U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    AMIGO1 adhesion molecule with Ig like domain 1 [ Homo sapiens (human) ]

    Gene ID: 57463, updated on 10-Dec-2024

    Summary

    Official Symbol
    AMIGO1provided by HGNC
    Official Full Name
    adhesion molecule with Ig like domain 1provided by HGNC
    Primary source
    HGNC:HGNC:20824
    See related
    Ensembl:ENSG00000181754 MIM:615689; AllianceGenome:HGNC:20824
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ALI2; AMIGO; AMIGO-1
    Summary
    Predicted to enable potassium channel regulator activity. Predicted to be involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; and nervous system development. Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be located in dendrite; neuronal cell body membrane; and voltage-gated potassium channel complex. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in brain (RPKM 9.3), adrenal (RPKM 6.7) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See AMIGO1 in Genome Data Viewer
    Location:
    1p13.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (109504178..109509727, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (109536945..109542494, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (110046800..110052349, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:110025999-110026616 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:110026617-110027236 Neighboring gene ataxin 7 like 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1151 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1152 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1441 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:110036856-110037356 Neighboring gene cytochrome b561 family member D1 Neighboring gene Sharpr-MPRA regulatory region 8825 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:110042111-110042610 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1153 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1154 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1155 Neighboring gene uncharacterized LOC105378893 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1442 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1443 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:110073289-110073457 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:110082007-110082508 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:110082509-110083008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:110086313-110086851 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:110089013-110089249 Neighboring gene G protein-coupled receptor 61

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (29 hits/1258 screens)

    EBI GWAS Catalog

    Description
    New loci associated with kidney function and chronic kidney disease.
    EBI GWAS Catalog

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables potassium channel regulator activity  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in axonal fasciculation PubMed 
    involved_in axonogenesis  
    involved_in brain development  
    involved_in cellular response to L-glutamate  
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules PubMed 
    involved_in myelination PubMed 
    involved_in positive regulation of axonogenesis PubMed 
    involved_in positive regulation of neuron projection development  
    involved_in positive regulation of potassium ion transmembrane transport  
    involved_in positive regulation of synapse assembly  
    Component Evidence Code Pubs
    located_in dendrite  
    is_active_in membrane  
    located_in neuronal cell body membrane  
    located_in pericellular basket  
    located_in perikaryon  
    part_of voltage-gated potassium channel complex  

    General protein information

    Preferred Names
    amphoterin-induced protein 1
    Names
    alivin-2
    amphoterin-induced gene and ORF

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020703.4NP_065754.2  amphoterin-induced protein 1 precursor

      See identical proteins and their annotated locations for NP_065754.2

      Status: VALIDATED

      Source sequence(s)
      AK295678, AL355145, HY122839
      Consensus CDS
      CCDS30795.1
      UniProtKB/Swiss-Prot
      B4DIM3, Q86WK6, Q8IW71, Q9ULQ7
      Related
      ENSP00000358880.4, ENST00000369864.5
      Conserved Domains (3) summary
      smart00409
      Location:279358
      IG; Immunoglobulin
      COG4886
      Location:66242
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:6687
      LRR_RI; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      109504178..109509727 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011541812.3XP_011540114.1  amphoterin-induced protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011540114.1

      UniProtKB/Swiss-Prot
      B4DIM3, Q86WK6, Q8IW71, Q9ULQ7
      Related
      ENSP00000358878.1, ENST00000369862.1
      Conserved Domains (3) summary
      smart00409
      Location:279358
      IG; Immunoglobulin
      COG4886
      Location:66242
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:6687
      LRR_RI; leucine-rich repeat [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      109536945..109542494 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337816.1XP_054193791.1  amphoterin-induced protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B4DIM3, Q86WK6, Q8IW71, Q9ULQ7
    External link. Please review our privacy policy.