U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    HAUS6 HAUS augmin like complex subunit 6 [ Homo sapiens (human) ]

    Gene ID: 54801, updated on 3-Dec-2024

    Summary

    Official Symbol
    HAUS6provided by HGNC
    Official Full Name
    HAUS augmin like complex subunit 6provided by HGNC
    Primary source
    HGNC:HGNC:25948
    See related
    Ensembl:ENSG00000147874 MIM:613433; AllianceGenome:HGNC:25948
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Dgt6; FAM29A
    Summary
    The protein encoded by this gene is a subunit of the augmin complex. The augmin complex plays a role in microtubule attachment to the kinetochore and central spindle formation. This protein may have a role in efficient chromosome congression and segregation by promoting microtubule-dependent microtubule amplification. Pseudogenes of this gene are located on chromosomes 7 and 20. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
    Expression
    Broad expression in testis (RPKM 9.5), lymph node (RPKM 4.7) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See HAUS6 in Genome Data Viewer
    Location:
    9p22.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (19053141..19102904, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (19066006..19115757, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (19053139..19102902, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene stabilizer of axonemal microtubules 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:19032529-19033082 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:19033083-19033636 Neighboring gene proteasome 26S subunit, ATPase 3 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:19049365-19049886 Neighboring gene Ras related GTP binding A Neighboring gene small Cajal body-specific RNA 8 Neighboring gene RNA, U6 small nuclear 264, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:19102581-19103144 Neighboring gene Sharpr-MPRA regulatory region 12241 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:19126736-19127246 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:19127247-19127756 Neighboring gene perilipin 2 Neighboring gene CRISPRi-validated cis-regulatory element chr9.246 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28219 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:19186502-19187002 Neighboring gene ribosomal protein S6 pseudogene 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC102696, MGC138798, MGC138799

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in centrosome cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in centrosome cycle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of microtubule nucleation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spindle assembly NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of HAUS complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of HAUS complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in mitotic spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitotic spindle microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    HAUS augmin-like complex subunit 6
    Names
    dim gamma-tubulin homolog
    family with sequence similarity 29, member A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270890.2NP_001257819.1  HAUS augmin-like complex subunit 6 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
      Source sequence(s)
      AF537091, AK301852, AL356000
      UniProtKB/TrEMBL
      Q5VY60
      Conserved Domains (1) summary
      pfam14661
      Location:15239
      HAUS6_N; HAUS augmin-like complex subunit 6 N-terminus
    2. NM_017645.5NP_060115.3  HAUS augmin-like complex subunit 6 isoform 1

      See identical proteins and their annotated locations for NP_060115.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AF537091, AL356000, BC114492
      Consensus CDS
      CCDS6489.1
      UniProtKB/Swiss-Prot
      B3KPK4, B4DX82, Q05CG1, Q14CB6, Q14CD9, Q2TA91, Q6IQ10, Q6NZX5, Q7Z4H7, Q8IZQ4, Q96FN0, Q9H950, Q9H998, Q9HCJ8, Q9NXT8
      UniProtKB/TrEMBL
      Q5VY60
      Related
      ENSP00000369871.3, ENST00000380502.8
      Conserved Domains (1) summary
      pfam14661
      Location:15239
      HAUS6_N; HAUS augmin-like complex subunit 6 N-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      19053141..19102904 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423518.1XP_047279474.1  HAUS augmin-like complex subunit 6 isoform X2

      UniProtKB/TrEMBL
      Q5VY60
      Related
      ENSP00000369865.1, ENST00000380496.5
    2. XM_011517935.3XP_011516237.1  HAUS augmin-like complex subunit 6 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      19066006..19115757 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363132.1XP_054219107.1  HAUS augmin-like complex subunit 6 isoform X1