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    Stk35 serine/threonine kinase 35 [ Mus musculus (house mouse) ]

    Gene ID: 67333, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Stk35provided by MGI
    Official Full Name
    serine/threonine kinase 35provided by MGI
    Primary source
    MGI:MGI:1914583
    See related
    Ensembl:ENSMUSG00000037885 AllianceGenome:MGI:1914583
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CLIK1; Stk35l1; 1700054C12Rik
    Summary
    Predicted to enable eukaryotic translation initiation factor 2alpha kinase activity. Predicted to be involved in regulation of translational initiation. Predicted to be located in nuclear body. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including bone; cerebellum; gonad; pelvic girdle skeleton; and sensory organ. Orthologous to human STK35 (serine/threonine kinase 35). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 34.5), ovary adult (RPKM 13.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Stk35 in Genome Data Viewer
    Location:
    2 F1; 2 63.19 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (129642437..129674207)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (129800517..129832287)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05677 Neighboring gene prodynorphin Neighboring gene STARR-seq mESC enhancer starr_05678 Neighboring gene STARR-seq mESC enhancer starr_05679 Neighboring gene peptidylprolyl isomerase A (Ppia) pseudogene 2_1620.1 Neighboring gene STARR-seq mESC enhancer starr_05680 Neighboring gene STARR-seq mESC enhancer starr_05681 Neighboring gene STARR-seq mESC enhancer starr_05682 Neighboring gene serine/threonine kinase 35, opposite strand 1 Neighboring gene STARR-seq mESC enhancer starr_05684 Neighboring gene predicted gene, 39933 Neighboring gene STARR-seq mESC enhancer starr_05686 Neighboring gene transglutaminase 3, E polypeptide Neighboring gene predicted gene, 52561

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Nuclear retention of importin α coordinates cell fate through changes in gene expression. Yasuda Y, et al. EMBO J, 2012 Jan 4. PMID 21964068, Free PMC Article
    2. The STK35 locus contributes to normal gametogenesis and encodes a lncRNA responsive to oxidative stress. Miyamoto Y, et al. Biol Open, 2018 Aug 6. PMID 29970477, Free PMC Article
    3. Identifying and characterizing a novel protein kinase STK35L1 and deciphering its orthologs and close-homologs in vertebrates. Goyal P, et al. PLoS One, 2009 Sep 16. PMID 19756140, Free PMC Article
    4. High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles M, et al. Science, 2005 Mar 11. PMID 15761153
    5. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of G2/MI transition of meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 35
    Names
    CLP-36 interacting kinase
    serine/threonine-protein kinase 35 L1
    NP_001033724.2
    NP_899085.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038635.2 → NP_001033724.2  serine/threonine-protein kinase 35 isoform b

      Status: VALIDATED

      Source sequence(s)
      AI431080, AK085193, AL808137
      Consensus CDS
      CCDS16731.2
      UniProtKB/TrEMBL
      E9PXA2
      Related
      ENSMUSP00000132862.3, ENSMUST00000166282.3
      Conserved Domains (1) summary
      cl21453
      Location:206 → 304
      PKc_like; Protein Kinases, catalytic domain

    2. NM_183262.3 → NP_899085.3  serine/threonine-protein kinase 35 isoform a

      See identical proteins and their annotated locations for NP_899085.3

      Status: VALIDATED

      Source sequence(s)
      AI431080, AK006778, AK085193, AL808137, BC047277
      Consensus CDS
      CCDS16732.2
      UniProtKB/Swiss-Prot
      A2ANF2, Q3TMD8, Q80ZW0, Q8BIC2
      Related
      ENSMUSP00000126541.3, ENSMUST00000165413.9
      Conserved Domains (2) summary
      smart00220
      Location:207 → 528
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13977
      Location:206 → 534
      STKc_PDIK1L; Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      129642437..129674207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80ZW0.3 GenPept UniProtKB/Swiss-Prot:Q80ZW0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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