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    DEFB135 defensin beta 135 [ Homo sapiens (human) ]

    Gene ID: 613209, updated on 27-Nov-2024

    Summary

    Official Symbol
    DEFB135provided by HGNC
    Official Full Name
    defensin beta 135provided by HGNC
    Primary source
    HGNC:HGNC:32400
    See related
    Ensembl:ENSG00000205883 AllianceGenome:HGNC:32400
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DEFB136
    Summary
    Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 8p23. [provided by RefSeq, Nov 2014]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See DEFB135 in Genome Data Viewer
    Location:
    8p23.1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (11982256..11984590)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (7755679..7758013, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (11839765..11842099)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379244 Neighboring gene uncharacterized LOC112268017 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:11814647-11815164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:11815165-11815680 Neighboring gene defensin beta 136 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:11843909-11844409 Neighboring gene nuclear receptor binding SET domain protein 3 pseudogene Neighboring gene defensin beta 134 Neighboring gene uncharacterized LOC105379245 Neighboring gene olfactory receptor family 7 subfamily E member 160 pseudogene Neighboring gene defensin beta 131E (pseudogene)

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    beta-defensin 135
    Names
    beta-defensin 136

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033017.3NP_001028189.2  beta-defensin 135 precursor

      See identical proteins and their annotated locations for NP_001028189.2

      Status: VALIDATED

      Source sequence(s)
      AC107918
      Consensus CDS
      CCDS43710.1
      UniProtKB/Swiss-Prot
      Q30KP9, Q4QY37
      Related
      ENSP00000371643.2, ENST00000382208.3
      Conserved Domains (1) summary
      pfam13841
      Location:3665
      Defensin_beta_2; Beta defensin

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      11982256..11984590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654717.1 Reference GRCh38.p14 PATCHES

      Range
      1363428..1365762 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      7755679..7758013 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)