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    Mcm4 minichromosome maintenance complex component 4 [ Mus musculus (house mouse) ]

    Gene ID: 17217, updated on 4-Jan-2025

    Summary

    Official Symbol
    Mcm4provided by MGI
    Official Full Name
    minichromosome maintenance complex component 4provided by MGI
    Primary source
    MGI:MGI:103199
    See related
    Ensembl:ENSMUSG00000022673 AllianceGenome:MGI:103199
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    19G; Cdc21; Mcmd4; mcdc21; mKIAA4003
    Summary
    Enables single-stranded DNA binding activity. Contributes to DNA helicase activity. Acts upstream of or within DNA unwinding involved in DNA replication. Part of MCM complex. Is expressed in several structures, including brain; future brain; limb; metanephros; and myocardium layer. Human ortholog(s) of this gene implicated in immunodeficiency 54. Orthologous to human MCM4 (minichromosome maintenance complex component 4). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in liver E14 (RPKM 36.5), liver E14.5 (RPKM 34.4) and 21 other tissues See more
    Orthologs
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    Genomic context

    See Mcm4 in Genome Data Viewer
    Location:
    16 A2; 16 10.09 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (15441761..15455264, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (15623897..15637400, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2 variant 2 Neighboring gene STARR-seq mESC enhancer starr_40211 Neighboring gene predicted gene 7748 Neighboring gene STARR-seq mESC enhancer starr_40212 Neighboring gene protein kinase, DNA activated, catalytic polypeptide Neighboring gene predicted gene, 52255 Neighboring gene STARR-seq mESC enhancer starr_40215 Neighboring gene STARR-seq mESC enhancer starr_40216 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:15863142-15863251 Neighboring gene STARR-positive B cell enhancer ABC_E5527 Neighboring gene mitotic spindle organizing protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • KIAA4003

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATP-dependent H2AZ histone chaperone activity  
    enables ATP-dependent H3-H4 histone complex chaperone activity  
    enables DNA clamp loader activity  
    contributes_to DNA helicase activity PubMed 
    contributes_to DNA helicase activity PubMed 
    contributes_to DNA helicase activity  
    contributes_to DNA helicase activity  
    enables chromatin extrusion motor activity  
    enables cohesin loader activity  
    enables double-stranded DNA helicase activity  
    enables forked DNA-dependent helicase activity  
    enables four-way junction helicase activity  
    enables protein binding PubMed 
    enables single-stranded 3'-5' DNA helicase activity  
    contributes_to single-stranded DNA binding PubMed 
    enables single-stranded DNA binding PubMed 
    contributes_to single-stranded DNA binding  
    contributes_to single-stranded DNA helicase activity  
    Component Evidence Code Pubs
    part_of CMG complex  
    part_of CMG complex  
    part_of MCM complex  
    part_of MCM complex PubMed 
    part_of MCM complex  
    part_of MCM complex  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    DNA replication licensing factor MCM4
    Names
    CDC21 homolog
    P1-CDC21
    mini chromosome maintenance deficient 4 homolog
    minichromosome maintenance deficient 4 homolog
    NP_032591.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008565.3NP_032591.3  DNA replication licensing factor MCM4

      Status: VALIDATED

      Source sequence(s)
      AK036653, AK141644, AK151499
      Consensus CDS
      CCDS27977.1
      UniProtKB/Swiss-Prot
      O89056, P49717
      UniProtKB/TrEMBL
      Q3UA65, Q542F4, Q921D5
      Related
      ENSMUSP00000023353.4, ENSMUST00000023353.4
      Conserved Domains (3) summary
      smart00350
      Location:266769
      MCM; minichromosome maintenance proteins
      pfam14551
      Location:165286
      MCM_N; MCM N-terminal domain
      cl21455
      Location:504643
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      15441761..15455264 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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