135e
    Summary
    Enables tRNA binding activity. Involved in selenocysteine incorporation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; limb; musculoskeletal system; and respiratory system. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2D. Orthologous to human SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 4.8), liver adult (RPKM 4.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sepsecs in Genome Data Viewer
    Location:
    5 C1; 5 28.44 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (52797431..52827104, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (52640089..52669764, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 8030423F21 gene Neighboring gene predicted gene, 30178 Neighboring gene STARR-seq mESC enhancer starr_13066 Neighboring gene STARR-seq mESC enhancer starr_13067 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:53060867-53061054 Neighboring gene STARR-seq mESC enhancer starr_13069 Neighboring gene phosphatidylinositol 4-kinase type 2 beta Neighboring gene zinc finger, CCHC domain containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structure and catalytic mechanism of eukaryotic selenocysteine synthase. Ganichkin OM, et al. J Biol Chem, 2008 Feb 29. PMID 18093968
    2. Identification of CD4 T-cell epitopes in soluble liver antigen/liver pancreas autoantigen in autoimmune hepatitis. Mix H, et al. Gastroenterology, 2008 Dec. PMID 18773898, Free PMC Article
    3. Missense mutation in selenocysteine synthase causes cardio-respiratory failure and perinatal death in mice which can be compensated by selenium-independent GPX4. Fradejas-Villar N, et al. Redox Biol, 2021 Nov 12. PMID 34794077, Free PMC Article
    4. Biosynthesis of selenocysteine on its tRNA in eukaryotes. Xu XM, et al. PLoS Biol, 2007 Jan. PMID 17194211, Free PMC Article
    5. Supramolecular complexes mediate selenocysteine incorporation in vivo. Small-Howard A, et al. Mol Cell Biol, 2006 Mar. PMID 16508009, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SECp43 and SLA have roles in selenoprotein synthesis [soluble liver antigen]
      Title: Evidence for direct roles of two additional factors, SECp43 and soluble liver antigen, in the selenoprotein synthesis machinery.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • 9130208G10

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables O-phosphoseryl-tRNA(Sec) selenium transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in conversion of seryl-tRNAsec to selenocys-tRNAsec IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in selenocysteine incorporation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in selenocysteine incorporation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    O-phosphoseryl-tRNA(Sec) selenium transferase
    Names
    UGA suppressor tRNA-associated protein
    selenocysteinyl-tRNA(Sec) synthase
    NP_001350392.1
    NP_766078.1
    XP_006503890.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363463.1 → NP_001350392.1  O-phosphoseryl-tRNA(Sec) selenium transferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK153792
      UniProtKB/TrEMBL
      Q3U597
      Conserved Domains (1) summary
      cl18945
      Location:1 → 317
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

    2. NM_172490.4 → NP_766078.1  O-phosphoseryl-tRNA(Sec) selenium transferase isoform 1

      See identical proteins and their annotated locations for NP_766078.1

      Status: VALIDATED

      Source sequence(s)
      AC120128
      Consensus CDS
      CCDS19286.1
      UniProtKB/Swiss-Prot
      Q6P6M7, Q8BZS6
      Related
      ENSMUSP00000031069.7, ENSMUST00000031069.13
      Conserved Domains (1) summary
      TIGR03531
      Location:13 → 458
      selenium_SpcS; O-phosphoseryl-tRNA(Sec) selenium transferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      52797431..52827104 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503827.5 → XP_006503890.1  O-phosphoseryl-tRNA(Sec) selenium transferase isoform X1

      Conserved Domains (1) summary
      cl18945
      Location:13 → 268
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P6M7.2 GenPept UniProtKB/Swiss-Prot:Q6P6M7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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