GRIK3 glutamate ionotropic receptor kainate type subunit 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GRIK3provided by HGNC
Official Full Name: glutamate ionotropic receptor kainate type subunit 3provided by HGNC
Primary source: HGNC:HGNC:4581
See related: Ensembl:ENSG00000163873 MIM:138243; AllianceGenome:HGNC:4581
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: EAA5; GLR7; GLUR7; GluK3; GluR7a
Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq, Jul 2008]
Expression: Biased expression in brain (RPKM 3.5), adrenal (RPKM 0.5) and 6 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p34.3

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (36795527..37034515, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (36659019..36898269, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (37261128..37500116, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CircASXL1 knockdown represses the progression of colorectal cancer by downregulating GRIK3 expression by sponging miR-1205.
Title: CircASXL1 knockdown represses the progression of colorectal cancer by downregulating GRIK3 expression by sponging miR-1205.
Mechanically, GRIK3 influenced a range of signaling pathways and key signal transducers, including two epithelial-mesenchymal transition regulators, SPDEF and CDH1. Moreover, overexpression of GRIK3 increased the expression of mesenchymal markers and decreased the expression of epithelial markers, resulting in the translocation of beta-catenin into the nucleus and the increased beta-catenin transcriptional activity.
Title: Glutamate Ionotropic Receptor Kainate Type Subunit 3 (GRIK3) promotes epithelial-mesenchymal transition in breast cancer cells by regulating SPDEF/CDH1 signaling.
additional experiment showed that the lymph node metastasis tissues had higher GRIK3 expression than their matched primary gastric cancer (GC) tissues. These findings suggested that elevated GRIK3 expression could serve as an independent prognostic biomarker and a novel potential treatment target for patients with GC.
Title: GRIK3: A novel oncogenic protein related to tumor TNM stage, lymph node metastasis, and poor prognosis of GC.
GRIK3 expression is significantly downregulated in human masticatory mucosa during wound healing
Title: Human gingiva transcriptome during wound healing.
1p34.3 deletion involving GRIK3: Further clinical implication of GRIK family glutamate receptors in the pathogenesis of developmental delay.
Title: 1p34.3 deletion involving GRIK3: Further clinical implication of GRIK family glutamate receptors in the pathogenesis of developmental delay.
Analyses revealed that polymorphism Ser310Ala of GRIK3 gene is not associated with alcohol dependence or any of its subgroups.
Title: Family-based and case-control study of glutamate receptor GRIK3 Ser310Ala polymorphism in alcohol dependence.
Our results suggest that the analysed polymorphisms ofANKK1 and ADH4 can play an important part in the pathogenesis of alcohol abuse
Title: [Research on associations between selected polymorphisms of genes DRD2, 5HTT, GRIK3, ADH4 and alcohol dependence syndrome].
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Glutamatergic gene variants impact the clinical profile of efficacy and side effects of haloperidol.
Some support (at a nominal significance level of 0.05/0.01) was found for association between GRIK3 and depression.
Title: Association of existing and new candidate genes for anxiety, depression and personality traits in older people.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A comprehensive family-based replication study of schizophrenia genes. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH79120 (e-PCR)
- UniSTS:19725

SHGC-31550 (e-PCR)
- UniSTS:44559

SHGC-143130 (e-PCR)
- UniSTS:171804

AL009961 (e-PCR)
- UniSTS:44063

GRIK3_966 (e-PCR)
- UniSTS:277295

GRIK3_V247 (e-PCR)
- UniSTS:277295

D11S4066 (e-PCR)
- UniSTS:154171

AL010015 (e-PCR)
- UniSTS:30018

G59361 (e-PCR)
- UniSTS:136526

D1S472 (e-PCR), detects polymorphism
- UniSTS:59006

AL034266 (e-PCR)
- UniSTS:94086

D1S1444 (e-PCR)
- UniSTS:149640

G15720 (e-PCR)
- UniSTS:80029

D1S472 (e-PCR), detects polymorphism
- UniSTS:53152

SHGC-112050 (e-PCR)
- UniSTS:181926

RH103118 (e-PCR)
- UniSTS:97452

SHGC-74612 (e-PCR)
- UniSTS:5875

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate receptor activity	TAS Traceable Author Statement more info	PubMed
enables glutamate-gated calcium ion channel activity	IEA Inferred from Electronic Annotation more info
enables glutamate-gated receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate-gated receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables kainate selective glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables kainate selective glutamate receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled glutamate receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in glutamate receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in ionotropic glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of synaptic transmission, glutamatergic	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of membrane potential	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of membrane potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
part_of kainate selective glutamate receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in perikaryon	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in terminal bouton	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: glutamate receptor ionotropic, kainate 3

Names: dJ1090M5.1 (glutamate receptor, ionotropic, kainate 3 (GLUR7)); excitatory amino acid receptor 5; gluR-7; glutamate receptor 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_011447.1 RefSeqGene

Range

4729..243717

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000831.4 → NP_000822.2 glutamate receptor ionotropic, kainate 3 precursor

See identical proteins and their annotated locations for NP_000822.2

Status: REVIEWED

Source sequence(s)

AC117945, AJ249210, AL355386, AW898512, BG057125, BG818719, BQ446793, DR003075, DT217951, U16127

Consensus CDS

CCDS416.1

UniProtKB/Swiss-Prot

A9Z1Z8, B1AMS6, Q13003, Q13004, Q16136

UniProtKB/TrEMBL

Q96QG5

Related

ENSP00000362183.3, ENST00000373091.8

Conserved Domains (4) summary

cd06393
Location:34 → 417

PBP1_iGluR_Kainate_GluR5_7; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR5-7 subunits of Kainate receptor

cd13723
Location:433 → 801

PBP2_iGluR_Kainate_GluR7; GluR7 subtype of kainate receptor, type 2 periplasmic-binding fold superfamily

pfam00060
Location:564 → 832

Lig_chan; Ligand-gated ion channel

pfam01094
Location:55 → 398

ANF_receptor; Receptor family ligand binding region