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    TRIM66 tripartite motif containing 66 [ Homo sapiens (human) ]

    Gene ID: 9866, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TRIM66provided by HGNC
    Official Full Name
    tripartite motif containing 66provided by HGNC
    Primary source
    HGNC:HGNC:29005
    See related
    Ensembl:ENSG00000166436 MIM:612000; AllianceGenome:HGNC:29005
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TIF1D; C11orf29; TIF1DELTA
    Summary
    Predicted to enable chromatin binding activity; identical protein binding activity; and zinc ion binding activity. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 4.5), skin (RPKM 3.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TRIM66 in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (8612040..8683231, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (8693787..8764985, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (8633587..8704778, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376536 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8271693-8272438 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8272439-8273182 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8281879-8282380 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8283311-8283850 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3113 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:8288990-8289574 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:8289575-8290158 Neighboring gene MPRA-validated peak1191 silencer Neighboring gene LIM domain only 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8303849-8304410 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:8304411-8304972 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8339910-8340410 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:8347375-8347960 Neighboring gene Sharpr-MPRA regulatory region 11418 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8358075-8358892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8359711-8360526 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8360626-8361287 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4383 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8373273-8373772 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4384 Neighboring gene serine/threonine kinase 33 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4385 Neighboring gene small Cajal body-specific RNA 20 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4386 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3114 Neighboring gene NANOG hESC enhancer GRCh37_chr11:8625413-8625914 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:8692389-8692996 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:8703769-8704968 Neighboring gene small nucleolar RNA, H/ACA box 3A Neighboring gene small nucleolar RNA, H/ACA box 3B Neighboring gene ribosomal protein L27a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. TRIM66 overexpresssion contributes to osteosarcoma carcinogenesis and indicates poor survival outcome. Chen Y, et al. Oncotarget, 2015 Sep 15. PMID 26247633, Free PMC Article
    2. TRIM66 Promotes Malignant Progression of Non-Small-Cell Lung Cancer Cells via Targeting MMP9. Xu Y, et al. Comput Math Methods Med, 2022. PMID 35912155, Free PMC Article
    3. TRIM66 expression in non-small cell lung cancer: A new predictor of prognosis. Ma Y, et al. Cancer Biomark, 2017 Sep 7. PMID 28946563
    4. Knockdown of TRIM66 in MDA-MB-468 triple negative breast cancer cell line suppresses proliferation and promotes apoptosis through EGFR signaling. Zhang H, et al. Pol J Pathol, 2021. PMID 34706523
    5. Knockdown of TRIM66 inhibits malignant behavior and epithelial-mesenchymal transition in non-small cell lung cancer. Dai HY, et al. Pathol Res Pract, 2018 Aug. PMID 29929749

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Circ-SATB2 (hsa_circ_0008928) and miR-150-5p are regulators of TRIM66 in the regulation of NSCLC cell growth and metastasis of NSCLC cells via the ceRNA pathway.
      Title: Circ-SATB2 (hsa_circ_0008928) and miR-150-5p are regulators of TRIM66 in the regulation of NSCLC cell growth and metastasis of NSCLC cells via the ceRNA pathway.
    2. TRIM66 Promotes Malignant Progression of Non-Small-Cell Lung Cancer Cells via Targeting MMP9.
      Title: TRIM66 Promotes Malignant Progression of Non-Small-Cell Lung Cancer Cells via Targeting MMP9.
    3. TRIM66 hastens the malignant progression of non-small cell lung cancer via modulating MMP9-mediated TGF-beta/SMAD pathway.
      Title: TRIM66 hastens the malignant progression of non-small cell lung cancer via modulating MMP9-mediated TGF-β/SMAD pathway.
    4. Association of the SNP rs112369934 near TRIM66 Gene with POAG Endophenotypes in African Americans.
      Title: Association of the SNP rs112369934 near TRIM66 Gene with POAG Endophenotypes in African Americans.
    5. Zhoushi Qi Ling decoction represses docetaxel resistance and glycolysis of castration-resistant prostate cancer via regulation of SNHG10/miR-1271-5p/TRIM66 axis.
      Title: Zhoushi Qi Ling decoction represses docetaxel resistance and glycolysis of castration-resistant prostate cancer via regulation of SNHG10/miR-1271-5p/TRIM66 axis.
    6. Knockdown of TRIM66 in MDA-MB-468 triple negative breast cancer cell line suppresses proliferation and promotes apoptosis through EGFR signaling.
      Title: Knockdown of TRIM66 in MDA-MB-468 triple negative breast cancer cell line suppresses proliferation and promotes apoptosis through EGFR signaling.
    7. TRIM66 promotes malignant progression of prostate carcinoma through the JAK/STAT pathway.
      Title: TRIM66 promotes malignant progression of prostate carcinoma through the JAK/STAT pathway.
    8. TRIM66 recruits Sirt6 to deacetylate H3K56ac, negatively regulating the level of H3K56ac and facilitating the initiation of DNA damage repair. Importantly, Trim66-deficient blastocysts also exhibit higher levels of H3K56ac and DNA damage.
      Title: TRIM66 reads unmodified H3R2K4 and H3K56ac to respond to DNA damage in embryonic stem cells.
    9. High TRIM66 expression is associated with cell proliferation, migration and invasion in colorectal cancer through JAK2/STAT3 pathway.
      Title: Knockdown of TRIM66 inhibits cell proliferation, migration and invasion in colorectal cancer through JAK2/STAT3 pathway.
    10. TRIM66 functioned as an oncogenic protein in HCC by promoting the activation of Wnt/beta-catenin signaling
      Title: TRIM66 confers tumorigenicity of hepatocellular carcinoma cells by regulating GSK-3β-dependent Wnt/β-catenin signaling.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
    EBI GWAS Catalog
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    EBI GWAS Catalog
    Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of tripartite motif containing 66 (TRIM66) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10046

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tripartite motif-containing protein 66
    Names
    transcriptional intermediary factor 1 delta

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001388022.1 → NP_001374951.1  tripartite motif-containing protein 66 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC091053, AC104360
      Consensus CDS
      CCDS91432.1
      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4
      UniProtKB/TrEMBL
      A0A8Z5E822
      Related
      ENSP00000495413.1, ENST00000646038.2
      Conserved Domains (5) summary
      cd05502
      Location:1218 → 1326
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:253 → 378
      BBC; B-Box C-terminal domain
      cd19794
      Location:208 → 250
      Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cd19811
      Location:149 → 185
      Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cl22851
      Location:1145 → 1193
      PHD_SF; PHD finger superfamily

    2. NM_001388023.1 → NP_001374952.1  tripartite motif-containing protein 66 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC091053, AC104360
      Consensus CDS
      CCDS91433.1
      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4
      UniProtKB/TrEMBL
      A0A994J572
      Related
      ENSP00000516162.1, ENST00000705689.1
      Conserved Domains (5) summary
      cd05502
      Location:1181 → 1289
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:216 → 341
      BBC; B-Box C-terminal domain
      cd19794
      Location:171 → 213
      Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cd19811
      Location:112 → 148
      Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cl22851
      Location:1108 → 1156
      PHD_SF; PHD finger superfamily

    3. NM_001388024.1 → NP_001374953.1  tripartite motif-containing protein 66 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC091053, AC104360
      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4
      Conserved Domains (6) summary
      cd05502
      Location:1190 → 1298
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:253 → 378
      BBC; B-Box C-terminal domain
      TIGR00601
      Location:710 → 909
      rad23; UV excision repair protein Rad23
      cd19794
      Location:208 → 250
      Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cd19811
      Location:149 → 185
      Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cl22851
      Location:1117 → 1165
      PHD_SF; PHD finger superfamily

    4. NM_014818.2 → NP_055633.1  tripartite motif-containing protein 66 isoform 1

      See identical proteins and their annotated locations for NP_055633.1

      Status: VALIDATED

      Source sequence(s)
      AC091053, AC104360
      UniProtKB/TrEMBL
      A0A994J5L5
      Conserved Domains (4) summary
      cd05502
      Location:1042 → 1150
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:108 → 233
      BBC; B-Box C-terminal domain
      cd00021
      Location:64 → 99
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cl22851
      Location:969 → 1017
      PHD_SF; PHD finger superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      8612040..8683231 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017018629.2 → XP_016874118.1  tripartite motif-containing protein 66 isoform X1

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4
      UniProtKB/TrEMBL
      A0A8Z5E822
      Conserved Domains (5) summary
      cd05502
      Location:1218 → 1326
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:253 → 378
      BBC; B-Box C-terminal domain
      cd19794
      Location:208 → 250
      Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cd19811
      Location:149 → 185
      Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cl22851
      Location:1145 → 1193
      PHD_SF; PHD finger superfamily

    2. XM_047427941.1 → XP_047283897.1  tripartite motif-containing protein 66 isoform X4

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4

    3. XM_011520507.4 → XP_011518809.1  tripartite motif-containing protein 66 isoform X1

      See identical proteins and their annotated locations for XP_011518809.1

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4
      UniProtKB/TrEMBL
      A0A8Z5E822
      Conserved Domains (5) summary
      cd05502
      Location:1218 → 1326
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:253 → 378
      BBC; B-Box C-terminal domain
      cd19794
      Location:208 → 250
      Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cd19811
      Location:149 → 185
      Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cl22851
      Location:1145 → 1193
      PHD_SF; PHD finger superfamily

    4. XM_047427943.1 → XP_047283899.1  tripartite motif-containing protein 66 isoform X6

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4

    5. XM_011520510.2 → XP_011518812.1  tripartite motif-containing protein 66 isoform X4

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4
      Conserved Domains (6) summary
      cd05502
      Location:1190 → 1298
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:253 → 378
      BBC; B-Box C-terminal domain
      TIGR00601
      Location:710 → 909
      rad23; UV excision repair protein Rad23
      cd19794
      Location:208 → 250
      Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cd19811
      Location:149 → 185
      Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cl22851
      Location:1117 → 1165
      PHD_SF; PHD finger superfamily

    6. XM_011520509.2 → XP_011518811.1  tripartite motif-containing protein 66 isoform X3

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4
      Conserved Domains (4) summary
      smart00502
      Location:253 → 378
      BBC; B-Box C-terminal domain
      cd00021
      Location:209 → 244
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cl02556
      Location:1225 → 1301
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
      cl22851
      Location:1145 → 1193
      PHD_SF; PHD finger superfamily

    7. XM_011520508.3 → XP_011518810.1  tripartite motif-containing protein 66 isoform X2

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4
      Conserved Domains (6) summary
      cd05502
      Location:1218 → 1326
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:253 → 378
      BBC; B-Box C-terminal domain
      pfam05109
      Location:722 → 894
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd19794
      Location:208 → 250
      Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cd19811
      Location:149 → 185
      Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cl22851
      Location:1145 → 1193
      PHD_SF; PHD finger superfamily

    8. XM_047427944.1 → XP_047283900.1  tripartite motif-containing protein 66 isoform X6

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4

    9. XM_047427942.1 → XP_047283898.1  tripartite motif-containing protein 66 isoform X5

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4
      UniProtKB/TrEMBL
      A0A994J572

    10. XM_047427940.1 → XP_047283896.1  tripartite motif-containing protein 66 isoform X4

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4

    11. XM_011520504.1 → XP_011518806.1  tripartite motif-containing protein 66 isoform X1

      See identical proteins and their annotated locations for XP_011518806.1

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4
      UniProtKB/TrEMBL
      A0A8Z5E822
      Conserved Domains (5) summary
      cd05502
      Location:1218 → 1326
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:253 → 378
      BBC; B-Box C-terminal domain
      cd19794
      Location:208 → 250
      Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cd19811
      Location:149 → 185
      Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cl22851
      Location:1145 → 1193
      PHD_SF; PHD finger superfamily

    12. XM_011520516.1 → XP_011518818.1  tripartite motif-containing protein 66 isoform X9

      See identical proteins and their annotated locations for XP_011518818.1

      UniProtKB/TrEMBL
      A0A994J5L5, A0A994J7V7
      Conserved Domains (4) summary
      cd05502
      Location:1073 → 1181
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:108 → 233
      BBC; B-Box C-terminal domain
      cd00021
      Location:64 → 99
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cl22851
      Location:1000 → 1048
      PHD_SF; PHD finger superfamily

    13. XM_011520519.1 → XP_011518821.1  tripartite motif-containing protein 66 isoform X9

      See identical proteins and their annotated locations for XP_011518821.1

      UniProtKB/TrEMBL
      A0A994J5L5, A0A994J7V7
      Conserved Domains (4) summary
      cd05502
      Location:1073 → 1181
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:108 → 233
      BBC; B-Box C-terminal domain
      cd00021
      Location:64 → 99
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cl22851
      Location:1000 → 1048
      PHD_SF; PHD finger superfamily

    14. XM_011520513.1 → XP_011518815.1  tripartite motif-containing protein 66 isoform X7

      See identical proteins and their annotated locations for XP_011518815.1

      UniProtKB/TrEMBL
      A0A994J5L5
      Conserved Domains (4) summary
      cd05502
      Location:1132 → 1240
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:167 → 292
      BBC; B-Box C-terminal domain
      cd00021
      Location:123 → 158
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cl22851
      Location:1059 → 1107
      PHD_SF; PHD finger superfamily

    15. XM_011520512.1 → XP_011518814.1  tripartite motif-containing protein 66 isoform X7

      See identical proteins and their annotated locations for XP_011518814.1

      UniProtKB/TrEMBL
      A0A994J5L5
      Conserved Domains (4) summary
      cd05502
      Location:1132 → 1240
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:167 → 292
      BBC; B-Box C-terminal domain
      cd00021
      Location:123 → 158
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cl22851
      Location:1059 → 1107
      PHD_SF; PHD finger superfamily

    16. XM_047427945.1 → XP_047283901.1  tripartite motif-containing protein 66 isoform X8

      UniProtKB/TrEMBL
      A0A994J5L5

    17. XM_011520514.3 → XP_011518816.1  tripartite motif-containing protein 66 isoform X7

      See identical proteins and their annotated locations for XP_011518816.1

      UniProtKB/TrEMBL
      A0A994J5L5
      Conserved Domains (4) summary
      cd05502
      Location:1132 → 1240
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:167 → 292
      BBC; B-Box C-terminal domain
      cd00021
      Location:123 → 158
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cl22851
      Location:1059 → 1107
      PHD_SF; PHD finger superfamily

    18. XM_047427946.1 → XP_047283902.1  tripartite motif-containing protein 66 isoform X9

      UniProtKB/TrEMBL
      A0A994J5L5, A0A994J7V7

    19. XM_011520515.1 → XP_011518817.1  tripartite motif-containing protein 66 isoform X9

      See identical proteins and their annotated locations for XP_011518817.1

      UniProtKB/TrEMBL
      A0A994J5L5, A0A994J7V7
      Conserved Domains (4) summary
      cd05502
      Location:1073 → 1181
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:108 → 233
      BBC; B-Box C-terminal domain
      cd00021
      Location:64 → 99
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cl22851
      Location:1000 → 1048
      PHD_SF; PHD finger superfamily

    20. XM_011520522.3 → XP_011518824.1  tripartite motif-containing protein 66 isoform X9

      See identical proteins and their annotated locations for XP_011518824.1

      UniProtKB/TrEMBL
      A0A994J5L5, A0A994J7V7
      Related
      ENSP00000516163.1, ENST00000705690.1
      Conserved Domains (4) summary
      cd05502
      Location:1073 → 1181
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:108 → 233
      BBC; B-Box C-terminal domain
      cd00021
      Location:64 → 99
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cl22851
      Location:1000 → 1048
      PHD_SF; PHD finger superfamily

    21. XM_006718398.4 → XP_006718461.1  tripartite motif-containing protein 66 isoform X9

      See identical proteins and their annotated locations for XP_006718461.1

      UniProtKB/TrEMBL
      A0A994J5L5, A0A994J7V7
      Conserved Domains (4) summary
      cd05502
      Location:1073 → 1181
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:108 → 233
      BBC; B-Box C-terminal domain
      cd00021
      Location:64 → 99
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cl22851
      Location:1000 → 1048
      PHD_SF; PHD finger superfamily

    22. XM_011520517.3 → XP_011518819.1  tripartite motif-containing protein 66 isoform X9

      See identical proteins and their annotated locations for XP_011518819.1

      UniProtKB/TrEMBL
      A0A994J5L5, A0A994J7V7
      Conserved Domains (4) summary
      cd05502
      Location:1073 → 1181
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:108 → 233
      BBC; B-Box C-terminal domain
      cd00021
      Location:64 → 99
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cl22851
      Location:1000 → 1048
      PHD_SF; PHD finger superfamily

    23. XM_017018631.1 → XP_016874120.1  tripartite motif-containing protein 66 isoform X9

      UniProtKB/TrEMBL
      A0A994J5L5, A0A994J7V7
      Conserved Domains (4) summary
      cd05502
      Location:1073 → 1181
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:108 → 233
      BBC; B-Box C-terminal domain
      cd00021
      Location:64 → 99
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cl22851
      Location:1000 → 1048
      PHD_SF; PHD finger superfamily

    24. XM_047427947.1 → XP_047283903.1  tripartite motif-containing protein 66 isoform X10

      UniProtKB/TrEMBL
      A0A994J5L5

    25. XM_011520527.2 → XP_011518829.1  tripartite motif-containing protein 66 isoform X15

      Conserved Domains (2) summary
      cd05502
      Location:569 → 677
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      cd15625
      Location:496 → 544
      PHD_TIF1delta; PHD finger found in transcriptional intermediary factor 1 delta (TIF1delta)

    26. XM_047427948.1 → XP_047283904.1  tripartite motif-containing protein 66 isoform X14

    27. XM_011520526.3 → XP_011518828.1  tripartite motif-containing protein 66 isoform X13

      Conserved Domains (2) summary
      cd05502
      Location:827 → 935
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      cd15625
      Location:754 → 802
      PHD_TIF1delta; PHD finger found in transcriptional intermediary factor 1 delta (TIF1delta)

    28. XM_011520524.2 → XP_011518826.1  tripartite motif-containing protein 66 isoform X11

      Conserved Domains (2) summary
      smart00502
      Location:253 → 378
      BBC; B-Box C-terminal domain
      cd00021
      Location:209 → 244
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

    29. XM_011520525.2 → XP_011518827.1  tripartite motif-containing protein 66 isoform X12

      Conserved Domains (2) summary
      smart00502
      Location:253 → 378
      BBC; B-Box C-terminal domain
      cd00021
      Location:209 → 244
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

    RNA

    1. XR_930930.2 RNA Sequence

    2. XR_930929.2 RNA Sequence

    3. XR_930931.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      8693787..8764985 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054370650.1 → XP_054226625.1  tripartite motif-containing protein 66 isoform X1

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4

    2. XM_054370655.1 → XP_054226630.1  tripartite motif-containing protein 66 isoform X4

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4

    3. XM_054370649.1 → XP_054226624.1  tripartite motif-containing protein 66 isoform X1

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4

    4. XM_054370657.1 → XP_054226632.1  tripartite motif-containing protein 66 isoform X6

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4

    5. XM_054370653.1 → XP_054226628.1  tripartite motif-containing protein 66 isoform X4

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4

    6. XM_054370652.1 → XP_054226627.1  tripartite motif-containing protein 66 isoform X3

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4

    7. XM_054370651.1 → XP_054226626.1  tripartite motif-containing protein 66 isoform X2

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4

    8. XM_054370658.1 → XP_054226633.1  tripartite motif-containing protein 66 isoform X6

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4

    9. XM_054370656.1 → XP_054226631.1  tripartite motif-containing protein 66 isoform X5

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4

    10. XM_054370654.1 → XP_054226629.1  tripartite motif-containing protein 66 isoform X4

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4

    11. XM_054370648.1 → XP_054226623.1  tripartite motif-containing protein 66 isoform X1

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4

    12. XM_054370664.1 → XP_054226639.1  tripartite motif-containing protein 66 isoform X9

      UniProtKB/TrEMBL
      A0A994J5L5

    13. XM_054370667.1 → XP_054226642.1  tripartite motif-containing protein 66 isoform X9

      UniProtKB/TrEMBL
      A0A994J5L5

    14. XM_054370661.1 → XP_054226636.1  tripartite motif-containing protein 66 isoform X7

      UniProtKB/TrEMBL
      A0A994J5L5

    15. XM_054370660.1 → XP_054226635.1  tripartite motif-containing protein 66 isoform X7

      UniProtKB/TrEMBL
      A0A994J5L5

    16. XM_054370662.1 → XP_054226637.1  tripartite motif-containing protein 66 isoform X8

      UniProtKB/TrEMBL
      A0A994J5L5

    17. XM_054370659.1 → XP_054226634.1  tripartite motif-containing protein 66 isoform X7

      UniProtKB/TrEMBL
      A0A994J5L5

    18. XM_054370668.1 → XP_054226643.1  tripartite motif-containing protein 66 isoform X9

      UniProtKB/TrEMBL
      A0A994J5L5

    19. XM_054370663.1 → XP_054226638.1  tripartite motif-containing protein 66 isoform X9

      UniProtKB/TrEMBL
      A0A994J5L5

    20. XM_054370670.1 → XP_054226645.1  tripartite motif-containing protein 66 isoform X9

      UniProtKB/TrEMBL
      A0A994J5L5

    21. XM_054370666.1 → XP_054226641.1  tripartite motif-containing protein 66 isoform X9

      UniProtKB/TrEMBL
      A0A994J5L5

    22. XM_054370665.1 → XP_054226640.1  tripartite motif-containing protein 66 isoform X9

      UniProtKB/TrEMBL
      A0A994J5L5

    23. XM_054370669.1 → XP_054226644.1  tripartite motif-containing protein 66 isoform X9

      UniProtKB/TrEMBL
      A0A994J5L5

    24. XM_054370671.1 → XP_054226646.1  tripartite motif-containing protein 66 isoform X10

      UniProtKB/TrEMBL
      A0A994J5L5

    25. XM_054370676.1 → XP_054226651.1  tripartite motif-containing protein 66 isoform X15

    26. XM_054370675.1 → XP_054226650.1  tripartite motif-containing protein 66 isoform X14

    27. XM_054370674.1 → XP_054226649.1  tripartite motif-containing protein 66 isoform X13

    28. XM_054370672.1 → XP_054226647.1  tripartite motif-containing protein 66 isoform X11

    29. XM_054370673.1 → XP_054226648.1  tripartite motif-containing protein 66 isoform X12

    RNA

    1. XR_008488499.1 RNA Sequence

    2. XR_008488498.1 RNA Sequence

    3. XR_008488500.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O15016.5 GenPept UniProtKB/Swiss-Prot:O15016

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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