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    LRRIQ1 leucine rich repeats and IQ motif containing 1 [ Homo sapiens (human) ]

    Gene ID: 84125, updated on 9-Dec-2024

    Summary

    Official Symbol
    LRRIQ1provided by HGNC
    Official Full Name
    leucine rich repeats and IQ motif containing 1provided by HGNC
    Primary source
    HGNC:HGNC:25708
    See related
    Ensembl:ENSG00000133640 MIM:620922; AllianceGenome:HGNC:25708
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be involved in regulation of signal transduction. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis (RPKM 3.9), lung (RPKM 0.9) and 4 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See LRRIQ1 in Genome Data Viewer
    Location:
    12q21.31
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (85036351..85272805)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (85015741..85253151)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (85430129..85638883)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:85306245-85306792 Neighboring gene uncharacterized LOC102724680 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:85306793-85307339 Neighboring gene NANOG hESC enhancer GRCh37_chr12:85397904-85398436 Neighboring gene Sharpr-MPRA regulatory region 14945 Neighboring gene tetraspanin 19 Neighboring gene Sharpr-MPRA regulatory region 79 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr12:85711317-85711919 and GRCh37_chr12:85711920-85712521 Neighboring gene long intergenic non-protein coding RNA 2820 Neighboring gene ALX homeobox 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6693 Neighboring gene uncharacterized LOC107984537 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6694

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of leucine-rich repeats and IQ motif containing 1 (LRRIQ1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ12303

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    leucine-rich repeat- and IQ domain-containing protein 1; leucine-rich repeat and IQ domain-containing protein 1
    Names
    testicular tissue protein Li 111

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079910.2NP_001073379.1  leucine-rich repeat- and IQ domain-containing protein 1

      See identical proteins and their annotated locations for NP_001073379.1

      Status: VALIDATED

      Source sequence(s)
      AB058704, AC079631, AU122206, BU608190, BU677204, CA502842, DB447399, DN831755
      Consensus CDS
      CCDS41816.1
      UniProtKB/Swiss-Prot
      Q567P4, Q96JM4, Q9BS17, Q9HA36
      UniProtKB/TrEMBL
      A0A140VJN5
      Related
      ENSP00000376910.2, ENST00000393217.7
      Conserved Domains (5) summary
      smart00015
      Location:13381354
      IQ; Calmodulin-binding motif
      cd00116
      Location:9631095
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:820841
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:818856
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:10371091
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      85036351..85272805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011538819.4XP_011537121.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X3

      Conserved Domains (5) summary
      smart00015
      Location:13381354
      IQ; Calmodulin-binding motif
      cd00116
      Location:9631095
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:820841
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:818856
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:10371091
      LRR_8; Leucine rich repeat
    2. XM_024449222.2XP_024304990.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X7

      Conserved Domains (5) summary
      smart00015
      Location:13381354
      IQ; Calmodulin-binding motif
      sd00033
      Location:820841
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:10371091
      LRR_8; Leucine rich repeat
      cl26018
      Location:9711108
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26511
      Location:162644
      Neuromodulin_N; Gap junction protein N-terminal region
    3. XM_011538817.3XP_011537119.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X1

      Conserved Domains (6) summary
      smart00015
      Location:13381354
      IQ; Calmodulin-binding motif
      cd00116
      Location:9631095
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:820841
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:818856
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:10371091
      LRR_8; Leucine rich repeat
      pfam14988
      Location:164343
      DUF4515; Domain of unknown function (DUF4515)
    4. XM_024449221.2XP_024304989.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X6

      Conserved Domains (5) summary
      smart00015
      Location:13381354
      IQ; Calmodulin-binding motif
      sd00033
      Location:820841
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:10371091
      LRR_8; Leucine rich repeat
      cl26018
      Location:9711108
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26511
      Location:162644
      Neuromodulin_N; Gap junction protein N-terminal region
    5. XM_047429655.1XP_047285611.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X12

    6. XM_011538818.3XP_011537120.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X2

      Conserved Domains (5) summary
      smart00015
      Location:13381354
      IQ; Calmodulin-binding motif
      cd00116
      Location:9631095
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:820841
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:818856
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:10371091
      LRR_8; Leucine rich repeat
    7. XM_024449220.2XP_024304988.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X5

      Conserved Domains (5) summary
      smart00015
      Location:13381354
      IQ; Calmodulin-binding motif
      sd00033
      Location:820841
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:10371091
      LRR_8; Leucine rich repeat
      cl26018
      Location:9711108
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26511
      Location:162644
      Neuromodulin_N; Gap junction protein N-terminal region
    8. XM_047429651.1XP_047285607.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X4

    9. XM_047429652.1XP_047285608.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X4

    10. XM_047429656.1XP_047285612.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X13

    11. XM_047429657.1XP_047285613.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X14

    12. XM_047429653.1XP_047285609.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X8

    13. XM_024449223.2XP_024304991.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X9

      Conserved Domains (5) summary
      smart00015
      Location:13381354
      IQ; Calmodulin-binding motif
      sd00033
      Location:820841
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:10371091
      LRR_8; Leucine rich repeat
      cl26018
      Location:9711108
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26511
      Location:162644
      Neuromodulin_N; Gap junction protein N-terminal region
    14. XM_047429654.1XP_047285610.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X11

    15. XM_011538823.3XP_011537125.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X10

      Conserved Domains (5) summary
      smart00015
      Location:13381354
      IQ; Calmodulin-binding motif
      cd00116
      Location:9631095
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:820841
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:818856
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:10371091
      LRR_8; Leucine rich repeat
    16. XM_011538824.3XP_011537126.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X16

      Related
      ENST00000525971.6
      Conserved Domains (5) summary
      smart00015
      Location:13381354
      IQ; Calmodulin-binding motif
      cd00116
      Location:9631095
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:820841
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:818856
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:10371091
      LRR_8; Leucine rich repeat
    17. XM_011538825.3XP_011537127.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X15

      Conserved Domains (3) summary
      sd00033
      Location:820841
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:818856
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:10151070
      LRR_8; Leucine rich repeat

    RNA

    1. XR_944764.3 RNA Sequence

    2. XR_944765.3 RNA Sequence

    3. XR_944766.3 RNA Sequence

    4. XR_001748890.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      85015741..85253151
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373435.1XP_054229410.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X3

    2. XM_054373440.1XP_054229415.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X7

    3. XM_054373433.1XP_054229408.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X1

    4. XM_054373439.1XP_054229414.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X6

    5. XM_054373445.1XP_054229420.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X12

    6. XM_054373434.1XP_054229409.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X2

    7. XM_054373438.1XP_054229413.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X5

    8. XM_054373436.1XP_054229411.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X4

    9. XM_054373437.1XP_054229412.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X4

    10. XM_054373446.1XP_054229421.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X13

    11. XM_054373447.1XP_054229422.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X14

    12. XM_054373441.1XP_054229416.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X8

    13. XM_054373442.1XP_054229417.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X9

    14. XM_054373444.1XP_054229419.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X11

    15. XM_054373443.1XP_054229418.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X10

    16. XM_054373448.1XP_054229423.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X15

    RNA

    1. XR_008488693.1 RNA Sequence

    2. XR_008488694.1 RNA Sequence

    3. XR_008488695.1 RNA Sequence

    4. XR_008488696.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_032165.3: Suppressed sequence

      Description
      NM_032165.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.