Kcnk3 potassium channel, subfamily K, member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnk3provided by MGI
Official Full Name: potassium channel, subfamily K, member 3provided by MGI
Primary source: MGI:MGI:1100509
See related: Ensembl:ENSMUSG00000049265 AllianceGenome:MGI:1100509
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TASK; Task-1; cTBAK-1
Summary: Predicted to enable S100 protein binding activity and potassium channel activity. Involved in detection of hypoxic conditions in blood by carotid body chemoreceptor signaling and regulation of action potential firing rate. Predicted to be active in plasma membrane. Is expressed in early conceptus; heart; and secondary oocyte. Human ortholog(s) of this gene implicated in primary pulmonary hypertension. Orthologous to human KCNK3 (potassium two pore domain channel subfamily K member 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in adrenal adult (RPKM 1700.1) and heart adult (RPKM 66.4) See more
Orthologs: human all
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Genomic context

Location:: 5 B1; 5 16.68 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (30745514..30782614)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (30588170..30625270)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genome-Wide Methylation Analysis Reveals a KCNK3-Prominent Causal Cascade on Hypertension.
Title: Genome-Wide Methylation Analysis Reveals a KCNK3-Prominent Causal Cascade on Hypertension.
TWIK-related acid-sensitive potassium channels TASK-1 and TASK-3 may participate in the process of the coexistence of asthma and OSA.
Title: TWIK-related acid-sensitive potassium channels TASK-1 and TASK-3 may participate in the process of the coexistence of asthma and OSA.
Expression of p11 and heteromeric TASK channels in mouse adrenal cortical cells and H295R cells.
Title: Expression of p11 and heteromeric TASK channels in mouse adrenal cortical cells and H295R cells.
KCNK3 Mutation Causes Altered Immune Function in Pulmonary Arterial Hypertension Patients and Mouse Models.
Title: KCNK3 Mutation Causes Altered Immune Function in Pulmonary Arterial Hypertension Patients and Mouse Models.
TASK-1 and TASK-3 strongly affect the development of pressure overload cardiomyopathies in genetic models of TASK-1 and TASK-3 loss of function. The effects of TASK-1 loss of function were associated with enhanced AKT phosphorylation and expression of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) transcription factor.
Title: TASK-1 and TASK-3 channels modulate pressure overload-induced cardiac remodeling and dysfunction.
Study reports that the transcription factor Sp1 controls p11 expression, which impacts on excitability by hampering functional expression of TASK1. In the SOD1-G93A mouse model of amyotrophic lateral sclerosis (ALS), Sp1-p11-TASK1 dysregulation contributes to increased excitability and vulnerability of motor neurons. Interference with either Sp1 or p11 delays neuron loss and prolongs lifespan in this model.
Title: Sp1-regulated expression of p11 contributes to motor neuron degeneration by membrane insertion of TASK1.
deleted TASK-1 and TASK-3 channels selectively from zona glomerulosa cells and generated a model of mild aldosterone autonomy with attendant hypertension that is aldosterone-driven and Ang II (angiotensin II)-independent.
Title: Adrenal Tissue-Specific Deletion of TASK Channels Causes Aldosterone-Driven Angiotensin II-Independent Hypertension.
TASK-1 channels displayed strong cardiac expression in mice. Dysregulation of atrial TASK-1 expression in murine atrial fibrillation and heart failure models suggests potential relevance of TASK-1 currents in arrhythmogenesis.
Title: Atrial fibrillation and heart failure-associated remodeling of two-pore-domain potassium (K(2P)) channels in murine disease models: focus on TASK-1.
studies demonstrate that TASK channels can limit ischemia-reperfusion damage in the cortex, and postconditioning with volatile anesthetics provides neuroprotective actions that depend, in part, on activation of TASK currents in cortical neurons.
Title: TASK channels contribute to neuroprotective action of inhalational anesthetics.
Whereas adult female TASK-1-/- mice had a virtually normal respiratory phenotype, except for an increased relaxation time, adult male TASK-1-/- mice exhibited enhanced ventilation that was mainly due to an increased tidal volume. Respiratory responses to hypercapnia and hypoxia were largely preserved. In neonatal TASK-1-/- mice, respiratory drive appeared reduced and knockout animals were more prone to experience apnea.
Title: Sex-dependent differences in the in vivo respiratory phenotype of the TASK-1 potassium channel knockout mouse.

Submit: New GeneRIF Correction See all GeneRIFs (46)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Kcnk3 (e-PCR), detects polymorphism
- UniSTS:547595

Kcnk3 (e-PCR), detects polymorphism
- UniSTS:547596

D5Jcs302 (e-PCR), detects polymorphism
- UniSTS:479311

Kcnk3 (e-PCR), detects polymorphism
- UniSTS:166226

PMC16288P1 (e-PCR)
- UniSTS:271473

PMC16288P2 (e-PCR)
- UniSTS:271474

AB013345 (e-PCR)
- UniSTS:179150

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables S100 protein binding	IEA Inferred from Electronic Annotation more info
enables S100 protein binding	ISO Inferred from Sequence Orthology more info
enables monoatomic ion channel activity	ISO Inferred from Sequence Orthology more info
enables open rectifier potassium channel activity	IEA Inferred from Electronic Annotation more info
enables open rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables outward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables outward rectifier potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables potassium ion leak channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium ion leak channel activity	ISO Inferred from Sequence Orthology more info
enables potassium ion leak channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables sodium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to acidic pH	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in cellular response to zinc ion	IEA Inferred from Electronic Annotation more info
involved_in cochlea development	IEA Inferred from Electronic Annotation more info
involved_in detection of hypoxic conditions in blood by carotid body chemoreceptor signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of action potential firing rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of resting membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of resting membrane potential	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: potassium channel subfamily K member 3

Names: TWIK-related acid-sensitive K(+) channel 1; acid-sensitive potassium channel protein TASK-1; cardiac two pore background K(+) channel; two pore K(+) channel KT3.1; two pore potassium channel KT3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.