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    UBL7 ubiquitin like 7 [ Homo sapiens (human) ]

    Gene ID: 84993, updated on 10-Dec-2024

    Summary

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    Official Symbol
    UBL7provided by HGNC
    Official Full Name
    ubiquitin like 7provided by HGNC
    Primary source
    HGNC:HGNC:28221
    See related
    Ensembl:ENSG00000138629 MIM:609748; AllianceGenome:HGNC:28221
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TCBA1; BMSC-UbP
    Summary
    Enables molecular adaptor activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Is active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 17.2), brain (RPKM 14.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See UBL7 in Genome Data Viewer
    Location:
    15q24.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (74445977..74461188, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (72313701..72328914, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (74738318..74753529, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9750 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9751 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9752 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74675326-74675826 Neighboring gene long intergenic non-protein coding RNA 2255 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9753 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:74676645-74677844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74678372-74678912 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74678913-74679452 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:74679453-74679994 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:74679995-74680534 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:74680535-74681075 Neighboring gene CRISPRi-validated cis-regulatory element chr15.2230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9757 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9758 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:74688843-74690042 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9762 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74692014-74692514 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74693783-74694283 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9764 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74695428-74696393 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9768 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9769 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9770 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9771 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74701581-74702081 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74703990-74704490 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74704491-74704991 Neighboring gene semaphorin 7A (JohnMiltonHagen blood group) Neighboring gene microRNA 6881 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:74713934-74714565 Neighboring gene Sharpr-MPRA regulatory region 521 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:74715829-74716459 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9773 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9774 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9775 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6649 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6650 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6651 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:74734123-74734632 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:74734999-74735183 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:74735145-74735654 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:74741828-74742328 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9776 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74751547-74752066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74752067-74752586 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:74752742-74753588 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74754520-74755020 Neighboring gene UBL7 divergent transcript Neighboring gene small nucleolar RNA SNORD77

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Solution structure of the ubiquitin-associated domain of human BMSC-UbP and its complex with ubiquitin. Chang YG, et al. Protein Sci, 2006 Jun. PMID 16731964, Free PMC Article
    2. Cloning and identification of a novel ubiquitin-like protein, BMSC-UbP, from human bone marrow stromal cells. Liu S, et al. Immunol Lett, 2003 Apr 3. PMID 12644319
    3. UBL7 enhances antiviral innate immunity by promoting Lys27-linked polyubiquitination of MAVS. Jiang W, et al. Cell Rep, 2023 Mar 28. PMID 36943869
    4. Selectivity of the CUBAN domain in the recognition of ubiquitin and NEDD8. Castagnoli L, et al. FEBS J, 2019 Feb. PMID 30659753
    5. Identification of polyubiquitin binding proteins involved in NF-kappaB signaling using protein arrays. Fenner BJ, et al. Biochim Biophys Acta, 2009 Jul. PMID 19285159

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the solution NMR structure of the ubiquitin-associated domain of the human BMSC-UbP protein and its complex with ubiquitin
      Title: Solution structure of the ubiquitin-associated domain of human BMSC-UbP and its complex with ubiquitin.
    2. BMSC-UbP might play roles in regulation of BMSC function or cell differentiation through an evocator- and cell-specific pattern.
      Title: Cloning and identification of a novel ubiquitin-like protein, BMSC-UbP, from human bone marrow stromal cells.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC14421

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-like protein 7
    Names
    ubiquitin-like 7 (bone marrow stromal cell-derived)
    ubiquitin-like protein SB132

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286739.2 → NP_001273668.1  ubiquitin-like protein 7 isoform a

      See identical proteins and their annotated locations for NP_001273668.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (a).
      Source sequence(s)
      BC030055, BG704085, HY135530
      Consensus CDS
      CCDS10263.1
      UniProtKB/Swiss-Prot
      D3DW57, Q96I03, Q96S82
      Related
      ENSP00000457708.1, ENST00000565335.5
      Conserved Domains (2) summary
      cd01815
      Location:18 → 92
      BMSC_UbP_N; Ubiquitin-like domain of BMSC-UbP
      cd14326
      Location:346 → 375
      UBA_UBL7; UBA domain found in ubiquitin-like protein 7 (UBL7) and similar proteins

    2. NM_001286740.1 → NP_001273669.1  ubiquitin-like protein 7 isoform a

      See identical proteins and their annotated locations for NP_001273669.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (a).
      Source sequence(s)
      BC007913, HY135530
      Consensus CDS
      CCDS10263.1
      UniProtKB/Swiss-Prot
      D3DW57, Q96I03, Q96S82
      Conserved Domains (2) summary
      cd01815
      Location:18 → 92
      BMSC_UbP_N; Ubiquitin-like domain of BMSC-UbP
      cd14326
      Location:346 → 375
      UBA_UBL7; UBA domain found in ubiquitin-like protein 7 (UBL7) and similar proteins

    3. NM_001286741.2 → NP_001273670.1  ubiquitin-like protein 7 isoform b

      See identical proteins and their annotated locations for NP_001273670.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a longer N-terminus, compared to isoform a. Both variants 5 and 6 encode the same isoform.
      Source sequence(s)
      BC007913, BP192909
      Conserved Domains (3) summary
      cd01815
      Location:58 → 132
      BMSC_UbP_N; Ubiquitin-like domain of BMSC-UbP
      smart00213
      Location:79 → 130
      UBQ; Ubiquitin homologues
      cd14326
      Location:386 → 415
      UBA_UBL7; UBA domain found in ubiquitin-like protein 7 (UBL7) and similar proteins

    4. NM_001286742.2 → NP_001273671.1  ubiquitin-like protein 7 isoform b

      See identical proteins and their annotated locations for NP_001273671.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a longer N-terminus, compared to isoform a. Both variants 5 and 6 encode the same isoform.
      Source sequence(s)
      BC030055, BC033919, BP192909
      Conserved Domains (3) summary
      cd01815
      Location:58 → 132
      BMSC_UbP_N; Ubiquitin-like domain of BMSC-UbP
      smart00213
      Location:79 → 130
      UBQ; Ubiquitin homologues
      cd14326
      Location:386 → 415
      UBA_UBL7; UBA domain found in ubiquitin-like protein 7 (UBL7) and similar proteins

    5. NM_032907.5 → NP_116296.1  ubiquitin-like protein 7 isoform a

      See identical proteins and their annotated locations for NP_116296.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the shorter isoform (a). Variants 1-4 encode the same isoform.
      Source sequence(s)
      BC007913, BP192909
      Consensus CDS
      CCDS10263.1
      UniProtKB/Swiss-Prot
      D3DW57, Q96I03, Q96S82
      Related
      ENSP00000378518.2, ENST00000395081.7
      Conserved Domains (2) summary
      cd01815
      Location:18 → 92
      BMSC_UbP_N; Ubiquitin-like domain of BMSC-UbP
      cd14326
      Location:346 → 375
      UBA_UBL7; UBA domain found in ubiquitin-like protein 7 (UBL7) and similar proteins

    6. NM_201265.2 → NP_957717.1  ubiquitin-like protein 7 isoform a

      See identical proteins and their annotated locations for NP_957717.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (a).
      Source sequence(s)
      BC007913, BI552240
      Consensus CDS
      CCDS10263.1
      UniProtKB/Swiss-Prot
      D3DW57, Q96I03, Q96S82
      Related
      ENSP00000354883.4, ENST00000361351.8
      Conserved Domains (2) summary
      cd01815
      Location:18 → 92
      BMSC_UbP_N; Ubiquitin-like domain of BMSC-UbP
      cd14326
      Location:346 → 375
      UBA_UBL7; UBA domain found in ubiquitin-like protein 7 (UBL7) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      74445977..74461188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011522124.3 → XP_011520426.1  ubiquitin-like protein 7 isoform X1

      See identical proteins and their annotated locations for XP_011520426.1

      Conserved Domains (3) summary
      cd01815
      Location:58 → 132
      BMSC_UbP_N; Ubiquitin-like domain of BMSC-UbP
      smart00213
      Location:79 → 130
      UBQ; Ubiquitin homologues
      cd14326
      Location:386 → 415
      UBA_UBL7; UBA domain found in ubiquitin-like protein 7 (UBL7) and similar proteins

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_021160016.1 Reference GRCh38.p14 PATCHES

      Range
      275246..290457 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332567.1 → XP_054188542.1  ubiquitin-like protein 7 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      72313701..72328914 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379032.1 → XP_054235007.1  ubiquitin-like protein 7 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96S82.2 GenPept UniProtKB/Swiss-Prot:Q96S82

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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