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    SPIN4 spindlin family member 4 [ Homo sapiens (human) ]

    Gene ID: 139886, updated on 9-Dec-2024

    Summary

    Official Symbol
    SPIN4provided by HGNC
    Official Full Name
    spindlin family member 4provided by HGNC
    Primary source
    HGNC:HGNC:27040
    See related
    Ensembl:ENSG00000186767 MIM:301113; AllianceGenome:HGNC:27040
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LJBS; TDRD28
    Summary
    Enables methylated histone binding activity. Involved in negative regulation of cell population proliferation and positive regulation of canonical Wnt signaling pathway. Located in chromatin; cytoplasm; and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Genomic context

    See SPIN4 in Genome Data Viewer
    Location:
    Xq11.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (63347228..63351332, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (61772497..61776601, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (62567107..62571211, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene endogenous retrovirus group FRD member 1, envelope pseudogene Neighboring gene SPIN4 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:62550986-62551486 Neighboring gene chromobox 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20874 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29707 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29706 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29705 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:62627697-62628511 Neighboring gene long intergenic non-protein coding RNA 1278 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:62712259-62712759 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:62723770-62724270 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:62724271-62724771 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:62780155-62780696 Neighboring gene Cdc42 guanine nucleotide exchange factor 9 Neighboring gene ARHGEF9 intronic transcript 1

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ44984, MGC133224

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in gamete generation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012968.3NP_001012986.2  spindlin-4

      See identical proteins and their annotated locations for NP_001012986.2

      Status: VALIDATED

      Source sequence(s)
      AL158203
      Consensus CDS
      CCDS43964.1
      UniProtKB/Swiss-Prot
      B3KX90, Q56A73, Q5JUL2
      Related
      ENSP00000364018.3, ENST00000374884.3
      Conserved Domains (1) summary
      pfam02513
      Location:4189
      Spin-Ssty; Spin/Ssty Family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      63347228..63351332 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      61772497..61776601 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)