STK3 serine/threonine kinase 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: STK3provided by HGNC
Official Full Name: serine/threonine kinase 3provided by HGNC
Primary source: HGNC:HGNC:11406
See related: Ensembl:ENSG00000104375 MIM:605030; AllianceGenome:HGNC:11406
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: KRS1; MST2
Summary: This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Expression: Ubiquitous expression in endometrium (RPKM 3.0), placenta (RPKM 2.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8q22.2

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (98343975..98942610, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (99469462..100069002, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (99466861..99954838, complement)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Association Study between SNPs in MST1 and MST2 and H. pylori Infection as well as Noncardia Gastric Carcinogenesis.
Title: Association Study between SNPs in MST1 and MST2 and H. pylori Infection as well as Noncardia Gastric Carcinogenesis.
Identification of a novel alternative splicing isoform of the Hippo kinase STK3/MST2 with impaired kinase and cell growth suppressing activities.
Title: Identification of a novel alternative splicing isoform of the Hippo kinase STK3/MST2 with impaired kinase and cell growth suppressing activities.
STK3 kinase activation inhibits tumor proliferation through FOXO1-TP53INP1/P21 pathway in esophageal squamous cell carcinoma.
Title: STK3 kinase activation inhibits tumor proliferation through FOXO1-TP53INP1/P21 pathway in esophageal squamous cell carcinoma.
The Mst1/2-BNIP3 axis is required for mitophagy induction and neuronal viability under mitochondrial stress.
Title: The Mst1/2-BNIP3 axis is required for mitophagy induction and neuronal viability under mitochondrial stress.
Smurf1 polyubiquitinates on K285/K282 of the kinases Mst1/2 to attenuate their tumor-suppressor functions.
Title: Smurf1 polyubiquitinates on K285/K282 of the kinases Mst1/2 to attenuate their tumor-suppressor functions.
MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression.
Title: MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression.
The TRIM69-MST2 signaling axis regulates centrosome dynamics and chromosome segregation.
Title: The TRIM69-MST2 signaling axis regulates centrosome dynamics and chromosome segregation.
TRIM21 is a druggable target for the treatment of metastatic colorectal cancer through ubiquitination and activation of MST2.
Title: TRIM21 is a druggable target for the treatment of metastatic colorectal cancer through ubiquitination and activation of MST2.
Mammalian STE20-like kinase-1/2 are activated in human platelets stimulated by collagen or thrombin and play a vital role in collagen-activated platelets.
Title: Mammalian STE20-like kinase-1/2 are activated in human platelets stimulated by collagen or thrombin and play a vital role in collagen-activated platelets.
Extracellular matrix stiffness regulates degradation of MST2 via SCF <sup>betaTrCP</sup>.
Title: Extracellular matrix stiffness regulates degradation of MST2 via SCF (βTrCP).

Submit: New GeneRIF Correction See all GeneRIFs (69)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-32998 (e-PCR)
- UniSTS:63250

RH103761 (e-PCR)
- UniSTS:98086

D8S1924 (e-PCR)
- UniSTS:74810

RH64860 (e-PCR)
- UniSTS:89236

G49552 (e-PCR)
- UniSTS:109222

RH38901 (e-PCR)
- UniSTS:85168

WI-20184 (e-PCR)
- UniSTS:54716

D8S2107 (e-PCR)
- UniSTS:3799

WI-18654 (e-PCR)
- UniSTS:57571

G17283 (e-PCR)
- UniSTS:33772

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activator activity	TAS Traceable Author Statement more info	PubMed
enables protein serine/threonine kinase activity	EXP Inferred from Experiment more info	PubMed
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
enables transcription regulator activator activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation involved in embryonic placenta development	IEA Inferred from Electronic Annotation more info
involved_in central nervous system development	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in endocardium development	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in extrinsic apoptotic signaling pathway via death domain receptors	IEA Inferred from Electronic Annotation more info
involved_in hepatocyte apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in hippo signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in hippo signaling	TAS Traceable Author Statement more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of organ growth	IEA Inferred from Electronic Annotation more info
involved_in neural tube formation	IEA Inferred from Electronic Annotation more info
involved_in organ growth	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fat cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of hippo signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in primitive hemopoiesis	IEA Inferred from Electronic Annotation more info
involved_in protein import into nucleus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization to centrosome	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein tetramerization	IEA Inferred from Electronic Annotation more info
involved_in regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell differentiation involved in embryonic placenta development	IEA Inferred from Electronic Annotation more info
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in centrosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein kinase 3

Names: KB-1458E12.1; MST-2; STE20-like kinase MST2; epididymis secretory sperm binding protein; hippo homolog; mammalian STE20-like protein kinase 2; serine/threonine kinase 3 (STE20 homolog, yeast); serine/threonine kinase 3 (Ste20, yeast homolog); serine/threonine-protein kinase Krs-1

NP_001243241.1

EC 2.7.11.1

NP_001243242.1

EC 2.7.11.1

NP_006272.2

EC 2.7.11.1

XP_011515550.2

EC 2.7.11.1

XP_011515553.1

EC 2.7.11.1

XP_011515554.2

EC 2.7.11.1

XP_011515559.2

EC 2.7.11.1

XP_016869245.1

EC 2.7.11.1

XP_016869246.1

EC 2.7.11.1

XP_016869247.1

EC 2.7.11.1

XP_016869250.1

EC 2.7.11.1

XP_047278088.1

EC 2.7.11.1

XP_047278089.1

EC 2.7.11.1

XP_047278090.1

EC 2.7.11.1

XP_047278091.1

EC 2.7.11.1

XP_047278092.1

EC 2.7.11.1

XP_047278093.1

EC 2.7.11.1

XP_054217046.1

EC 2.7.11.1

XP_054217047.1

EC 2.7.11.1

XP_054217048.1

EC 2.7.11.1

XP_054217049.1

EC 2.7.11.1

XP_054217050.1

EC 2.7.11.1

XP_054217051.1

EC 2.7.11.1

XP_054217052.1

EC 2.7.11.1

XP_054217053.1

EC 2.7.11.1

XP_054217054.1

EC 2.7.11.1

XP_054217055.1

EC 2.7.11.1

XP_054217056.1

EC 2.7.11.1

XP_054217057.1

EC 2.7.11.1

XP_054217058.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001256312.2 → NP_001243241.1 serine/threonine-protein kinase 3 isoform 2

See identical proteins and their annotated locations for NP_001243241.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding region, and uses an alternate start codon compared to variant 1. The resulting protein (isoform 2) has a longer N-terminus compared to isoform 1.

Source sequence(s)

AC016877, AK131363, AP003355

Consensus CDS

CCDS59108.1

UniProtKB/Swiss-Prot

Q13188

Related

ENSP00000429744.1, ENST00000523601.5

Conserved Domains (3) summary

cd06612
Location:51 → 306

STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2

smart00220
Location:55 → 306

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam11629
Location:465 → 512

Mst1_SARAH; C terminal SARAH domain of Mst1
NM_001256313.2 → NP_001243242.1 serine/threonine-protein kinase 3 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.

Source sequence(s)

AA370619, AK307787, AP002087, AP003355, AP003551

Consensus CDS

CCDS75774.1

UniProtKB/TrEMBL

A0A087WZ06

Related

ENSP00000482260.1, ENST00000617590.1

Conserved Domains (2) summary

pfam11629
Location:326 → 373

Mst1_SARAH; C terminal SARAH domain of Mst1

cl21453
Location:23 → 167

PKc_like; Protein Kinases, catalytic domain
NM_006281.4 → NP_006272.2 serine/threonine-protein kinase 3 isoform 1

See identical proteins and their annotated locations for NP_006272.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AP003551, BC010640, U26424

Consensus CDS

CCDS47900.1

UniProtKB/Swiss-Prot

A8K722, B3KYA7, Q13188, Q15445, Q15801, Q96FM6

UniProtKB/TrEMBL

A0A384MR07

Related

ENSP00000390500.2, ENST00000419617.7

Conserved Domains (2) summary

cd06612
Location:23 → 278

STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2

pfam11629
Location:437 → 484

Mst1_SARAH; C terminal SARAH domain of Mst1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000008.11 Reference GRCh38.p14 Primary Assembly

Range

98343975..98942610 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047422133.1 → XP_047278089.1 serine/threonine-protein kinase 3 isoform X6
XM_017013756.2 → XP_016869245.1 serine/threonine-protein kinase 3 isoform X1
XM_011517251.3 → XP_011515553.1 serine/threonine-protein kinase 3 isoform X4

Conserved Domains (2) summary

cd06612
Location:23 → 278

STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2

smart00220
Location:27 → 278

S_TKc; Serine/Threonine protein kinases, catalytic domain
XM_047422132.1 → XP_047278088.1 serine/threonine-protein kinase 3 isoform X5
XM_011517252.4 → XP_011515554.2 serine/threonine-protein kinase 3 isoform X7
XM_011517248.3 → XP_011515550.2 serine/threonine-protein kinase 3 isoform X2
XM_047422135.1 → XP_047278091.1 serine/threonine-protein kinase 3 isoform X11
XM_017013761.3 → XP_016869250.1 serine/threonine-protein kinase 3 isoform X10
XM_017013758.2 → XP_016869247.1 serine/threonine-protein kinase 3 isoform X8
XM_047422134.1 → XP_047278090.1 serine/threonine-protein kinase 3 isoform X9
XM_017013757.2 → XP_016869246.1 serine/threonine-protein kinase 3 isoform X3
XM_011517257.3 → XP_011515559.2 serine/threonine-protein kinase 3 isoform X13
XM_047422137.1 → XP_047278093.1 serine/threonine-protein kinase 3 isoform X14
XM_047422136.1 → XP_047278092.1 serine/threonine-protein kinase 3 isoform X12