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    SYNGR2 synaptogyrin 2 [ Homo sapiens (human) ]

    Gene ID: 9144, updated on 10-Dec-2024

    Summary

    Official Symbol
    SYNGR2provided by HGNC
    Official Full Name
    synaptogyrin 2provided by HGNC
    Primary source
    HGNC:HGNC:11499
    See related
    Ensembl:ENSG00000108639 MIM:603926; AllianceGenome:HGNC:11499
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes an integral membrane protein containing four transmembrane regions and a C-terminal cytoplasmic tail that is tyrosine phosphorylated. The exact function of this protein is unclear, but studies of a similar rat protein suggest that it may play a role in regulating membrane traffic in non-neuronal cells. The gene belongs to the synaptogyrin gene family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
    Expression
    Ubiquitous expression in prostate (RPKM 65.0), lung (RPKM 62.5) and 25 other tissues See more
    Orthologs
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    Genomic context

    See SYNGR2 in Genome Data Viewer
    Location:
    17q25.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (78168545..78172964)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (79062641..79067058)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (76164626..76169045)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene transmembrane channel like 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12859 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9043 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9044 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76129823-76130348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76130349-76130874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76133293-76133934 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12863 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12865 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76135219-76135858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9045 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:76137495-76138694 Neighboring gene transmembrane channel like 8 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9046 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12867 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76144923-76145422 Neighboring gene chromosome 17 open reading frame 99 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76147835-76148412 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76148413-76148989 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9047 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12868 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76154005-76154506 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12869 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12870 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9048 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9049 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76160142-76160642 Neighboring gene eukaryotic translation initiation factor 5A pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9050 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12871 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12872 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12873 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12874 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12875 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12876 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12877 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76171843-76172621 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76172622-76173399 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76180346-76181247 Neighboring gene thymidine kinase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9052 Neighboring gene arylformamidase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12879

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    Interactions

    General gene information

    Clone Names

    • MGC102914

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in regulated exocytosis  
    involved_in synaptic vesicle membrane organization  
    Component Evidence Code Pubs
    located_in extracellular exosome PubMed 
    located_in lipid droplet  
    located_in membrane PubMed 
    is_active_in neuromuscular junction  
    is_active_in synaptic vesicle membrane  
    located_in synaptic vesicle membrane  

    General protein information

    Preferred Names
    synaptogyrin-2
    Names
    cellugyrin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320523.2 → NP_001307452.1  synaptogyrin-2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC021593, BC105992, BI160076, CF122406
      UniProtKB/TrEMBL
      K7ELS8
      Related
      ENSP00000466204.1, ENST00000589168.1
      Conserved Domains (1) summary
      pfam01284
      Location:20 → 117
      MARVEL; Membrane-associating domain
    2. NM_001363778.1 → NP_001350707.1  synaptogyrin-2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC021593, BC105992
      Consensus CDS
      CCDS86641.1
      Related
      ENSP00000467600.1, ENST00000588282.5
      Conserved Domains (1) summary
      pfam01284
      Location:20 → 161
      MARVEL; Membrane-associating domain
    3. NM_004710.7 → NP_004701.1  synaptogyrin-2 isoform 1

      See identical proteins and their annotated locations for NP_004701.1

      Status: REVIEWED

      Source sequence(s)
      AC021593
      Consensus CDS
      CCDS11753.1
      UniProtKB/Swiss-Prot
      A8MWL6, O43760, O43762, Q3KQZ2, Q658S7
      Related
      ENSP00000225777.2, ENST00000225777.8
      Conserved Domains (1) summary
      pfam01284
      Location:20 → 165
      MARVEL; Membrane-associating domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      78168545..78172964
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      79062641..79067058
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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