DDR1 discoidin domain receptor tyrosine kinase 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: DDR1provided by HGNC
Official Full Name: discoidin domain receptor tyrosine kinase 1provided by HGNC
Primary source: HGNC:HGNC:2730
See related: Ensembl:ENSG00000204580 MIM:600408; AllianceGenome:HGNC:2730
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CAK; DDR; NEP; HGK2; PTK3; RTK6; TRKE; CD167; EDDR1; MCK10; NTRK4; PTK3A
Summary: Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Expression: Ubiquitous expression in brain (RPKM 49.5), thyroid (RPKM 24.8) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6p21.33

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (30880970..30900156)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (30745627..30764828)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (30848747..30867933)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[MiR-6838-5p overexpression inhibits proliferation of breast cancer MCF-7 cells by downregulating DDR1 expression].
Title: [MiR-6838-5p overexpression inhibits proliferation of breast cancer MCF-7 cells by downregulating DDR1 expression].
DDR1 Drives Malignant Progression of Gastric Cancer by Suppressing HIF-1alpha Ubiquitination and Degradation.
Title: DDR1 Drives Malignant Progression of Gastric Cancer by Suppressing HIF-1α Ubiquitination and Degradation.
Associations of altered leukocyte DDR1 promoter methylation and childhood trauma with bipolar disorder and suicidal behavior in euthymic patients.
Title: Associations of altered leukocyte DDR1 promoter methylation and childhood trauma with bipolar disorder and suicidal behavior in euthymic patients.
Functional Role of DDR1 in Oligodendrocyte Signaling Mechanism in Association with Myelination and Remyelination Process in the Central Nerve System.
Title: Functional Role of DDR1 in Oligodendrocyte Signaling Mechanism in Association with Myelination and Remyelination Process in the Central Nerve System.
Inactivation of kindlin-3 increases human melanoma aggressiveness through the collagen-activated tyrosine kinase receptor DDR1.
Title: Inactivation of kindlin-3 increases human melanoma aggressiveness through the collagen-activated tyrosine kinase receptor DDR1.
Coexpression network analysis of the adult brain sheds light on the pathogenic mechanism of DDR1 in schizophrenia and bipolar disorder.
Title: Coexpression network analysis of the adult brain sheds light on the pathogenic mechanism of DDR1 in schizophrenia and bipolar disorder.
Discoidin Domain Receptor Tyrosine Kinase 1 (DDR1) Is a Novel Therapeutic Target in Liposarcoma: A Tissue Microarray Study.
Title: Discoidin Domain Receptor Tyrosine Kinase 1 (DDR1) Is a Novel Therapeutic Target in Liposarcoma: A Tissue Microarray Study.
DDR1-Induced Paracrine Factors of Hepatocytes Promote HSC Activation and Fibrosis Development.
Title: DDR1-Induced Paracrine Factors of Hepatocytes Promote HSC Activation and Fibrosis Development.
Collagen I-DDR1 signaling promotes hepatocellular carcinoma cell stemness via Hippo signaling repression.
Title: Collagen I-DDR1 signaling promotes hepatocellular carcinoma cell stemness via Hippo signaling repression.
Collagen-induced DDR1 upregulates CXCL5 to promote neutrophil extracellular traps formation and Treg infiltration in breast cancer.
Title: Collagen-induced DDR1 upregulates CXCL5 to promote neutrophil extracellular traps formation and Treg infiltration in breast cancer.

Submit: New GeneRIF Correction See all GeneRIFs (164)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common genetic variation and the control of HIV-1 in humans. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic predictors of medically refractory ulcerative colitis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Seven new loci associated with age-related macular degeneration. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D6S1851 (e-PCR)
- UniSTS:24853

GDB:594103 (e-PCR)
- UniSTS:157986

RH70253 (e-PCR)
- UniSTS:54336

RH11020 (e-PCR)
- UniSTS:73871

WI-18751 (e-PCR)
- UniSTS:32220

D6S2699 (e-PCR)
- UniSTS:256734

RH46779 (e-PCR)
- UniSTS:66537

D6S2203 (e-PCR)
- UniSTS:66538

C4_2_7 (e-PCR)
- UniSTS:239085

RH18132 (e-PCR)
- UniSTS:6395

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables boss receptor activity	IEA Inferred from Electronic Annotation more info
enables brain-derived neurotrophic factor receptor activity	IEA Inferred from Electronic Annotation more info
enables collagen binding	IBA Inferred from Biological aspect of Ancestor more info
enables collagen binding	IDA Inferred from Direct Assay more info	PubMed
enables collagen binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables epidermal growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables hepatocyte growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor activity	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables macrophage colony-stimulating factor receptor activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables placental growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor alpha-receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor beta-receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase collagen receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase collagen receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables stem cell factor receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	TAS Traceable Author Statement more info	PubMed
enables transmembrane-ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Kit signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in axon development	IEA Inferred from Electronic Annotation more info
involved_in brain-derived neurotrophic factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in branching involved in mammary gland duct morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	TAS Traceable Author Statement more info	PubMed
involved_in cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in collagen-activated tyrosine kinase receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in collagen-activated tyrosine kinase receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ear development	IEA Inferred from Electronic Annotation more info
involved_in embryo implantation	IEA Inferred from Electronic Annotation more info
involved_in ephrin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in hepatocyte growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in lactation	IEA Inferred from Electronic Annotation more info
involved_in macrophage colony-stimulating factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in mammary gland alveolus development	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in neuron projection extension	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-tyrosine autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in platelet-derived growth factor receptor-alpha signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor-beta signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
involved_in regulation of extracellular matrix disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in smooth muscle cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor receptor-1 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in wound healing, spreading of cells	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular space	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: epithelial discoidin domain-containing receptor 1

Names: CD167 antigen-like family member A; PTK3A protein tyrosine kinase 3A; cell adhesion kinase; mammary carcinoma kinase 10; neuroepithelial tyrosine kinase; neurotrophic tyrosine kinase, receptor, type 4; protein-tyrosine kinase RTK-6; tyrosine kinase DDR; tyrosine-protein kinase CAK

NP_001189450.1

EC 2.7.10.1

NP_001189451.1

EC 2.7.10.1

NP_001189452.2

EC 2.7.10.1

NP_001284581.1

EC 2.7.10.1

NP_001284582.1

EC 2.7.10.1

NP_001284583.1

EC 2.7.10.1

NP_001374821.1

EC 2.7.10.1

NP_001374822.1

EC 2.7.10.1

NP_001374823.1

EC 2.7.10.1

NP_001374824.1

EC 2.7.10.1

NP_001374825.1

EC 2.7.10.1

NP_001374826.1

EC 2.7.10.1

NP_001374827.1

EC 2.7.10.1

NP_001374828.1

EC 2.7.10.1

NP_001374829.1

EC 2.7.10.1

NP_001374830.1

EC 2.7.10.1

NP_001374831.1

EC 2.7.10.1

NP_001374832.1

EC 2.7.10.1

NP_001374833.1

EC 2.7.10.1

NP_001374834.1

EC 2.7.10.1

NP_001374835.1

EC 2.7.10.1

NP_001374836.1

EC 2.7.10.1

NP_001374837.1

EC 2.7.10.1

NP_001374838.1

EC 2.7.10.1

NP_001374839.1

EC 2.7.10.1

NP_001374840.1

EC 2.7.10.1

NP_001374841.1

EC 2.7.10.1

NP_001374842.1

EC 2.7.10.1

NP_001374843.1

EC 2.7.10.1

NP_001374844.1

EC 2.7.10.1

NP_001374845.1

EC 2.7.10.1

NP_001374846.1

EC 2.7.10.1

NP_001374847.1

EC 2.7.10.1

NP_001397798.1

EC 2.7.10.1

NP_001945.3

EC 2.7.10.1

NP_054699.2

EC 2.7.10.1

NP_054700.2

EC 2.7.10.1

XP_011513186.1

EC 2.7.10.1

XP_011513189.1

EC 2.7.10.1

XP_016866757.1

EC 2.7.10.1

XP_024302308.1

EC 2.7.10.1

XP_024302309.1

EC 2.7.10.1

XP_047275274.1

EC 2.7.10.1

XP_047275275.1

EC 2.7.10.1

XP_047275276.1

EC 2.7.10.1

XP_047275277.1

EC 2.7.10.1

XP_047275278.1

EC 2.7.10.1

XP_047275279.1

EC 2.7.10.1

XP_047275280.1

EC 2.7.10.1

XP_047275281.1

EC 2.7.10.1

XP_047275282.1

EC 2.7.10.1

XP_047275283.1

EC 2.7.10.1

XP_047275284.1

EC 2.7.10.1

XP_047275285.1

EC 2.7.10.1

XP_047275286.1

EC 2.7.10.1

XP_047275287.1

EC 2.7.10.1

XP_047275288.1

EC 2.7.10.1

XP_047275289.1

EC 2.7.10.1

XP_054185845.1

EC 2.7.10.1

XP_054185846.1

EC 2.7.10.1

XP_054185847.1

EC 2.7.10.1

XP_054185848.1

EC 2.7.10.1

XP_054185849.1

EC 2.7.10.1

XP_054185850.1

EC 2.7.10.1

XP_054185851.1

EC 2.7.10.1

XP_054185852.1

EC 2.7.10.1

XP_054185853.1

EC 2.7.10.1

XP_054185854.1

EC 2.7.10.1

XP_054185855.1

EC 2.7.10.1

XP_054185856.1

EC 2.7.10.1

XP_054186331.1

EC 2.7.10.1

XP_054186332.1

EC 2.7.10.1

XP_054186333.1

EC 2.7.10.1

XP_054186334.1

EC 2.7.10.1

XP_054186335.1

EC 2.7.10.1

XP_054186336.1

EC 2.7.10.1

XP_054186337.1

EC 2.7.10.1

XP_054186338.1

EC 2.7.10.1

XP_054186339.1

EC 2.7.10.1

XP_054186340.1

EC 2.7.10.1

XP_054186341.1

EC 2.7.10.1

XP_054186342.1

EC 2.7.10.1

XP_054186343.1

EC 2.7.10.1

XP_054186344.1

EC 2.7.10.1

XP_054186345.1

EC 2.7.10.1

XP_054186346.1

EC 2.7.10.1

XP_054186347.1

EC 2.7.10.1

XP_054186608.1

EC 2.7.10.1

XP_054186609.1

EC 2.7.10.1

XP_054186610.1

EC 2.7.10.1

XP_054186611.1

EC 2.7.10.1

XP_054186612.1

EC 2.7.10.1

XP_054186613.1

EC 2.7.10.1

XP_054186614.1

EC 2.7.10.1

XP_054186615.1

EC 2.7.10.1

XP_054186616.1

EC 2.7.10.1

XP_054186617.1

EC 2.7.10.1

XP_054186618.1

EC 2.7.10.1

XP_054186619.1

EC 2.7.10.1

XP_054186620.1

EC 2.7.10.1

XP_054186621.1

EC 2.7.10.1

XP_054186622.1

EC 2.7.10.1

XP_054186623.1

EC 2.7.10.1

XP_054186624.1

EC 2.7.10.1

XP_054186625.1

EC 2.7.10.1

XP_054186626.1

EC 2.7.10.1

XP_054187105.1

EC 2.7.10.1

XP_054187106.1

EC 2.7.10.1

XP_054187107.1

EC 2.7.10.1

XP_054187108.1

EC 2.7.10.1

XP_054187109.1

EC 2.7.10.1

XP_054187110.1

EC 2.7.10.1

XP_054187111.1

EC 2.7.10.1

XP_054187112.1

EC 2.7.10.1

XP_054187113.1

EC 2.7.10.1

XP_054187114.1

EC 2.7.10.1

XP_054187115.1

EC 2.7.10.1

XP_054187116.1

EC 2.7.10.1

XP_054187117.1

EC 2.7.10.1

XP_054187118.1

EC 2.7.10.1

XP_054187119.1

EC 2.7.10.1

XP_054187120.1

EC 2.7.10.1

XP_054187121.1

EC 2.7.10.1

XP_054187122.1

EC 2.7.10.1

XP_054187123.1

EC 2.7.10.1

XP_054212333.1

EC 2.7.10.1

XP_054212334.1

EC 2.7.10.1

XP_054212335.1

EC 2.7.10.1

XP_054212336.1

EC 2.7.10.1

XP_054212337.1

EC 2.7.10.1

XP_054212338.1

EC 2.7.10.1

XP_054212339.1

EC 2.7.10.1

XP_054212340.1

EC 2.7.10.1

XP_054212341.1

EC 2.7.10.1

XP_054212342.1

EC 2.7.10.1

XP_054212343.1

EC 2.7.10.1

XP_054212344.1

EC 2.7.10.1

XP_054212345.1

EC 2.7.10.1

XP_054212346.1

EC 2.7.10.1

XP_054212347.1

EC 2.7.10.1

XP_054212348.1

EC 2.7.10.1

XP_054212349.1

EC 2.7.10.1

XP_054212350.1

EC 2.7.10.1

XP_054212351.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029066.1 RefSeqGene

Range

5436..21073

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001202521.1 → NP_001189450.1 epithelial discoidin domain-containing receptor 1 isoform 4 precursor

Status: REVIEWED

Source sequence(s)

AF353182, BC008716, L20817

UniProtKB/Swiss-Prot

Q08345

UniProtKB/TrEMBL

Q96T62

Conserved Domains (2) summary

smart00231
Location:30 → 185

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001202522.1 → NP_001189451.1 epithelial discoidin domain-containing receptor 1 isoform 5 precursor

Status: REVIEWED

Source sequence(s)

AF353183, BC008716, L20817

Consensus CDS

CCDS75419.1

UniProtKB/TrEMBL

A0A0A0MSX3, A0A0G2JNZ7

Related

ENSP00000405998.2, ENST00000446312.5

Conserved Domains (2) summary

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cl21453
Location:478 → 761

PKc_like; Protein Kinases, catalytic domain
NM_001202523.3 → NP_001189452.2 epithelial discoidin domain-containing receptor 1 isoform 1 precursor

Status: REVIEWED

Source sequence(s)

AL662870

Consensus CDS

CCDS4690.1

UniProtKB/TrEMBL

A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Conserved Domains (2) summary

cd05096
Location:567 → 870

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001297652.2 → NP_001284581.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_001284581.1

Status: REVIEWED

Source sequence(s)

AK291621, AK294793, BC008716, DA461082

Consensus CDS

CCDS4690.1

UniProtKB/TrEMBL

A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Related

ENSP00000407699.2, ENST00000418800.6

Conserved Domains (2) summary

cd05096
Location:567 → 870

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001297653.2 → NP_001284582.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_001284582.1

Status: REVIEWED

Source sequence(s)

AL662870

Consensus CDS

CCDS4690.1

UniProtKB/TrEMBL

A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Conserved Domains (2) summary

cd05096
Location:567 → 870

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001297654.2 → NP_001284583.1 epithelial discoidin domain-containing receptor 1 isoform 2 precursor

See identical proteins and their annotated locations for NP_001284583.1

Status: REVIEWED

Source sequence(s)

AL662870

Consensus CDS

CCDS34385.1

UniProtKB/Swiss-Prot

B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2

UniProtKB/TrEMBL

A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Related

ENSP00000365752.3, ENST00000376568.8

Conserved Domains (2) summary

cd05096
Location:604 → 907

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001387892.1 → NP_001374821.1 epithelial discoidin domain-containing receptor 1 isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AL662870

Consensus CDS

CCDS47396.1

UniProtKB/TrEMBL

A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Related

ENSP00000427552.1, ENST00000513240.5

Conserved Domains (2) summary

cd05096
Location:604 → 913

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001387893.1 → NP_001374822.1 epithelial discoidin domain-containing receptor 1 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AL662870

Consensus CDS

CCDS34385.1

UniProtKB/Swiss-Prot

B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2

UniProtKB/TrEMBL

A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Conserved Domains (2) summary

cd05096
Location:604 → 907

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001387894.1 → NP_001374823.1 epithelial discoidin domain-containing receptor 1 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AL662870

Consensus CDS

CCDS34385.1

UniProtKB/Swiss-Prot

B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2

UniProtKB/TrEMBL

A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Conserved Domains (2) summary

cd05096
Location:604 → 907

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001387895.1 → NP_001374824.1 epithelial discoidin domain-containing receptor 1 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AL662870

Consensus CDS

CCDS34385.1

UniProtKB/Swiss-Prot

B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2

UniProtKB/TrEMBL

A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Conserved Domains (2) summary

cd05096
Location:604 → 907

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001387896.1 → NP_001374825.1 epithelial discoidin domain-containing receptor 1 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AL662870

Consensus CDS

CCDS34385.1

UniProtKB/Swiss-Prot

B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2

UniProtKB/TrEMBL

A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Conserved Domains (2) summary

cd05096
Location:604 → 907

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001387897.1 → NP_001374826.1 epithelial discoidin domain-containing receptor 1 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AL662870

Consensus CDS

CCDS34385.1

UniProtKB/Swiss-Prot

B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2

UniProtKB/TrEMBL

A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Conserved Domains (2) summary

cd05096
Location:604 → 907

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001387898.1 → NP_001374827.1 epithelial discoidin domain-containing receptor 1 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AL662870

Consensus CDS

CCDS34385.1

UniProtKB/Swiss-Prot

B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2

UniProtKB/TrEMBL

A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Conserved Domains (2) summary

cd05096
Location:604 → 907

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001387899.1 → NP_001374828.1 epithelial discoidin domain-containing receptor 1 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AL662870

Consensus CDS

CCDS34385.1

UniProtKB/Swiss-Prot

B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2

UniProtKB/TrEMBL

A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Conserved Domains (2) summary

cd05096
Location:604 → 907

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001387900.1 → NP_001374829.1 epithelial discoidin domain-containing receptor 1 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AL662870

Consensus CDS

CCDS34385.1

UniProtKB/Swiss-Prot

B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2

UniProtKB/TrEMBL

A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Conserved Domains (2) summary

cd05096
Location:604 → 907

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001387901.1 → NP_001374830.1 epithelial discoidin domain-containing receptor 1 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AL662870

Consensus CDS

CCDS34385.1

UniProtKB/Swiss-Prot

B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2

UniProtKB/TrEMBL

A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Conserved Domains (2) summary

cd05096
Location:604 → 907

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001387902.1 → NP_001374831.1 epithelial discoidin domain-containing receptor 1 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AL662870

Consensus CDS

CCDS34385.1

UniProtKB/Swiss-Prot

B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2

UniProtKB/TrEMBL

A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Conserved Domains (2) summary

cd05096
Location:604 → 907

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001387903.1 → NP_001374832.1 epithelial discoidin domain-containing receptor 1 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AL662870

Consensus CDS

CCDS34385.1

UniProtKB/Swiss-Prot

B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2

UniProtKB/TrEMBL

A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Conserved Domains (2) summary

cd05096
Location:604 → 907

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001387904.1 → NP_001374833.1 epithelial discoidin domain-containing receptor 1 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AL662870

Consensus CDS

CCDS34385.1

UniProtKB/Swiss-Prot

B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2

UniProtKB/TrEMBL

A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Conserved Domains (2) summary

cd05096
Location:604 → 907

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001387905.1 → NP_001374834.1 epithelial discoidin domain-containing receptor 1 isoform 7 precursor

Status: REVIEWED

Source sequence(s)

AL662870

UniProtKB/TrEMBL

A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Conserved Domains (2) summary

cd05096
Location:567 → 876

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001387906.1 → NP_001374835.1 epithelial discoidin domain-containing receptor 1 isoform 7 precursor

Status: REVIEWED

Source sequence(s)

AL662870

UniProtKB/TrEMBL

A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Conserved Domains (2) summary

cd05096
Location:567 → 876

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001387907.1 → NP_001374836.1 epithelial discoidin domain-containing receptor 1 isoform 7 precursor

Status: REVIEWED

Source sequence(s)

AL662870

UniProtKB/TrEMBL

A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Conserved Domains (2) summary

cd05096
Location:567 → 876

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001387908.1 → NP_001374837.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor

Status: REVIEWED

Source sequence(s)

AL662870

Consensus CDS

CCDS4690.1

UniProtKB/TrEMBL

A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Conserved Domains (2) summary

cd05096
Location:567 → 870

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001387909.1 → NP_001374838.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor

Status: REVIEWED

Source sequence(s)

AL662870

Consensus CDS

CCDS4690.1

UniProtKB/TrEMBL

A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Conserved Domains (2) summary

cd05096
Location:567 → 870

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001387910.1 → NP_001374839.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor

Status: REVIEWED

Source sequence(s)

AL662870

Consensus CDS

CCDS4690.1

UniProtKB/TrEMBL

A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Conserved Domains (2) summary

cd05096
Location:567 → 870

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001387911.1 → NP_001374840.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor

Status: REVIEWED

Source sequence(s)

AL662870

Consensus CDS

CCDS4690.1

UniProtKB/TrEMBL

A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Conserved Domains (2) summary

cd05096
Location:567 → 870

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001387912.1 → NP_001374841.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor

Status: REVIEWED

Source sequence(s)

AL662870

Consensus CDS

CCDS4690.1

UniProtKB/TrEMBL

A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Conserved Domains (2) summary

cd05096
Location:567 → 870

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001387913.1 → NP_001374842.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor

Status: REVIEWED

Source sequence(s)

AL662870

Consensus CDS

CCDS4690.1

UniProtKB/TrEMBL

A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Conserved Domains (2) summary

cd05096
Location:567 → 870

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001387914.1 → NP_001374843.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor

Status: REVIEWED

Source sequence(s)

AL662870

Consensus CDS

CCDS4690.1

UniProtKB/TrEMBL

A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Related

ENSP00000365753.3, ENST00000376569.7

Conserved Domains (2) summary

cd05096
Location:567 → 870

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001387915.1 → NP_001374844.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor

Status: REVIEWED

Source sequence(s)

AL662870

Consensus CDS

CCDS4690.1

UniProtKB/TrEMBL

A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Conserved Domains (2) summary

cd05096
Location:567 → 870

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001387916.1 → NP_001374845.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor

Status: REVIEWED

Source sequence(s)

AL662870

Consensus CDS

CCDS4690.1

UniProtKB/TrEMBL

A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Conserved Domains (2) summary

cd05096
Location:567 → 870

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001387917.1 → NP_001374846.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor

Status: REVIEWED

Source sequence(s)

AL662870

Consensus CDS

CCDS4690.1

UniProtKB/TrEMBL

A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Conserved Domains (2) summary

cd05096
Location:567 → 870

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001387918.1 → NP_001374847.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor

Status: REVIEWED

Source sequence(s)

AL662870

Consensus CDS

CCDS4690.1

UniProtKB/TrEMBL

A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Conserved Domains (2) summary

cd05096
Location:567 → 870

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001410869.1 → NP_001397798.1 epithelial discoidin domain-containing receptor 1 isoform 6 precursor

Status: REVIEWED

Source sequence(s)

AL662870

Consensus CDS

CCDS93879.1

Related

ENSP00000422442.1, ENST00000508312.5
NM_001954.5 → NP_001945.3 epithelial discoidin domain-containing receptor 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_001945.3

Status: REVIEWED

Source sequence(s)

BC008716, BC070070

Consensus CDS

CCDS4690.1

UniProtKB/TrEMBL

A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Related

ENSP00000365754.4, ENST00000376570.8

Conserved Domains (2) summary

cd05096
Location:567 → 870

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_013993.3 → NP_054699.2 epithelial discoidin domain-containing receptor 1 isoform 2 precursor

See identical proteins and their annotated locations for NP_054699.2

Status: REVIEWED

Source sequence(s)

AL662870, BC008716, CN362335, L11315

Consensus CDS

CCDS34385.1

UniProtKB/Swiss-Prot

B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2

UniProtKB/TrEMBL

A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Related

ENSP00000405039.1, ENST00000452441.5

Conserved Domains (2) summary

cd05096
Location:604 → 907

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_013994.3 → NP_054700.2 epithelial discoidin domain-containing receptor 1 isoform 3 precursor

See identical proteins and their annotated locations for NP_054700.2

Status: REVIEWED

Source sequence(s)

AL662870

Consensus CDS

CCDS47396.1

UniProtKB/TrEMBL

A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Conserved Domains (2) summary

cd05096
Location:604 → 913

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p14 Primary Assembly

Range

30880970..30900156

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047419324.1 → XP_047275280.1 epithelial discoidin domain-containing receptor 1 isoform X1
XM_011514884.2 → XP_011513186.1 epithelial discoidin domain-containing receptor 1 isoform X5

See identical proteins and their annotated locations for XP_011513186.1

UniProtKB/TrEMBL

A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Conserved Domains (2) summary

cd05096
Location:604 → 913

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
XM_011514887.3 → XP_011513189.1 epithelial discoidin domain-containing receptor 1 isoform X5

See identical proteins and their annotated locations for XP_011513189.1

UniProtKB/TrEMBL

A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Conserved Domains (2) summary

cd05096
Location:604 → 913

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
XM_047419329.1 → XP_047275285.1 epithelial discoidin domain-containing receptor 1 isoform X5
XM_047419318.1 → XP_047275274.1 epithelial discoidin domain-containing receptor 1 isoform X1
XM_024446541.2 → XP_024302309.1 epithelial discoidin domain-containing receptor 1 isoform X5

UniProtKB/TrEMBL

A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Conserved Domains (2) summary

cd05096
Location:604 → 913

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
XM_047419321.1 → XP_047275277.1 epithelial discoidin domain-containing receptor 1 isoform X1
XM_047419322.1 → XP_047275278.1 epithelial discoidin domain-containing receptor 1 isoform X1
XM_047419320.1 → XP_047275276.1 epithelial discoidin domain-containing receptor 1 isoform X1
XM_047419319.1 → XP_047275275.1 epithelial discoidin domain-containing receptor 1 isoform X1
XM_047419326.1 → XP_047275282.1 epithelial discoidin domain-containing receptor 1 isoform X2
XM_047419333.1 → XP_047275289.1 epithelial discoidin domain-containing receptor 1 isoform X3
XM_017011268.3 → XP_016866757.1 epithelial discoidin domain-containing receptor 1 isoform X5

UniProtKB/TrEMBL

A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Conserved Domains (2) summary

cd05096
Location:604 → 913

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
XM_047419323.1 → XP_047275279.1 epithelial discoidin domain-containing receptor 1 isoform X1
XM_047419330.1 → XP_047275286.1 epithelial discoidin domain-containing receptor 1 isoform X5
XM_047419328.1 → XP_047275284.1 epithelial discoidin domain-containing receptor 1 isoform X5
XM_047419325.1 → XP_047275281.1 epithelial discoidin domain-containing receptor 1 isoform X2
XM_047419331.1 → XP_047275287.1 epithelial discoidin domain-containing receptor 1 isoform X4
XM_047419332.1 → XP_047275288.1 epithelial discoidin domain-containing receptor 1 isoform X3
XM_024446540.2 → XP_024302308.1 epithelial discoidin domain-containing receptor 1 isoform X5

UniProtKB/TrEMBL

A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1

Conserved Domains (2) summary

cd05096
Location:604 → 913

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:60 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
XM_047419327.1 → XP_047275283.1 epithelial discoidin domain-containing receptor 1 isoform X5

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

Range

2214565..2218962

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GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

Range

2360739..2379927

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054329873.1 → XP_054185848.1 epithelial discoidin domain-containing receptor 1 isoform X1
XM_054329879.1 → XP_054185854.1 epithelial discoidin domain-containing receptor 1 isoform X5
XM_054329875.1 → XP_054185850.1 epithelial discoidin domain-containing receptor 1 isoform X5
XM_054329881.1 → XP_054185856.1 epithelial discoidin domain-containing receptor 1 isoform X5
XM_054329870.1 → XP_054185845.1 epithelial discoidin domain-containing receptor 1 isoform X1
XM_054329880.1 → XP_054185855.1 epithelial discoidin domain-containing receptor 1 isoform X5
XM_054329872.1 → XP_054185847.1 epithelial discoidin domain-containing receptor 1 isoform X1
XM_054329871.1 → XP_054185846.1 epithelial discoidin domain-containing receptor 1 isoform X1
XM_054329876.1 → XP_054185851.1 epithelial discoidin domain-containing receptor 1 isoform X5
XM_054329874.1 → XP_054185849.1 epithelial discoidin domain-containing receptor 1 isoform X2
XM_054329877.1 → XP_054185852.1 epithelial discoidin domain-containing receptor 1 isoform X5
XM_054329878.1 → XP_054185853.1 epithelial discoidin domain-containing receptor 1 isoform X5

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

Range

2137265..2156466

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054330358.1 → XP_054186333.1 epithelial discoidin domain-containing receptor 1 isoform X6
XM_054330363.1 → XP_054186338.1 epithelial discoidin domain-containing receptor 1 isoform X8
XM_054330365.1 → XP_054186340.1 epithelial discoidin domain-containing receptor 1 isoform X8
XM_054330356.1 → XP_054186331.1 epithelial discoidin domain-containing receptor 1 isoform X6
XM_054330366.1 → XP_054186341.1 epithelial discoidin domain-containing receptor 1 isoform X8
XM_054330357.1 → XP_054186332.1 epithelial discoidin domain-containing receptor 1 isoform X6
XM_054330360.1 → XP_054186335.1 epithelial discoidin domain-containing receptor 1 isoform X8
XM_054330369.1 → XP_054186344.1 epithelial discoidin domain-containing receptor 1 isoform X9
XM_054330372.1 → XP_054186347.1 epithelial discoidin domain-containing receptor 1 isoform X12
XM_054330367.1 → XP_054186342.1 epithelial discoidin domain-containing receptor 1 isoform X8
XM_054330368.1 → XP_054186343.1 epithelial discoidin domain-containing receptor 1 isoform X8
XM_054330364.1 → XP_054186339.1 epithelial discoidin domain-containing receptor 1 isoform X8
XM_054330359.1 → XP_054186334.1 epithelial discoidin domain-containing receptor 1 isoform X7
XM_054330370.1 → XP_054186345.1 epithelial discoidin domain-containing receptor 1 isoform X10
XM_054330371.1 → XP_054186346.1 epithelial discoidin domain-containing receptor 1 isoform X11
XM_054330361.1 → XP_054186336.1 epithelial discoidin domain-containing receptor 1 isoform X8
XM_054330362.1 → XP_054186337.1 epithelial discoidin domain-containing receptor 1 isoform X8

Reference GRCh38.p14 ALT_REF_LOCI_4

Genomic

NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

Range

2191212..2210394

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054330638.1 → XP_054186613.1 epithelial discoidin domain-containing receptor 1 isoform X1
XM_054330645.1 → XP_054186620.1 epithelial discoidin domain-containing receptor 1 isoform X5
XM_054330641.1 → XP_054186616.1 epithelial discoidin domain-containing receptor 1 isoform X5
XM_054330648.1 → XP_054186623.1 epithelial discoidin domain-containing receptor 1 isoform X5
XM_054330633.1 → XP_054186608.1 epithelial discoidin domain-containing receptor 1 isoform X1
XM_054330647.1 → XP_054186622.1 epithelial discoidin domain-containing receptor 1 isoform X5
XM_054330636.1 → XP_054186611.1 epithelial discoidin domain-containing receptor 1 isoform X1
XM_054330637.1 → XP_054186612.1 epithelial discoidin domain-containing receptor 1 isoform X1
XM_054330635.1 → XP_054186610.1 epithelial discoidin domain-containing receptor 1 isoform X1
XM_054330634.1 → XP_054186609.1 epithelial discoidin domain-containing receptor 1 isoform X1
XM_054330640.1 → XP_054186615.1 epithelial discoidin domain-containing receptor 1 isoform X2
XM_054330651.1 → XP_054186626.1 epithelial discoidin domain-containing receptor 1 isoform X3
XM_054330642.1 → XP_054186617.1 epithelial discoidin domain-containing receptor 1 isoform X5
XM_054330646.1 → XP_054186621.1 epithelial discoidin domain-containing receptor 1 isoform X5
XM_054330639.1 → XP_054186614.1 epithelial discoidin domain-containing receptor 1 isoform X2
XM_054330649.1 → XP_054186624.1 epithelial discoidin domain-containing receptor 1 isoform X4
XM_054330650.1 → XP_054186625.1 epithelial discoidin domain-containing receptor 1 isoform X3
XM_054330643.1 → XP_054186618.1 epithelial discoidin domain-containing receptor 1 isoform X5
XM_054330644.1 → XP_054186619.1 epithelial discoidin domain-containing receptor 1 isoform X5

Reference GRCh38.p14 ALT_REF_LOCI_5

Genomic

NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

Range

2225119..2249066

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GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

Range

2136138..2155326

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054331135.1 → XP_054187110.1 epithelial discoidin domain-containing receptor 1 isoform X1
XM_054331142.1 → XP_054187117.1 epithelial discoidin domain-containing receptor 1 isoform X5
XM_054331138.1 → XP_054187113.1 epithelial discoidin domain-containing receptor 1 isoform X5
XM_054331145.1 → XP_054187120.1 epithelial discoidin domain-containing receptor 1 isoform X5
XM_054331130.1 → XP_054187105.1 epithelial discoidin domain-containing receptor 1 isoform X1
XM_054331144.1 → XP_054187119.1 epithelial discoidin domain-containing receptor 1 isoform X5
XM_054331133.1 → XP_054187108.1 epithelial discoidin domain-containing receptor 1 isoform X1
XM_054331134.1 → XP_054187109.1 epithelial discoidin domain-containing receptor 1 isoform X1
XM_054331132.1 → XP_054187107.1 epithelial discoidin domain-containing receptor 1 isoform X1
XM_054331131.1 → XP_054187106.1 epithelial discoidin domain-containing receptor 1 isoform X1
XM_054331137.1 → XP_054187112.1 epithelial discoidin domain-containing receptor 1 isoform X2
XM_054331148.1 → XP_054187123.1 epithelial discoidin domain-containing receptor 1 isoform X3
XM_054331139.1 → XP_054187114.1 epithelial discoidin domain-containing receptor 1 isoform X5
XM_054331143.1 → XP_054187118.1 epithelial discoidin domain-containing receptor 1 isoform X5
XM_054331136.1 → XP_054187111.1 epithelial discoidin domain-containing receptor 1 isoform X2
XM_054331146.1 → XP_054187121.1 epithelial discoidin domain-containing receptor 1 isoform X4
XM_054331147.1 → XP_054187122.1 epithelial discoidin domain-containing receptor 1 isoform X3
XM_054331140.1 → XP_054187115.1 epithelial discoidin domain-containing receptor 1 isoform X5
XM_054331141.1 → XP_054187116.1 epithelial discoidin domain-containing receptor 1 isoform X5

Alternate T2T-CHM13v2.0

Genomic

NC_060930.1 Alternate T2T-CHM13v2.0

Range

30745627..30764828

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054356365.1 → XP_054212340.1 epithelial discoidin domain-containing receptor 1 isoform X1
XM_054356371.1 → XP_054212346.1 epithelial discoidin domain-containing receptor 1 isoform X5
XM_054356375.1 → XP_054212350.1 epithelial discoidin domain-containing receptor 1 isoform X5
XM_054356374.1 → XP_054212349.1 epithelial discoidin domain-containing receptor 1 isoform X5
XM_054356366.1 → XP_054212341.1 epithelial discoidin domain-containing receptor 1 isoform X2
XM_054356369.1 → XP_054212344.1 epithelial discoidin domain-containing receptor 1 isoform X5
XM_054356370.1 → XP_054212345.1 epithelial discoidin domain-containing receptor 1 isoform X5
XM_054356358.1 → XP_054212333.1 epithelial discoidin domain-containing receptor 1 isoform X1
XM_054356373.1 → XP_054212348.1 epithelial discoidin domain-containing receptor 1 isoform X5
XM_054356359.1 → XP_054212334.1 epithelial discoidin domain-containing receptor 1 isoform X1
XM_054356362.1 → XP_054212337.1 epithelial discoidin domain-containing receptor 1 isoform X1
XM_054356364.1 → XP_054212339.1 epithelial discoidin domain-containing receptor 1 isoform X1
XM_054356363.1 → XP_054212338.1 epithelial discoidin domain-containing receptor 1 isoform X1
XM_054356361.1 → XP_054212336.1 epithelial discoidin domain-containing receptor 1 isoform X1
XM_054356367.1 → XP_054212342.1 epithelial discoidin domain-containing receptor 1 isoform X2
XM_054356376.1 → XP_054212351.1 epithelial discoidin domain-containing receptor 1 isoform X3
XM_054356372.1 → XP_054212347.1 epithelial discoidin domain-containing receptor 1 isoform X5
XM_054356368.1 → XP_054212343.1 epithelial discoidin domain-containing receptor 1 isoform X5
XM_054356360.1 → XP_054212335.1 epithelial discoidin domain-containing receptor 1 isoform X1