Cited1 Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cited1provided by MGI
Official Full Name: Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1provided by MGI
Primary source: MGI:MGI:108023
See related: Ensembl:ENSMUSG00000051159 AllianceGenome:MGI:108023
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Msg1
Summary: Enables chromatin binding activity. Involved in several processes, including negative regulation of osteoblast differentiation; positive regulation of macromolecule biosynthetic process; and response to type II interferon. Acts upstream of or within labyrinthine layer development; spongiotrophoblast layer development; and vasculogenesis. Located in cytosol and nucleus. Is expressed in several structures, including brain; early conceptus; embryo mesenchyme; genitourinary system; and heart. Orthologous to human CITED1 (Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in placenta adult (RPKM 119.3), mammary gland adult (RPKM 29.1) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: X D; X 45.25 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (101290984..101295787, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (102247378..102252181, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results show that Cited1 plays an important role in regulating trophoblast lineage specification through activating the bone morphogenetic protein signaling pathway.
Title: Transcription coactivator Cited1 acts as an inducer of trophoblast-like state from mouse embryonic stem cells through the activation of BMP signaling.
Dicer ablation in the early metanephric mesenchyme results in severe renal dysgenesis despite normal initial specification of nephron progenitors and ureteric bud outgrowth.
Title: Dicer function is required in the metanephric mesenchyme for early kidney development.
The data indicated that serine phosphorylation at position 79 in the 63-84 domain is associated with PKC activation, and is required for both CITED1 nuclear translocation induced by PTH
Title: Nuclear translocation of CBP/p300-interacting protein CITED1 induced by parathyroid hormone requires serine phosphorylation at position 79 in its 63-84 domain.
Loss of placental Cited1 leads to intrauterine organ growth restriction with decreased IGF-I and IGF-II expression and in IR and Igf1r signaling.
Title: Organ-specific defects in insulin-like growth factor and insulin receptor signaling in late gestational asymmetric intrauterine growth restriction in Cited1 mutant mice.
Renal medullary dysplasia in Cited1 mutant mice is a direct consequence of decreased tissue oxygenation resulting from placental insufficiency.
Title: Placental insufficiency associated with loss of Cited1 causes renal medullary dysplasia.
CITED1 negatively regulates osteoblastic differentiation in vitro and inhibits the cAMP-dependent stimulation of differentiation by intermittent PTH.
Title: CBP/p300-interacting protein CITED1 modulates parathyroid hormone regulation of osteoblastic differentiation.
These observations suggest that, in addition to an increased gene copy number and upregulation of EGR2 and CITED1, an elevated erbB2 transcript level involves the loss of 14-3-3sigma, which sequesters a key transcriptional regulator of the erbB2 promoter.
Title: An EGR2/CITED1 transcription factor complex and the 14-3-3sigma tumor suppressor are involved in regulating ErbB2 expression in a transgenic-mouse model of human breast cancer.
The expression pattern of Cited2 overlaps that of Cited1, but its deletion, either alone or in combination with Cited1, does not disrupt epithelial differentiation of the metanephric mesenchyme.
Title: Cited1 and Cited2 are differentially expressed in the developing kidney but are not required for nephrogenesis.
CBP inactivation in mouse thymocytes leads to lymphoma
Title: Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency.
role for CITED1 in the modulation of transcriptional events mediated by steroid hormone and cytokine signaling pathways
Title: Expression of the transcriptional coactivator CITED1 in the adult and developing murine brain.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136530 (e-PCR)
- UniSTS:210512

PMC303371P1 (e-PCR)
- UniSTS:272517

NoName (e-PCR)
- UniSTS:548512

RH136132 (e-PCR)
- UniSTS:210127

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables LBD domain binding	IEA Inferred from Electronic Annotation more info
enables LBD domain binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables co-SMAD binding	IEA Inferred from Electronic Annotation more info
enables co-SMAD binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in SMAD protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in brain development	IEP Inferred from Expression Pattern more info	PubMed
NOT involved_in branching involved in ureteric bud morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic axis specification	ISO Inferred from Sequence Orthology more info
NOT involved_in kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within labyrinthine layer development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in melanin biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in melanocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in melanocyte differentiation	IEP Inferred from Expression Pattern more info	PubMed
NOT involved_in morphogenesis of an epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleocytoplasmic transport	ISO Inferred from Sequence Orthology more info
involved_in nucleocytoplasmic transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in pigmentation	IDA Inferred from Direct Assay more info	PubMed
involved_in pigmentation	IEP Inferred from Expression Pattern more info	PubMed
involved_in placenta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in response to cAMP	IDA Inferred from Direct Assay more info	PubMed
involved_in response to cytokine	IDA Inferred from Direct Assay more info	PubMed
involved_in response to estrogen	IEA Inferred from Electronic Annotation more info
involved_in response to estrogen	ISO Inferred from Sequence Orthology more info
involved_in response to insulin	IDA Inferred from Direct Assay more info	PubMed
involved_in response to interleukin-1	IDA Inferred from Direct Assay more info	PubMed
involved_in response to interleukin-11	IDA Inferred from Direct Assay more info	PubMed
involved_in response to interleukin-2	IDA Inferred from Direct Assay more info	PubMed
involved_in response to interleukin-4	IDA Inferred from Direct Assay more info	PubMed
involved_in response to interleukin-6	IDA Inferred from Direct Assay more info	PubMed
involved_in response to interleukin-9	IDA Inferred from Direct Assay more info	PubMed
involved_in response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in response to parathyroid hormone	IDA Inferred from Direct Assay more info	PubMed
involved_in response to transforming growth factor beta	ISO Inferred from Sequence Orthology more info
involved_in response to transforming growth factor beta	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within spongiotrophoblast layer development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cbp/p300-interacting transactivator 1

Names: melanocyte-specific protein 1

NP_001263395.1

EC 3.5.1.98

NP_001263402.1

EC 3.5.1.98

NP_001263403.1

EC 3.5.1.98

NP_031735.1

EC 3.5.1.98

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001276466.1 → NP_001263395.1 cbp/p300-interacting transactivator 1 isoform a

See identical proteins and their annotated locations for NP_001263395.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same isoform (a).

Source sequence(s)

AK148042, AL954850

Consensus CDS

CCDS30322.1

UniProtKB/Swiss-Prot

P97769

UniProtKB/TrEMBL

Q3UGA1

Related

ENSMUSP00000051789.4, ENSMUST00000050551.10

Conserved Domains (1) summary

pfam04487
Location:89 → 199

CITED; CITED
NM_001276473.1 → NP_001263402.1 cbp/p300-interacting transactivator 1 isoform a

See identical proteins and their annotated locations for NP_001263402.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same isoform (a).

Source sequence(s)

AK148042, AL954850

Consensus CDS

CCDS30322.1

UniProtKB/Swiss-Prot

P97769

UniProtKB/TrEMBL

Q3UGA1

Conserved Domains (1) summary

pfam04487
Location:89 → 199

CITED; CITED
NM_001276474.1 → NP_001263403.1 cbp/p300-interacting transactivator 1 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is longer than isoform a.

Source sequence(s)

AK148042, AL954850, BC052030, CX237826

UniProtKB/Swiss-Prot

P97769

UniProtKB/TrEMBL

Q3UGA1

Conserved Domains (1) summary

pfam04487
Location:117 → 227

CITED
NM_007709.4 → NP_031735.1 cbp/p300-interacting transactivator 1 isoform a

See identical proteins and their annotated locations for NP_031735.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same isoform (a).

Source sequence(s)

AL954850, BC052030, BQ173936

Consensus CDS

CCDS30322.1

UniProtKB/Swiss-Prot

P97769

UniProtKB/TrEMBL

Q3UGA1

Related

ENSMUSP00000098890.4, ENSMUST00000101336.10

Conserved Domains (1) summary

pfam04487
Location:89 → 199

CITED; CITED