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    Trim75 tripartite motif-containing 75 [ Mus musculus (house mouse) ]

    Gene ID: 333307, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Trim75provided by MGI
    Official Full Name
    tripartite motif-containing 75provided by MGI
    Primary source
    MGI:MGI:2685640
    See related
    Ensembl:ENSMUSG00000071089 AllianceGenome:MGI:2685640
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm794
    Summary
    Predicted to enable ubiquitin protein ligase activity. Involved in female meiosis I. Predicted to be located in spindle. Predicted to be active in cytoplasm. Orthologous to human TRIM75 (tripartite motif containing 75). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in ovary adult (RPKM 1.4) and kidney adult (RPKM 0.1) See more
    Orthologs
    human all
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    Genomic context

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    See Trim75 in Genome Data Viewer
    Location:
    8 B3.1; 8 32.48 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (65434303..65440296, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (64981651..64987644, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32507 Neighboring gene transmembrane protein 192 Neighboring gene tripartite motif-containing 60 Neighboring gene tripartite motif-containing 61 Neighboring gene STARR-seq mESC enhancer starr_21646 Neighboring gene apelin receptor early endogenous ligand

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Maternal factor Trim75 contributes to zygotic genome activation program in mouse early embryos. Hou W, et al. Mol Biol Rep, 2024 Apr 20. PMID 38643284
    2. Structural studies of the coiled-coil domain of TRIM75 reveal a tetramer architecture facilitating its E3 ligase complex. Lou X, et al. Comput Struct Biotechnol J, 2022. PMID 36147661, Free PMC Article
    3. Efficient Gene Knockdown in Mouse Oocytes through Peptide Nanoparticle-Mediated SiRNA Transfection. Jin Z, et al. PLoS One, 2016. PMID 26974323, Free PMC Article
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Maternal factor Trim75 contributes to zygotic genome activation program in mouse early embryos.
      Title: Maternal factor Trim75 contributes to zygotic genome activation program in mouse early embryos.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in female meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tripartite motif-containing protein 75

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033429.2 → NP_001028601.1  tripartite motif-containing protein 75

      Status: PROVISIONAL

      Source sequence(s)
      AK136018
      Consensus CDS
      CCDS22330.1
      UniProtKB/Swiss-Prot
      Q3UWZ0
      UniProtKB/TrEMBL
      B2RTB3
      Related
      ENSMUSP00000092932.2, ENSMUST00000095295.3
      Conserved Domains (3) summary
      smart00336
      Location:90 → 131
      BBOX; B-Box-type zinc finger
      pfam15227
      Location:16 → 56
      zf-C3HC4_4; zinc finger of C3HC4-type, RING
      cd15829
      Location:276 → 460
      SPRY_PRY_TRIM75; PRY/SPRY domain of tripartite motif-binding protein 75 (TRIM75)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      65434303..65440296 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UWZ0.1 GenPept UniProtKB/Swiss-Prot:Q3UWZ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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